Weak affinity scFvs directed towards carbohydrate structures Lewis x and sialyl-Lewis x
The Lewis (Le) blood group antigens are a set of fucosylated glycan structures. They are present as N- and O-linked structures on glycoproteins and as glycolipid-based structures on cell surfaces. Depending on the exact structure, the Lewis group is divided into four subgroups; Lea, Leb, Lex and Ley. Lex and Lea can further be sialylated and/or sulfonated. Among these, Lex has been found to be imp