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Polypharmacy increases the risk of drug-drug interactions that may disturb treatment effects. The aim of this study was to investigate the frequency of codispensing of potentially interacting or contraindicated drugs related to PH-specific treatment in the Swedish pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) population. All prescribed drugs, on an

Ambulance nurses in prehospital emergency care must assess, treat, and triage patients with mental health issues. This study aimed to investigate the self-perceived competence of ambulance nurses in prehospital emergency care of patients with mental illness. A cross-sectional questionnaire survey was done, a question-index value (Q-IV; range: 0-1.0) was defined as a summary of the proportion of po

PurposeMagnetization transfer saturation (MTsat) is a useful marker to probe tissue macromolecular content and myelination in the brain. The increased B1+ inhomogeneity at 7T and significantly larger saturation pulse flip angles which are often used for postmortem studies exceed the limits where previous B1+correction methods are applicable. Here, we develop a calibration-based correction model an

Purpose: To study the risk of incident breast cancer and subtype-specific breast cancer in relation to excess body weight in a contemporary Swedish prospective cohort study, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. Methods: A total of 35,412 postmenopausal women attending mammography and included in the KARMA study provided baseline data on body mass index (B

Cellulär kommunikation utvecklas ständigt; för närvarande installeras 5G-system och forskning kring 6G pågår. Tre användningsfall som diskuteras är enhanced mobile broadband (eMBB), massive machine-type communication (mMTC) och ultra-reliable low-latency communication (URLLC). För att uppfylla kraven i dessa användningsfall behövs ny teknik och en kandidat är massive multiple-input multiple-outputCellular communication is constantly evolving; currently 5G systems are being deployed and research towards 6G is ongoing. Three use cases have been discussed as enhanced mobile broadband (eMBB), massive machine-type communication (mMTC), and ultra-reliable low-latency communication (URLLC). To fulfill the requirements of these use cases, new technologies are needed and one enabler is massive mult

During the last 10 years, the mobile phone and the emergence of websites, such as Youtube, which facilitate user-generated content, have enabled an explosion of pictures and video clips posted on the internet by civilians documenting the activities of authority figures. This “sousveillance” is a kind of inverse surveillance, reciprocal to surveillance, where members of the grassroots monitor those

PURPOSE: To evaluate vertical acceleration, vector magnitude, non-wear time, valid day classifications and valid period classifications, in the data processing phase when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy (CP).MATERIAL AND METHODS: Accelerometer data retrieved from 33 non-ambulant children and adolescents (4-17 years) with CP, were

A promising strategy to enable patient stratification for targeted therapies is to monitor the target expression in a tumor by radionuclide molecular imaging. Affibody molecules (7 kDa) are nonimmunoglobulin scaffold proteins with a 25-fold smaller size than intact antibodies. They have shown an apparent potential as molecular imaging probes both in preclinical and clinical studies. Earlier, we fo

Affibody molecules are small scaffold-based affinity proteins with promising properties as probes for radionuclide-based molecular imaging. However, a high reabsorption of radiolabeled Affibody molecules in kidneys is an issue. We have shown that the use of (125)I-3-iodo-((4-hydroxyphenyl)ethyl)maleimide (IHPEM) for site-specific labeling of cysteine-containing Affibody molecules provides high tum

BACKGROUND: Lateral ankle sprain (LAS) is a common and burdensome injury. However, the quality of its management is scant. Nowadays, physiotherapy management of musculoskeletal diseases seems to be generally not based on research evidence. Studies that investigated the knowledge-to-practice gap in LAS management are yet to be carried out. Therefore, this research investigated physiotherapists' kno

This paper provides a comprehensive literature review of preliminary publications on green and sustainable public procurement from the year 2000 until now. The aim of the review is to organise, evaluate and identify patterns and clusters in published articles, providing an overview of the state of the art in green and sustainable public procurement. Classification of the data identified three over

Transitioning from linear to circular production systems requires interactions that include cross-sectoral collaboration in networks. Understanding the role of collaboration within these networks can support the transition to a circular economy. To understand cross-sectoral collaborative endeavors, this paper develops a collaboration framework for circular economy by combining and interlinking thr

Through ultrarelativistic particle collisions at the LHC, it is possible to deconfine quarks and gluons. This deconfinement gives rise to a strongly interacting medium, referred to as the Quark-Gluon Plasma (QGP). One of the earliest proposed and observed signatures of the QGP was the enhanced production of strange hadrons since the medium can thermally produce strange quarks. However, recent stud

Research shows that much of the blame for waste and lost resources can be traced to the design phase. The implementation of Circular Economy (CE) has the potential to reduce waste by encouraging reuse of resources in a closed loop. Given that designers are involved in the design process, this paper investigates whether they are properly equipped to take responsibility for the shift toward CE. A gr

The thesis aims to develop a 3D digital approach to the stylistic and typo-technological study of coroplastic, focusing on small figurines. The case study to test the method is a sample of terracotta statuettes from an assemblage of approximately 2000 statues and figurines found at the beginning of the 20th century in a rural open-air sanctuary at Ayia Irini (Cyprus) by the archaeologists of the S