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The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive
Children in Angola are affected by a high burden of disease caused by pneumococcal infections. The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the childhood immunization programme in 2013 but the serotype distribution of Streptococcus pneumoniae and antimicrobial susceptibility patterns are unknown. We did a cross-sectional nasopharyngeal carriage study in Luanda and Saurimo
Initiation of celiac disease is triggered in the gastrointestinal tract by transglutaminase 2 (TG2) assisted deamidation of gluten peptides. Deamidation is a side-reaction to transamidation and occurs if primary amines are absent. In contrast to deamidation, transamidation does not trigger an immune response. The aim of the study was to identify a suitable food additive that interacts with TG2 bin
The enzyme transglutaminase 2 (TG2) plays a crucial role in the initiation of celiac disease by catalyzing the deamidation of gluten peptides. In susceptible individuals, the deamidated peptides initiate an immune response leading to celiac disease. Several studies have addressed lactic fermentation plus addition of enzymes as a means to degrade gluten in order to prevent adverse response in celia
The paper analyses the role of ideas, past experience and crises in the process leading to theoretical and political disputes and the changes of monetary and banking policy in Sweden in 1844/45. It also analyses the role of institutional settings and types of actors involved in the decision-making process. A comparative approach is deployed. Policy changes at the time in the poor and peripheral Sw
Recent "peace" deals between Israel and Gulf Arab states herald not a more just and harmonious region, but a more militarized, securitized, and repressive one
Beginning in December 2010, the Arab world was hit by huge anti-government revolutionary waves, popularly known as the Arab Spring. In Syria, the uprising did not take long to morph into a bloody war with international and regional powers wrestling for geopolitical influence and economic gain. The war has significantly changed Syria in terms of politics, economy, and culture. While the first two h
The aim of this paper is to investigate the uses of schm-reduplications, also known as deprecative reduplications, in current corona virus related discourse. The investigation shows that schm-reduplications, such as covid schmovid, corona schmorona and pandemic schmandemic, are often used in a spirit-lifting function, to show that, despite all the threats and complications posed by the virus and n
Att vatten övergår till ånga när man hettar upp det är ett välkänt fenomen, men även materia som bygger upp atomkärnor kommer att genomgå en fasövergång om den hettas upp tillräckligt mycket. Det som då bildas är ett kvark-gluonplasma (QGP), en exotisk form av materia där atomkärnans minsta beståndsdelar - kvarkar och gluoner - mer eller mindre rör sig fritt, vilket radikalt skiljer sig från vanliBy colliding heavy nuclei at high energies, which is done at RHIC and the LHC, a strongly interacting Quark Gluon Plasma (QGP) is created. This manifests itself through several different signatures, which until recently was thought to uniquely probe the QGP. Recently, however, similar signatures have been observed also in small systems, such as pp collisions with high charged-particle multiplicity
Due to the complexity of clinical breast cancer imaging systems, their validation and optimization are challenging tasks, which require both preclinical and clinical studies. This is particularly true for systems used in breast cancer screening due to the low prevalence of disease in a screening population. Validation for screening requires clinical trials involving very large numbers of volunteer
Finite fermion systems are known to exhibit shell structure in the weakly interacting regime, as is well known from atoms, nuclei, metallic clusters, or even quantum dots in two dimensions. All these systems have in common that the particle interactions between electrons or nucleons are spatially isotropic. Dipolar quantum systems as they have been realized with ultracold gases, however, are gover
Although the potential advantages of clinical germline genome editing (GGE) over currently available methods are limited, the implementation of GGE in the clinic has been proposed and discussed. Ethical issues related to such an application have been extensively debated, meanwhile, seemingly less attention has been paid to ethical implications of studies which would have to be conducted in order t
Whole-exome and whole-genome sequencing (WES, WGS) can generate an unprecedented amount of complex information, making the informed consent (IC) process challenging. The aim of our study was to assess the readability of English IC forms for clinical whole-exome and whole-genome sequencing using the SMOG and Flesch-Kincaid formulas. We analysed 36 forms, most of which were from US providers. The me
A variety of health-related genetic testing is currently advertized directly to consumers. This article provides a timely overview of direct-to-consumer genetic testing (DTC GT) and salient ethical issues, as well as an analysis of the impact of the recently adopted regulation on in vitro diagnostic medical devices on DTC GT. DTC GT companies currently employ new testing approaches, report on a wi
Whole exome sequencing (WES) and whole genome sequencing (WGS) have become increasingly available in the research and clinical settings and are now also being offered by direct-to-consumer (DTC) genetic testing (GT) companies. This offer can be perceived as amplifying the already identified concerns regarding adequacy of informed consent (IC) for both WES/WGS and the DTC GT context. We performed a
This paper reports findings from Germany-based participants in the "Your DNA, Your Say" study, a collaborative effort among researchers in more than 20 countries across the world to explore public attitudes, values and opinions towards willingness to donate genomic and other personal data for use by others. Based on a representative sample of German residents (n = 1506) who completed the German-la
Nonsense-mediated mRNA decay (NMD) is a eukaryotic quality control system that recognizes and degrades transcripts containing NMD cis elements in their 3'untranslated region (UTR). In yeasts, unusually long 3'UTRs act as NMD cis elements, whereas in vertebrates, NMD is induced by introns located >50 nt downstream from the stop codon. In vertebrates, splicing leads to deposition of exon junction co
