Objectives: Cholinergic dysfunction plays a prominent role in cognitive impairment in Parkinson's disease (PD). The aim of this study was to assess the relationship of baseline and longitudinal basal forebrain atrophy with cognitive decline and dementia in PD. Methods: We included 106 non-demented PD patients, 19 PD dementia (PDD) patients and 42 controls with longitudinal structural MRI and cogni

Ocean Drilling Program (ODP) Site 1051 (Blake Nose, western North Atlantic) is of crucial importance for reconstructing diatom evolution and biosiliceous sedimentation patterns through the early Cenozoic period of extreme greenhouse warmth followed by the progressive global cooling. The magnetostratigraphy in Hole 1051A, however, has been subject to divergent interpretations resulting in multi-mil

In this paper, an investigation is done into the potential of increasing the coolant temperature of an engine to maximize the powertrain efficiency. The study takes a holistic approach by trying to optimise the combined engine and waste heat recovery system. The work was done experimentally on a Volvo 4-cylinder light duty diesel engine in combination with Rankine cycle simulations. For the study,

In this study, the effects of fin configurations and layouts on thermal and hydraulic performances of printed circuit heat exchangers (PCHEs) with supercritical liquefied natural gas as the working fluid are studied by a numerical method, and the overall heat transfer performance of various parameters is evaluated by the JF factor. Firstly, the effect of four different airfoil configurations, i.e.

Aims The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overwe

The overall aims of this thesis were to improve prediction, diagnostics and knowledge on epidemiology of sepsis. In paper I, we developed and evaluated an integrated platform for rapid analysis of sepsis-causing organisms directly from blood samples. Testing with blood samples spiked with bacteria and samples from septic patients indicate that the detection limit of the system is in the upper partThe overall aims of this thesis were to improve prediction, diagnostics and knowledge on epidemiology of sepsis. In paper I, we developed and evaluated an integrated platform for rapid analysis of sepsis-causing organisms directly from blood samples. Testing with blood samples spiked with bacteria and samples from septic patients indicate that the detection limit of the system is in the upper part

Efficient protection of huge amount of IoT produced data is key for wide scale data analytic services. The most efficient way is to use pure symmetric encryption as that allows both fast decryption at the analytic engine side as well as energy efficient encryption at the IoT side. However, symmetric encryption can only be performed if there is a way to directly map an encrypted object to the corre

Energy flow is a central characteristic in all ecosystems, and it has attracted considerable scientific attention due to its significant effects on the stability of food webs. Lake ecosystems that undergo regime shifts (clear water phase, phytoplankton dominated changed into turbid water, macrophytes dominated or vice versa) are characterized by a series of transformation in trophic structure. Alt

In this climate change and biodiversity loss focus, Harriet Bulkeley, Professor at Durham University in the UK and Kes McCormick, Associate Professor at Lund University in Sweden, argue that nature-based solutions in the city are not just for the birds.

The Governance of Urban Sustainability Transitions project was established to examine, inform and advance the governance of sustainability transitions through urban living labs. The findings could help address many of the economic, social and environmental concerns of the 21st century.

Sharing Cities Sweden aims to put Sweden on the map as a country that actively and critically works with the sharing economy in cities. We are developing world-leading test-beds for the sharing economy in Stockholm, Gothenburg, Malmö and Umeå. We are developing a national node to significantly improve national and international cooperation and promote an exchange of experience on sharing cities.

Objectives: Current guidelines rank abatacept, rituximab, tocilizumab and TNF-inhibitors (TNFi) as having equal effectiveness for the treatment of RA, at least as second line therapies. These recommendations are mainly based on meta-analysis of randomized controlled trials, with few direct drug-drug comparisons. Our objective was to compare the real-world absolute and relative effectiveness among

The adsorption of proteins is a very common phenomenon, happening almost always when a protein solution comes into contact with a solid. However, it is far from always clear what the results of adsorption will be in terms of adsorbed amount, protein orientation, and protein conformation. In this work, the adsorption of two proteins – histatin 5 and fibrinogen – has been studied using coarse-graineThe adsorption of proteins is a very common phenomenon, happening almost always when a protein solution comes into contact with a solid. However, it is far from always clear what the results of adsorption will be in terms of adsorbed amount, protein orientation, and protein conformation. In this work, the adsorption of two proteins – histatin 5 and fibrinogen – has been studied using coarse-graine

Komplexiteten hos a-synukleinopatier, som inkluderar multipel systematrofi (MSA) och Parkinsons sjukdom (PS), är inte helt klarlagd. Det är känt att patologisk ansamling av a-synuclein (a-syn) till fiberlika proteinaggregat är ett cellulärt kännetecken för dessa sjukdomar. a-Syn-positiva aggregat förekommer i nervceller i PS och Lewy body demens (LBD) och i oligodendrocyter i MSA. Mycket forskningThe complexity of a-synucleinopathies, which include multiple system atrophy (MSA) and Parkinson’s disease (PD), is not entirely understood. It is known that pathological accumulation of a-synuclein (a-syn) into proteinaceous aggregates is a cellular hallmark of these diseases. a-Syn positive aggregates appear in neurons in PD and dementia with Lewy bodies (DLB), and in oligodendrocytes in MSA. Mu

This white paper contains six policy ideas that may help countries in coping with theCOVID-19 pandemic. The paper focuses on policies that can slow down the spread of the disease, better protect high-risk groups and leverage that a large part of the labor force is idle. For each policy idea, we describe the problem it is meant to solve, what may be leveraged to solve it, and a brief analysis of beThis white paper contains six policy ideas that may help countries in coping with theCOVID-19 pandemic. The paper focuses on policies that can slow down the spread of the disease, better protect high-risk groups and leverage that a large part of the labor force is idle. For each policy idea, we describe the problem it is meant to solve, what may be leveraged to solve it, and a brief analysis of be

The stacked multi-level (SML) klystron modulator topology has been suggested as an alternative to conventional pulse transformer based topologies in an attempt to improve output pulse performance and reduce system size for long pulse applications. In this topology, a power converter chain including a high frequency transformer generates the output pulse in a pulse modulation/demodulation scheme, e

We demonstrate a novel and rapid method for nanowire (NW) solar cell processing. NW arrays were embedded in photoresist. The strong absorption of light in the NWs leads to self-limited exposure of the resist, which enables selective removal of the exposed part of the resist, opening up for the tips of the NWs and further processing. The UV-exposure technology allows a fast and low-cost process com