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BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 bioma

Out-of-pocket (OOP) expenditures for childbirth in Bangladesh have increased substantially, intensifying financial pressure on lower-income households. While wealthier groups historically bore higher delivery costs, recent trends indicate a narrowing gap in spending across socioeconomic strata. This study investigates the drivers of this convergence in delivery-related expenditures between 2014 an

BackgroundWomen’s empowerment may influence non-communicable disease (NCD) risk. However, evidence on these associations among women in Bangladesh remains limited. This study examined the associations between women’s empowerment and the prevalence of selected non-communicable conditions among ever-married reproductive-aged women in Bangladesh.MethodsData from the 2022 Bangladesh Demographic and He

Motivation Machine learning offers a powerful approach for building predictive models from high-dimensional molecular data. Omics technologies such as transcriptomics, proteomics, and metabolomics quantify thousands of molecules simultaneously, providing deep insights into disease biology. Integrating multiple modalities can enhance predictive performance, as shown in histology-omics and holter-om

Introduction: Using time-limited trials of low-dose, sustained-release morphine to reduce chronic breathlessness to evaluate net effects may generate opioid withdrawal symptoms if medication is ceased. This sub-study of a larger randomized, placebo-controlled, double-blind trial aimed to evaluate if this occurred. Methods: People with modified Medical Research Council breathlessness scores of 3 or

Antipsychotics are mainly used for severe psychiatric disorders. Risperidone is the only antipsychotic approved for younger children. Aripiprazole is approved for older children, ziprasidone and lurasidone for adolescents. To describe paediatric utilisation of antipsychotic drugs in Sweden. Dispensations of antipsychotic drugs to children aged 5–17 years from 2008 to 2021 were analysed using the N

Taylor Swift is one of today’s most beloved songwriters, however, all aspects of her work are not recognised. Swift frequently references queerness, yet this is often overlooked. Previous scholarship focused on Swift and queerness has either centred around Swift’s support for LGBTQ+ causes or the subgroup of Swift’s fans who acknowledges and embraces her expressed queerness, but textual analysis o

Att bygga en proteinmodell, strukturbestämning av ett förmodat urokanatreduktas Kardiometabola sjukdomar som hjärtsvikt och typ 2 diabetes blir allt vanligare. Studier har lyckats hitta en länk mellan den mänskliga bakteriefloran och utvecklingen av sådana sjukdomar. En metabolit, imidazolpropionat (ImP), produceras av bakterier och kan tas upp samt transporteras via blodet. Väl i blodet kan den

In 2015, the United Nations General Assembly unanimously adopted the 2030 Agenda for Sustainable Development with 17 Sustainable Development Goals and 169 targets. This agreement sets a 15-year plan to steer the world towards a more sustainable and equitable trajectory. However, as we have passed halfway through this agenda, the world is far from achieving most goals within this timeframe. Such la

Objective: Psychosocial stress increases the risk for subsequent episodes of alcohol use disorder (AUD) and drug use disorder (DUD), with most studies assessing stress exposure by questionnaire or interview methods. We developed an environmental risk score (ERS) using multiple classes of stressful life events (SLEs) obtained from national Swedish registries. Method: We assessed, in the entire adul

In a recent paper, Fack et al. (2019, American Economic Review) convincingly argue and theoretically demonstrate that there may be strong incentives for students to play non-truth-telling strategies when reporting preferences over schools, even when the celebrated deferred acceptance algorithm is employed. Their statistical test also rejects the (weak) truth-telling assumption in favour of another

Strut-based structures, such as lattices, produced using additive manufacturing (AM) offer significant potential for applications requiring lightweighting and structural compliance. However, conventional Design for AM (DfAM) approaches often assume idealised material behaviour, which can be misleading for thin strut-based structures where geometric parameters and process-induced effects significan

Decoupling key intermediates’ adsorption via asymmetric 3d-5d-orbital hybridization overcomes the intrinsic scaling relation bottleneck, enabling rational design of high-performance, durable multifunctional electrocatalysts for anion exchange membrane water electrolyzers (AEMWEs) and Zn–air batteries (ZABs). Here, we reveal that asymmetric 3d-5d-orbital hybridization, engineered through the synerg

Energy security crises have historically been turning points for energy systems, exposing vulnerabilities, reshaping policy priorities, and boosting technological change. However, whether—and to what extent—such crises accelerate low-carbon transitions remains contested. This paper examines the effects of the 2022 energy crisis on the European Union (EU)’s energy transition, using policy analysis

Archaeology’s turn to digital documentation poses questions for the long-term preservation of archaeological data and their future re-use—questions that have relevance also for the debates about open science and data archivization in the natural and social sciences. In this paper, I investigate how the nexus of epistemology and digital materialities affect attempts to open up archaeological data f