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Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for hematologic and immunologic diseases. However, graft-versus-host disease (GVHD) may develop when donor-derived T cells recognize and damage genetically distinct normal host tissues. In addition to TCR signaling, costimulatory pathways are involved in T cell activation. CD27 is a TNFR family member expr

Mammals have extremely limited regenerative capabilities; however, axolotls are profoundly regenerative and can replace entire limbs. The mechanisms underlying limb regeneration remain poorly understood, partly because the enormous and incompletely sequenced genomes of axolotls have hindered the study of genes facilitating regeneration. We assembled and annotated a de novo transcriptome using RNA-

Granzyme B (GzmB) is a key cytotoxic molecule utilized by T cells to kill pathogen-infected cells or transformed tumor cells. Previous studies using allogeneic hematopoietic cell transplantation (allo-HCT) murine models showed that GzmB is required for CD8+ T cells to cause graft-versus-host disease (GVHD). However, our recent study demonstrated that GzmB-mediated damage of CD8+ T cells diminished

The BGOOD experiment at the ELSA facility in Bonn has been commissioned within the framework of an international collaboration. The experiment pursues a systematic investigation of non-strange and strange meson photoproduction, in particular t-channel processes at low momentum transfer. The setup uniquely combines a central almost 4 π acceptance BGO crystal calorimeter with a large aperture forwar

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology.METHODS: We conducted a nested case-control study within the Syncope S

Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We hypothesized that a temporal multiphasic process of extracellular matrix (ECM) degradation and formation underlie this effect. We aimed to characterize the temporal ECM remodeling of human knee OA articular cartilage in response to sprifermin treatme

Birds, and especially raptors, are believed to forage mainly using visual cues. Indeed, raptors (scavengers and predators) have the highest visual acuity known to date. However, scavengers and predators differ in their visual systems such as in their foveal configuration. While the function of the foveal shape remains unknown, individual variation has never been quantified in birds. In this study,

Grout based on microfine cement is mainly used for sealing of rock fractures in underground construction with high sealing requirements. This grout is known as hard dispersed, compared to grouts based on ordinary Portland cement. This study investigates the possibility of using ultrasound to improve the dispersion of microfine cement grout. Ultrasound dispersion is compared with dispersion efficie

Gel formation by surfactant molecules is generally controlled by thermodynamics rather than kinetics. Mixtures of long-chain alcohols and surfactants are widely used in various cosmetic and pharmaceutical products. The cooling rate used to produce the products is known to be a key parameter to control the rheological properties and the final texture. However, the physical-chemistry links between t

In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged t

Plant-based beverages are increasing in popularity and quinoa is an attractive option. A hygienic implication linked to the production of beverages from raw material originating from plants is the high microbial contamination. The safety of the product can be guaranteed by lactic acid fermentation, and by using a probiotic strain as starter culture for the fermentation, the final product will bene

In order to gain insights into the biogeographic processes underlying biotic diversification in the Atlantic Forest (AF), we used a multi-locus approach to examine the evolutionary history of the White-shouldered Fire-eye (Pyriglena leucoptera) and the Fringe-backed Fire-eye (Pyriglena atra), two parapatric sister species endemic to the AF. We sequenced one mitochondrial, three Z chromosome-linked

A unique exposure of a strongly deformed late Mesoproterozoic augen-granite (U–Pb zircon age 1146 ± 4 Ma) was detected within rocks on the eastern rim of the West African Craton. These rocks, together with their sedimentary cover, were reworked during the Neoproterozoic Pan-African Dahomeyan orogeny, and are now incorporated in the Dahomeyan orogenic belt of southeast Ghana. To the authors’ knowle

The present work details a study of the 3D-modeling of dual-fuel engines, with a specific focus on medium speed marine engines. These operate under the fumigated approach, which means that the second fuel, which replaces most of the diesel fuel, is added in the intake duct. This type of engine requires the least amount of modifications to the current medium speed diesel engine and is therefore an

Cutaneous malignant melanoma (CMM) is one of the most aggressive skin malignancies with poor prognosisfor the patients with metastatic disease. Earlier studies have highlighted the existing molecular diversityamongst CMM tumors. Such diversity does not result from the malignant cells alone but a product of multitudeof complex interactions among the melanoma and non-melanoma cells in the tumor micr

Autoimmune limbic encephalitis is part of CASPR 2 antibody-associated disease. A man with this rare disorder and a very high antibody titre had a unique history of laboratory exposure to the antigen. Together with earlier observations this case calls for caution in laboratory handling of nerve tissue.

Viable city logistics are built on a sound business model that considers the financial viability and performance, and the role of externalities and stakeholders. To this end, the purpose of this dissertation is to increase understanding of how a business model can contribute to achieving viable city logistics initiatives.The research presented is qualitative and consists of three studies and five