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An organism's life history is closely interlinked with its allocation of energy between growth and reproduction at different life stages. Theoretical models have established that diminishing returns from reproductive investment promote strategies with simultaneous investment into growth and reproduction (indeterminate growth) over strategies with distinct phases of growth and reproduction (determi
Background Improved availability of mobile phones in low- and middle-income countries (LMICs) offer an opportunity to improve delivery of Community Case Management (CCM). Despite enthusiasm for introducing mHealth into healthcare across LMICs, end-user attitudes towards mHealth solutions for CCM are limited. We aimed to explore Health Surveillance Assistants’ (HSAs) perceptions of the Supporting L
A long run of PVCs “sandwiched” in between the sinus beats resulting in an almost doubling of the heart rate—interpolated PVCs in bigeminy—is described. This case illustrates three interesting aspects of interpolated PVCs. Although they are not uncommon, long runs of interpolated PVCs in bigeminy are rare findings. In this case, the arrhythmia had a duration of 3 minutes. Second, it illustrates th
Objectives: The present study evaluates the effect of food intake on 90 biomarkers for cardiovascular disease (CVD) and inflammation with the Proseek Multiplex CVD II kit. Methods: Twenty-two healthy subjects (11 male and 11 females aged 25.9 ± 4.2 years) were investigated. A total of 90 biomarkers were measured before a standardized meal, 30 and 120 minutes thereafter with the Proseek Multiplex C
Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic secretion results from vastly different release probabilities of individual insulin granules, but the morphological and molecular basis for this is unclear. Here, we show that human insulin secretion and exocytosis critical
An invariant differential cross section measurement of inclusive π0 and η meson production at mid-rapidity in pp collisions at s=8 TeV was carried out by the ALICE experiment at the LHC. The spectra of π0 and η mesons were measured in transverse momentum ranges of 0.3
ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progenito
We present two new data structures for computing values of an n-variate polynomial P of degree at most d over a finite field of q elements. Assuming that d divides q-1, our first data structure relies on (d+1)n+2 tabulated values of P to produce the value of P at any of the qn points using O(nqd2) arithmetic operations in the finite field. Assuming that s divides d and d/s divides q-1, our second
Parkinson's disease (PD) is a neurodegenerative disorder characterized by typical motor features that result from dopamine (DA) depletion in the striatum. DA replacement therapy with L-DOPA is the most efficacious symptomatic treatment, but causes complications that limit its utility, in particular, L-DOPA-induced dyskinesia (LID). LID is primarily caused by pre-synaptic and post-synaptic changes
Swedish asthma guidelines recommend treating asthma with the lowest effective dose possible. These recommendations are both hard to follow and seldom considered enough in asthma care today. As an example, combination therapy with inhaled corticosteroids (ICS) and long acting beta agonists (LABA) should only be considered if asthma control is not achieved with low to medium dose ICS daily. However,
Background and aims: IL-27 is an immunoregulatory cytokine belonging to the IL-6/IL-12 family that was found to be elevated in acute coronary syndrome (ACS) patients. We investigated whether IL-27 is related to post-ischemic cardiac remodeling and long-term prognosis in this patient group. Methods: We included 524 ACS patients, defined as acute myocardial infarction (AMI) or unstable angina (UA).
The formalisation of customary land rights in Africa, as an alternative to their privatisation, is gaining increasing attention from scholars and policy makers. In this article, we use findings from Petauke district in eastern Zambia to discuss the impact of such reforms, where so-called traditional landholding certificates were implemented by the Petauke District Land Alliance in 2010. Based on i
The 1807 ban on the importation of slaves is said to have had severe consequences for farmers in South Africa’s Southwestern Cape, an areaof wheat and wine farming that used large numbers of slave labourers.The ban resulted in a rapid rise in slave prices, which signif icantly increased input costs. In contrast, the effect of the ban was apparently much more moderate in the eastern parts of the co
This article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the Camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, ScouThis article examines reports of physical punishment at the national Swedish Boy Scout camp Åvatyr in 1950. The Swedish newspapers Dagens Nyheter and Expressen described the events in terms of bullying and violence, while the camp directors declared that the reports were merely exaggerated accounts of innocent pranks and practical jokes. This article draws information from newspaper articles, Scou
In this thesis diet and health of people who lived in southern Sweden 2300-1100 BCE is studied. The study is based on bioarchaeological analyses of human remains from 46 localities in the areas of Uppland, Närke, Östergötland, Västergötland, and Scania. The studies are based on skeletal remains from a minimum number of 310 individuals that have been analysed both osteologically and biochemically.
The accumulation of biofilms in porous media is likely to influence the overall hydraulic properties and, consequently, a sound understanding of the process is required for the proper design and management of many technological applications. In order to bring some light into this phenomenon we present a mechanistic model to study the variably saturated hydraulic properties of bio-amended soils. Sp
