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John Maynard Keynes brukar betraktas som världens mest berömde nationalekonom under mellankrigstiden och kanske hela 1900-talet. I början av 1920-talet lyste emellertid ett annat namn minst lika kraftigt på ekonomernas stjärnhimmel – Gustav Cassel. I denna artikel används omnämnanden av de båda ekonomerna i tidskriften The Economist som måttstock för att bedöma vem av de båda som var mest berömd p
Sverige hade sedan länge varit en pålitlig medlem av Internationella valutafonden när den tillträdande socialdemokratiska regeringen 1982 slog till med en 16-procentig devalvering som utlöste febril aktivitet i förhållandet mellan Sverige och fonden. IMF genomförde en särskilt konsultation och devalveringen diskuterades tre gånger i fondens direktion. Såväl Sverige som IMF lyckades emellertid vänd
Desoxyribosenucleic acid, DNA, and cellulose molecules self-assemble in aqueous systems. This aggregation is the basis of the important functions of these biological macromolecules. Both DNA and cellulose have significant polar and nonpolar parts and there is a delicate balance between hydrophilic and hydrophobic interactions. The hydrophilic interactions related to net charges have been thoroughl
The mast cell granule metalloprotease CPA3 is proposed to have important tissue homeostatic functions. However, the basal CPA3 mRNA and protein expression among mast cell populations has remained poorly investigated. Using a novel histology-based methodology that yields quantitative data on mRNA and protein expression at a single-cell level, the present study maps CPA3 mRNA and protein throughout
Recension av avhandlingDissertation review
This paper explores the mental-models of Swedish planners in order to understand the extent to which they support the ideals of sustainable transport. Focussing on three critical challenges: forecast-led versus vision-led planning; tackling congestion; and, public acceptability; the findings, drawn from in-depth interviews, demonstrate mostly advanced thinking. However, implementation can be at od
Human papillomavirus type 16 (HPV16) is the most common high-risk type and isassociated with more than 50% cervical cancer cases as well as a number of headand neck cancer cases. The life cycle of HPV16 is strictly linked to celldifferentiation in the squamous epithelium with expression of the HPV16 earlygenes. The oncoproteins E6 and E7 are essential for preventing apoptosis andinducing prolifera
Combustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, whereCombustion, present in a vast majority of energy and material production as well as in transportation, represents a foundation of our modern society. To improve and optimize the applications relying on combustion demand a high level of knowledge, and an ability to simulate the combustion process. To do so three-dimensional Computational Fluid Dynamic (CFD) combustion simulations can be used, where
The promise of connecting agency and structure in studies of regional development is to disentangle causal effects and to better understand to what extent and how individuals, groups of individuals, and organisations can shape regional trajectories. This is not without challenges because agency and structure are deep theoretical constructs, which are not easily translated into empirical research.
BACKGROUND: Resistance to endocrine treatment in metastatic breast cancer is a major clinical challenge. Clinical tools to predict both drug resistance and possible treatment combination approaches to overcome it are lacking. This unmet need is mainly due to the heterogeneity underlying both the mechanisms involved in resistance development and breast cancer itself.METHODS: To study the complexity
The appreciation that cell interactions in tissues is dependent on their three dimensional (3D) distribution has stimulated the development of 3D cell culture models. We constructed an artificial 3D tumour by culturing human breast cancer JIMT-1 cells and human dermal fibroblasts (HDFs) in a 3D network of electrospun polycaprolactone fibres. Here, we investigate ECM components produced by the cell
The success of breast cancer therapies targeting the human epidermal growth factor receptor-2 (HER2) is limited by the development of drug resistance by mechanisms including upregulation of HER3. Having reported that HER2 expression and resistance to HER2-targeted therapies can be regulated by Junctional Adhesion Molecule-A (JAM-A), this study investigated if JAM-A regulates HER3 expression. Expre
‘The Static-99R is one of the most commonly used risk assessment instruments for individuals convicted of sexual offenses. It has been validated for use on many populations, but few studies specifically target and describe individuals with mental disorders. Additionally, research on the discriminative properties (how well the instrument separates recidivists from non-recidivists) of the instrument
The C-terminal-fragments of alpha1-antitrypsin (AAT) have been identified and their diverse biological roles have been reported in vitro and in vivo. These findings prompted us to develop a monoclonal antibody that specifically recognizes C-36 peptide (corresponding to residues 359–394) resulting from the protease-associated cleavage of AAT. The C-36-targeting mouse mono-clonal Immunoglobulin M (I
The generated magnitude of quadrature squeezing in a cavity-coupled ensemble, which is continuously driven using a coherent off-axis field, is theoretically explored. Using a truncated set of equations of motion derived from a Dicke Hamiltonian, steady-state quadrature squeezing of the cavity field is numerically calculated to approach a limit of -3dB, while frequency-modulated quadrature squeezin
We study the behaviour of an interacting particle system, related to the Bak–Sneppen model and Jante’s law process defined in Kennerberg and Volkov (Adv Appl Probab 50:414–439, 2018). Let N≥ 3 vertices be placed on a circle, such that each vertex has exactly two neighbours. To each vertex assign a real number, called fitness (we use this term, as it is quite standard for Bak–Sneppen models). Now f
