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Ecosystem impacts of hypoxia: thresholds of hypoxia and pathways to recovery

Coastal hypoxia is increasing in the global coastal zone, where it is recognized as a major threat to biota. Managerial efforts to prevent hypoxia and achieve recovery of ecosystems already affected by hypoxia are largely based on nutrient reduction plans. However, these managerial efforts need to be informed by predictions on the thresholds of hypoxia (i.e. the oxygen levels required to conserve

Analyzing an automotive testing process with evidence-based software engineering

Context: Evidence-based software engineering (EBSE) provides a process for solving practical problems based on a rigorous research approach. The primary focus so far was on mapping and aggregating evidence through systematic reviews. Objectives: We extend existing work on evidence-based software engineering by using the EBSE process in an industrial case to help an organization to improve its auto

Sodium and potassium monolayers on Be(0001) investigated by photoemission and electronic structure calculations

Photoemission spectra show that Be(0001) surface states shift to lower energy with increasing Na or K coverage in the monolayer range. At an intermediate monolayer coverage a quantum well state appears near the Fermi edge and shifts to lower energy reaching saturation energy at full monolayer coverage. At full monolayer coverage low energy electron diffraction shows 2 X 2 order for K while Na form

Problemet är att lagarna inte efterlevs

Det kinesiska samhället har blivit alltmer baserat på lag och rätt. Men tyvärr efterlevs inte lagarna. Kommunistpartiets maktmonopol är inte enda hindret för att implementera lagar. Med i bilden finns också svaga institutioner, oklara maktbefogenheter, korruption och bristande kunskaper i rättsfrågor. Den snabba ekonomiska utvecklingen har exempelvis lett till att lokalregeringar ser mellan fingra

Biocompatibility of a polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+) for neural implants.

The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a fle

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic an

Radiotherapy response in head and neck cancer - evaluation of the primary tumour site

Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring t

Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.

Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the resp

Contested administrations: Conflict resolution and the improvement of democracy

This research programme focuses on Democracy and Public Administration, with an emphasis on making democratic institutions better fit to handle contested issues through the use of insights from Peace and Conflict Studies. We are interested in public administration’s role in addressing and (possibly) resolving contested issues and conflicts, in order to increase equality, strengthen processes of in

Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery.

The mechanisms behind target vs. host cell recognition of the human antimicrobial peptide LL-37 remain ill-defined. Here, we have investigated the membrane disruption capacity of LL-37 using large unilamellar vesicles (LUVs) composed of varying mixtures of POPC, POPG and cholesterol to mimic target and host membranes respectively. We show that LL-37 is unable to induce leakage of entrapped calcein

Long-Term Evolution of a Long-Term Evolution Model

This paper reviews the 25-plus year history of significant developments of the GENESIS shoreline response model. Topics discussed are line sources and sinks of sand, representation of shore-normal structures including natural sand bypassing, wave transmission by and shoreline response to shore-parallel structures, seawalls, migrating longshore sand waves, seasonal variation by cross-shore sand tra

"None so queer as folk": Gendered expectations and transgressive bodies in leadership

This paper investigates the relationship between the body and leadership through a case study of a transgender leader. The study shows that the leader's body, presumed gender, and gendered appearance are salient markers that employees use to make sense of leaders and leadership, and that this gendered nature of leadership shows the deep roots of gender dichotomies and the heterosexual matrix that

Using HTK for Prolonged Pancreas Preservation Prior to Human Islet Isolation

Background. Histidine-tryptophan-ketoglutarate (HTK) has been established as an alternative to University-of-Wisconsin solution (UWS) for abdominal organ preservation, but data about HTK efficiency to preserve pancreata during prolonged cold ischemia time (CIT) are conflicting. In human islet transplantation, HTK provided similar isolation outcomes after short CIT. The present study aimed to inves

Isotope meteorology of cold front passages: A case study combining observations and modeling

This study investigates the role of below-cloud evaporation and evapotranspiration for the short-term variability of stable isotopes in near-surface water vapor and precipitation associated with central European cold fronts. To this end, a combination of observations with high temporal resolution and numerical sensitivity experiments with the isotope-enabled regional weather prediction model COSMO

Health-related quality-of-life in children with coeliac disease, measured prior to receiving their diagnosis through screening

Objective To compare the health-related quality-of-life (HRQoL) of children with screening-detected coeliac disease (CD), before they learned of their diagnosis, with that of children without CD and in those previously diagnosed with CD. Methods In a cross-sectional CD screening study ('ETICS': Exploring the Iceberg of Coeliacs in Sweden), of 10,041 Swedish 12-year-olds invited, 7567 (75%) consent