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TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, wh
Programmatic vaccination and screening are the reasons for this thesis. The practice of public health incorporating medicine’s cognitive contents along with contributions from other fields of human activities is basically a moral enterprise. It is important that limitations from the whole continuum of these interventions are recognized to retain credibility. The changing demands resulting from the
Zoophilous flowers often transmit olfactory signals to attract pollinators. In plants with unisexual flowers, such signals are usually similar between the sexes because attraction of the same animal to both male and female flowers is essential for conspecific pollen transfer. Here, we present a remarkable example of sexual dimorphism in floral signal observed in reproductively highly specialized c
Severe conditions and lack of cure for many amyloid diseases make it highly desired to understand the underlying principles of formation of fibrillar aggregates (amyloid). Here, amyloid formation from peptides was studied using Monte Carlo simulations. Systems of 20, 50, 100, 200 or 500 hexapeptides were simulated. Association kinetics were modeled equal for fibrillar and other (inter- and intra-p
Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower urinary tract and increases bladder stiffness. Here we tested the hypothesis that miR-29 is repressed in the bladder in outlet obstruction and that th
Effects of land use changes are starting to be included in estimates of life-cycle greenhouse gas (GHG) emissions, so-called carbon footprints (CFs), from food production. Their omission can lead to serious underestimates, particularly for meat. Here we estimate emissions from the conversion of forest to pasture in the Legal Amazon Region (LAR) of Brazil and present a model to distribute the emiss
Antibiotics are frequently administered orally to treat bacterial infections not necessarily related to the gastrointestinal system. This has adverse effects on the commensal gut microbial community, as it disrupts the intricate balance between specific bacterial groups within this ecosystem, potentially leading to dysbiosis. We hypothesized that modulation of community composition and function in
Abstract in German Dieser zweite im Rahmen des Forschungsprojekts „Folk Terminology and Musical Phenomena“ unter dem Überbegriff „European Voices“ von Ardian Ahmedaja herausgegebene Band verschreibt sich im Kern der Frage nach den unterschiedlichen Denotationen und Konnotationen vokaler Mehrstimmigkeit in Europa.
Understanding the uncertainty of climate models in space and time is necessary to help water resources managers and hydrologists in the selection of appropriate model for a specific application. In this paper, we use three separate methods to evaluate and compare the utility of 14 climate models for seven basins with area range of 2,656–26,355 km2 on the South Korean Peninsula. On the one hand, th
The ambition underlying this study is to provide a valid and efficient screening tool targeting accessibility problems in the ordinary housing stock. The study aims to test the feasibility and interrater agreement of a screening-tool version of the Housing Enabler in a real estate company practice context. Two rater pairs administer the screening in 35 apartments in a Swedish municipality. The ove
Rättssociologen Stefan Larsson tecknar vad han kallar en tankekarta runt beslutsprocesser och frågan om vem som bestämmer om vindkraften och på vilken kunskapsgrund detta görs. När det gäller beslutshierarkier beskriver Stefan Larsson vindkraftsutbyggnaden som en naturlig konflikt mellan nationella och lokala perspektiv, men menar att det är just kunskapstyperna som missas i debatten. Det är nämli
‘Nordic noir’ has increasingly become the prevalent term in the English-speaking world when referring to contemporary crime fiction – books, television serials and feature films – from the Nordic countries. With its unexpected international appeal and unforeseen longevity, the phenomenon has been the subject of, for instance, popular guide books and television documentaries for international audie
Background: An optimal dosage and infusion regime for protamine reversal of heparin after cardiopulmonary bypass is important. Methods: Protamine dosages of either 2mg/kg or 4mg/kg bodyweight were compared in 40 patients after first time coronary arterial bypass grafting. Protamine was infused with a syringe driver over 20 minutes. Arterial blood sampling was performed prior to and during surgery
Soil biological studies are often conducted on sieved soils without the presence of plants. However, soil fungi build delicate mycelial networks, often symbiotically associated with plant roots (mycorrhizal fungi). We hypothesized that as a result of sieving and incubating without plants, the total fungal biomass decreases. To test this, we conducted three incubation experiments. We expected total
Background Rheumatoid arthritis (RA) and osteoarthritis (OA) are important musculoskeletal diseases that the EUMUSC.NET project developed Standards of Care (SOC) for. Objective The purpose was to explore factors to enable successful implementation of the SOC for RA and OA. Methods A combined set of methods was used; a literature search, a European survey among patients, clinicians and policymakers
Access to second-line antiretroviral therapy (ART) for HIV-positive patients remains limited in sub-Saharan Africa. Furthermore, outcomes of second-line ART may be compromised by mortality and loss to follow-up (LTFU).
Energy-dispersive X-ray fluorescence (EDXRF) spectrometry is not adequate for the determination of some potentially hazardous trace elements, such as Cd, Cu, Ni and Pb at low concentration in PM2.5 atmospheric aerosol particles. Therefore, a method has been developed for the determination of these elements in atmospheric aerosol particles using high-resolution continuum source graphite furnace ato
