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Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries

Phosphodiesterase 5 (PDE5) is associated with migraine pathophysiology, stroke recovery and vasospasm treatment The potential vascular interplay of PDE5 inhibitors sildenafil, tadalafil and UK-114,542 was studied by intra- versus extra-luminal administration in rat middle cerebral arteries in vitro and on middle meningeal arteries in vivo. By Western blot PDE5 was detected in both cerebral and men

The impact of socio-economic status on net fertility during the historical fertility decline: A comparative analysis of Canada, Iceland, Sweden, Norway, and the USA.

We used micro-level data from the censuses of 1900 to investigate the impact of socio-economic status on net fertility during the fertility transition in five Northern American and European countries (Canada, Iceland, Norway, Sweden, and the USA). The study is therefore unlike most previous research on the historical fertility transition, which used aggregate data to examine economic correlates of

Design modifications of the uncemented Furlong hip stem result in minor early subsidence but do not affect further stability.

Background and purpose - Even small design modifications of uncemented hip stems may alter the postoperative 3-D migration pattern. The Furlong Active is an uncemented femoral stem which, in terms of design, is based on its precursor-the well-proven Furlong HAC-but has undergone several design changes. The collar has been removed on the Active stem along with the lateral fin; it is shorter and has

Prospective cohort study of metabolic risk factors and gastric adenocarcinoma risk in the Metabolic Syndrome and Cancer Project (Me-Can)

Little is known about the association between the metabolic syndrome (MetS) and the risk of gastric adenocarcinoma. The aim of this study was to investigate whether metabolic risk factors, together or combined, were associated with the risk of gastric adenocarcinoma. The Metabolic Syndrome and Cancer Project (Me-Can) is a pooling of prospective cohorts in Austria, Norway, and Sweden with informati

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry is a sensitive and specific method for identification of aerococci.

Conventional methods for the species determination of human pathogenic aerococci are not reliable. We show that matrix-assisted laser desorption ionization time-of-flight mass spectrometry correctly identifies aerococci to the species level and that it can be used to identify aerococci with high specificity in the diagnostic clinical microbiology laboratory.

Recent radiation in a marine and freshwater dinoflagellate species flock.

Processes of rapid radiation among unicellular eukaryotes are much less studied than among multicellular organisms. We have investigated a lineage of cold-water microeukaryotes (protists) that appear to have diverged recently. This lineage stands in stark contrast to known examples of phylogenetically closely related protists, in which genetic difference is typically larger than morphological diff

Structural phase transitions in neural networks.

A model is considered for a neural network that is a stochastic process on a random graph. The neurons are represented by "integrate-and-fire" processes. The structure of the graph is determined by the probabilities of the connections, and it depends on the activity in the network. The dependence between the initial level of sparseness of the connections and the dynamics of activation in the netwo

Smoothness-constrained time-lapse inversion of data from 3D resistivity surveys

Three-dimensional resistivity surveys and their associated inversion models are required to accurately resolve structures exhibiting very complex geology. In the same light, 3D resistivity surveys collected at multiple times are required to resolve temporally varying conditions. In this work we present 3D data sets, both synthetic and real, collected at different times. The large spatio-temporal d

Diagnostic criteria for Menière's disease.

This paper presents diagnostic criteria for Menière's disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. The classification includes two

Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection After Renal Transplantation: A Pooled Analysis From Three Randomized-Controlled Clinical Trials

Therapeutic drug monitoring (TDM) for tacrolimus (Tac) is universally applied. However, the concentrationeffect relationship for Tac is poorly defined. This study investigated whether Tac concentrations are associated with acute rejection in kidney transplant recipients. Data from three large trials were pooled. We used univariate and multivariate analysis to investigate the relationship between b

Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

Reprogramming of somatic cells into pluripotency stem cell state have opened new opportunities in cell replacement therapy and disease modeling in a number of neurological disorders. It still remains unknown, however, to what degree the grafted human induced pluripotent stem cells (hiPSCs) differentiate into a functional neuronal phenotype and if they integrate into the host circuitry. Here we pre

The Comparison of Trial Data-Based and Registry Data-Based Cost-Effectiveness of Infliximab Treatment for Rheumatoid Arthritis in Sweden Using a Modeling Approach

Objective: To evaluate the precision of the predictive cost-effectiveness assessment based on a phase 3 clinical trial with infliximab for the treatment of rheumatoid arthritis in Swedish clinical practice. Methods: Three patient cohorts were identified: the patients included in the infliximab trial (ATTRACT), patients initially treated with infliximab from a Swedish registry (STURE), a subset of

Breakdown of ionic character of molecular alkali bromides in inner-valence photoionization

The inner-valence region of alkali bromide XBr (X=Li, Na, K, Rb) vapours has been studied experimentally by means of synchrotron radiation excited photoelectron spectroscopy. Experimental spectra were analyzed by comparing them with available theoretical results and previous experiments. Ionic character of alkali bromides is seen to change in the inner-valence region with increasing atomic number

The impact of price reductions on individuals' choice of healthy meals away from home

Food high in energy but low in nutritional value is an important contributor to several serious illnesses, and one type of food that is particularly high in energy but low in nutrition is food consumed away from home. In this paper, we examine the demand and willingness to pay for healthy, Keyhole-labelled meals. A Keyhole-labelled meal is particularly low in energy, fat, sugar and salt, but parti