BACKGROUND Exome sequencing in hundreds of thousands of persons may enable the identification of rare protein-coding genetic variants associated with protection from human diseases like liver cirrhosis, providing a strategy for the discovery of new therapeutic targets. METHODS We performed a multistage exome sequencing and genetic association analysis to identify genes in which rare protein-coding

It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each

OBJECTIVE: To investigate the relation between biomarkers of inflammation and subsequent development of giant cell arteritis (GCA).METHOD: Participants in the population-based Malmö Diet Cancer Study (MDCS; N = 30447), established 1991-1996, who were subsequently diagnosed with GCA, were identified in a structured process. GCA-free controls, matched for sex, year of birth, and year of screening we

Behavioural insights are increasingly shaping the design, implementation and evaluation of energy policies. This Special Issue aims to broaden and strengthen the evidence base, and policy value of behavioural insights in the context of sustainable energy use. It showcases a plethora of behavioural issues that can help to improve our understanding of the decision-making ‘black box’ of energy users

Long non-coding RNAs (lncRNAs) are involved in breast cancer pathogenesis through chromatin remodeling, transcriptional and post-transcriptional gene regulation. We report robust associations between lncRNA expression and breast cancer clinicopathological features in two population-based cohorts: SCAN-B and TCGA. Using co-expression analysis of lncRNAs with protein coding genes, we discovered thre

Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Metho

BACKGROUND: Antibody-based constructs for molecular imaging and therapeutic delivery provide promising opportunities for the diagnosis and treatment of atherosclerosis.OBJECTIVES: The authors aimed to generate and characterize immunoglobulin (Ig)G monoclonal autoantibodies in atherosclerosis for targeting of novel molecular determinants.METHODS: The authors created hybridomas from an unimmunized l

In the search for efficient test methods for distributed real-time systems, an experiment is conducted that investigates the impact on the lead-time required to identify, a defect, depending on what information is available. One group of experiment participants were given a system monitoring trace, while a control group were given node monitoring traces. The information made available in the two s

The purpose of my article is to highlight the development and activities of the Catholic traditionalist minority groups and discuss their importance in today’s Catholic Church. The traditionalist movement started as a reaction to the reforms implemented as a result of the Second Vatican Council (1962-1965), which for many conservative minded Catholics appeared as a departure from Catholic faith anThe purpose of my article is to highlight the development and activities of the Catholic traditionalist minority groups and discuss their importance in today’s Catholic Church. The traditionalist movement started as a reaction to the reforms implemented as a result of the Second Vatican Council (1962-1965), which for many conservative-minded Catholics appeared as a departure from Catholic faith an

One of the great challenges within software testing is to know ira test suite covers a program sufficiently. Mutation analysis is presented as an approach to address that challenge. Faulty versions, or mutants, are created and it is investigated if the test suite is able to discover the defects. The technique is mostly applied to the unit level testing of software programs. In this paper, mutation

System verification and validation are performed to secure that a system fulfils the different quality aspects, such as reliability, functionality, maintainability, performance and user friendliness. Since the verification and validation activities take a large share of the total project budget, efficiency and effectiveness are key issues. In this paper, a method is presented for application of th

This article builds upon literature on materialities of care and departs from a relational view of care and place. Using the concept of atmosphere, it investigates how care practices are situated spatially and temporally in pharmacies. In many countries, pharmacies are viewed as an important sector in formal healthcare systems. Rarely discussed in pharmacy literature is the affective and embodied

Alumni engagement plays a crucial role in driving innovation in university-based entrepreneurship ecosystems. We employ an inductive, informant-centric research design to explore the processual dynamics surrounding the early alumni engagement of entrepreneurship graduates and how these translate into enterprising behaviors that foster technology transfer and knowledge-intensive entrepreneurship. O