We introduce a family of stochastic optimization methods based on the Runge–Kutta–Chebyshev (RKC) schemes. The RKC methods are explicit methods originally designed for solving stiff ordinary differential equations by ensuring that their stability regions are of maximal size. In the optimization context, this allows for larger step sizes (learning rates) and better robustness compared to e.g. the p

It is well known that Gaussian polynomials (i.e., q-binomials) describe the distribution of the [Formula presented] statistic on monotone paths in a rectangular grid. We introduce two new statistics, [Formula presented] and [Formula presented]; attach “ornaments” to the grid that scramble the values of [Formula presented] in specific fashion; and re-evaluate these statistics, in order to argue tha

Objective: Huntington's disease (HD) is an inherited neurodegenerative disease with motor, cognitive and psychiatric symptoms. Non-motor symptoms like depression and altered social cognition are proposed to be caused by dysfunction of the hypothalamus. We measured the hypothalamic neuropeptide oxytocin in plasma and cerebrospinal fluid (CSF) in a cohort of HD gene expansion carriers (HDGECs), comp

Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components. However, their role in hematopoiesis regeneration and leukemia is unknown. Laminin α4 (Lama4), a major receptor-binding chain of several laminins, is

Imaging is an integral part of breast cancer diagnosis, staging and follow-up. Breast imaging is also important for radiation therapy planning. The radiation oncologist needs to review patient’s imaging (e.g. mammography) to evaluate the extent of disease (for radiation planning, not for diagnostic purposes) and for treatment planning. Pre-treatment imaging is the key for planning radiation target

OBJECTIVES: To evaluate the efficacy of intensive smoking cessation interventions (ISCIs) directly compared with shorter interventions (SIs), measured as successful quitting.METHOD: Medline, Embase, the Cochrane Library and CINAHL were searched on 15 October 2021. Peer-reviewed randomised controlled trials (RCTs) of adult, daily smokers undergoing an ISCI were included. No setting, time or languag

Rabi oscillations are periodic modulations of populations in two-level systems interacting with a time-varying field 1. They are ubiquitous in physics with applications in different areas such as photonics 2, nano-electronics 3, electron microscopy 4 and quantum information 5. While the theory developed by Rabi was intended for fermions in gyrating magnetic fields, Autler and Townes realized that

Dynamic resource management is a difficult problem in modern microservice applications. Many proposed methods rely on the availability of an analytical performance model, often based on queueing theory. Such models can always be hand-crafted, but this takes time and requires expert knowledge. Various methods have been proposed that can automatically extract models from logs or tracing data. Howeve

The design and evaluation of national HIV programs often rely on aggregated national data, which may obscure localized HIV epidemics. In Ethiopia, even though the national adult HIV prevalence has decreased, little information is available about local areas and subpopulations. To inform HIV prevention efforts for specific populations, we identified geographic locations and drivers of HIV transmiss

The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which

BACKGROUND: Increasing number of individuals will have first-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.METHODS: In this Swedish nationwide cohort study, rate ratio (RR) and cumulative incidence of C

Nitrogen (N) availability is a powerful controller of soil carbon (C) cycling in temperate forests, affecting plant productivity and microbial activities. Enhanced rhizosphere input from increased plant productivity can stimulate the decomposition of native soil organic matter (SOM), termed the “priming effect”, with an effect size that is affected by N availability. Using soils from N-fertilizati