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Parkinsons sjukdom är en kronisk neurodegenerativ sjukdom karaktäriserad avtypiska motoriska symtom i form av långsamma rörelser, muskelstelhet ochvilotremor. Dessa symtom orsakas av en brist på signalsubstansen dopamin i deområden av hjärnan som kontrollerar rörelser (hjärnbarken, basala ganglierna ochthalamus). Parkinsonmedicin, varav det mest effektiva är levodopa, mildrarsymtomen genom att ökaParkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. Thiscompound exerts its motor effects by stimulating dopamine D1 and D2 receptors,whose expressio

Syftet med den här rapporten är att bidra till en ökad förståelse av handelns innovativa förmåga och att bidra till ett för handeln anpassat sätt att leda och organisera innovation. Tillsammans med de företag som har varit delaktiga i forskningsprojektet vill vi dela med oss av de utmaningar och lösningar som vi har identifierat, diskuterat och analyserat i relation till den existerande kunskapen

New approaches based on -omics technologies can identify biomarkers and processes regulated in response to xenobiotics, and thus support toxicological risk assessments. This is vital to meet the challenges associated with “cocktail effects”, i.e. combination effects of chemicals present simultaneously in a product, our environment, and/or our body. For plant protection products (PPPs), investigati

Background: Little is known about how PFAS concentrations in human milk change over the course of lactation, although this is an important determinant of cumulative infant exposure from breastfeeding.Objective: To estimate changes in PFAS concentrations in human milk over the course of lactation in a population with a wide range of exposure from background-to high-exposed.Methods: We measured PFAS

Languages differ in how grammatically salient gender is. We explored if grammatically gender-neutral pronouns in Finnish and Turkish, two grammatically genderless languages, are gender neutral or male biased, thereby activating male, rather than female, exemplars. We also tested whether differences in national level gender equality influence the male bias. Results indicated a male bias in both lan

Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with

Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations fr

This abstract describes the decomposition of a matrix representing a scattering dyadic into characteristic modes. Scattering dyadic, as compared to conventionally used impedance matrices, are independent of numerical method used to compute them and the same characteristic mode formulation can be used for decomposition of composite and inhomogeneous materials. The utilization of scattering dyadic m

It has been shown that a partially reflective surface (PRS) antenna with a larger reflection magnitude has a higher antenna gain, based on practical design examples. In this paper, PRS antennas with different reflection magnitudes are analyzed using an intuitive ray-tracing model. It is derived that the larger reflection magnitude enables a smaller phase delay and a more uniform magnitude distribu

A novel synthesizing procedure is introduced and employed to extract locally-optimal cloaking devices. Their performance is compared with fundamental bounds found using a convex optimization approach. The optimization method is based on a method-of-moments paradigm utilizing rank-1 updates of the structure iteratively performed based on a greedy algorithm. This approach produces locally optimal sh

The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biolog

This abstract presents the versatility and computational effectiveness of characteristic mode decomposition based on the transition matrix. The described treatment is valid for all lossless and linear material distributions and is independent of the numerical method used to resolve a particular scattering scenario.

Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading to increased IOP, which can manifest as medication resistance as disease progresses. To identify physiological modulators of IOP, we performed genome- and exome-wide association an