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The activation of dendritic cells (DCs) by microbes is mediated by pattern recognition receptors including the Toll-like receptors (TLR). Bacterial lipopolysaccharide acts via TLR4 whereas peptidoglycan and lipoprotein responses are mediated by TLR2. It is generally accepted that TLR binding to microbes occurs at the cell surface but this has not been directly demonstrated for human DCs. We show h

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf

Households will play an important role in saving electricity in the future. Behavioural aspects in using white goods and other electric appliances are important as are the reasons for buying new white goods and a number of other appliances for cooking and washing. In a Swedish study three important aspects of energy use in households , Washing/drying Laundry, Cooking and Eating, and Information an

Abstract in Danish Denne artikel rejser spørgsmålet om grunderne til neuropsykiatriens dominans inden for feltet mentala forstyrrelser. I kapitlets første del søges orsagerne i neuropsykiatriens videnskablige inhold. Diskussionen vil især dreje sig om neuropsykiatrins klassifikations- og førklaringssystem. Det vil bland andet framgå, at neuropsykiatriens fenomenologisk baserede klassifikationer (D

Popular Abstract in Swedish Undersøkelsen omfatter 44 skandinaviske personer med Laurence-Moon-Bardet-Biedl syndrom. Disse personer hadde netthinne degenerasjon og minst ytterligere 2 av de øvrige tradisjonelle tegn på lidelsen: overvekt, overtallige fingre og tær, mangelfullt utviklede kjønnsorganer og nedsatt intelligens. Undersøkelsen viste at pasientene fikk nattblindhet og avtagende syn i barThe study included 44 Scandinavian individuals with the autosomal recessive inherited Laurence-Moon-Bardet-Biedl syndrome. Inclusion criteria were retinal dystrophy plus at least 2 more of the remaining traditional cardinal signs of the syndrome: obesity, polydactyly, hypogenitalism and mental retardation. The study showed that the patients had an early onset of night blindness and a poor visual p

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We show how a difference in the correlation length longitudinally and transversely, with respect to the jet axis in e+e- annihilation, arises naturally in a model for Bose-Einstein correlations based on the Lund string model. The difference is more apparent in genuine three-particle correlations and they are therfore a good probe for the longitudinal stretching of the string field.