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The growing field of biotechnology is in constant need of binding proteins with novel properties. Not just binding specificities and affinities but also structural stability and productivity are important characteristics for the purpose of large-scale applications. In order to find such molecules, libraries are created by diversifying naturally occurring binding proteins, which in those cases serv
Context: Estrogens regulate bone mass by binding to the estrogen receptor (ER)-alpha as well as ER-beta. The specific ER -cofactor retinoblastoma-interacting zinc finger protein (RIZ)-1 enhances ER alpha function in the presence of estrogen. Objective: The objective of the study was to determine whether a RIZ P704 insertion (+)/ deletion (-) (indel) polymorphism modulates the impact of estradiol o
We have identified a novel von Willebrand factor/fibrinogen/selectin-independent, platelet adhesion-promoting function of vascular PG-M/versicans that may be relevant in normal venous thrombosis and critical in atherosclerotic conditions. A purification scheme was devised to obtain vascular versicans, which by biochemical, immunochemical, and ultrastructural means were asserted to be 1) composed p
A methodology for the rapid and quantitative analysis of phosphorylation sites in proteins is presented. The coupling of capillary high-performance liquid chromatography (HPLC) to electrospray ionization mass spectrometry (ESI-MS) allowed one to distinguish phosphorylation sites based on retention time and mass difference from complex peptide mixtures. The methodology was first evaluated and valid
Background: We evaluated the efficacy and safety of low-dose budesonide/formoterol, 80 mug/4.5 mug, bid in a single inhaler (Symbicort Turbuhaler; AstraZeneca; Lund, Sweden) compared with an increased dose of budesonide, 200 mug bid, in adult patients with mild-to-moderate asthma not fully controlled on low doses of inhaled corticosteroid alone. Methods: All patients received budesonide, 100 jig b
As the child grows up it becomes more and more a part of the adult world of communication and understanding. Semiotic studies of the development of signs in children are remarkably few, as if the mere existence of signs were taken for granted. The studies in the child’s cognitive development conducted by Piaget and Vygotsky in the last century still have the capacity to influence theoretical claim
Popular Abstract in Swedish Svenska Pommerns historia är en del av den svenska historien. Mellan 1648 och 1815 hörde den tyska Östersjöprovinsen till det svenska väldet. Denna avhandling skildrar människorna och deras syn på Sverige under de sista hundra åren av svensk tillhörighet mellan 1720 och 1815. Hur påverkades provinsens invånare av att å ena sidan räkna sig till den tyska kulturen och å aBetween 1648 and 1815, Swedish-Pomerania, at the Baltic shore, belonged to the crown of Sweden. It was both a part of the Holy Roman Empire of German Nation and the Swedish realm. The port town of Stralsund played a key roll in the Swedish economy at the Baltic Sea, whereas the university town of Greifswald was the intellectual centre. On a cultural level, this situation opened up for a double ins
Abstract is not available.
In the present thesis the development and application of a novel laser diagnostic system for high speed spectroscopic imaging of turbulent combustion phenomena is presented. The system is capable of recording sequences of up to 8 images with a separation between consecutive images as short as microseconds. The system allows a number of established laser diagnostic techniques to be used, extending
Popular AbstractLandsbygdens landskap förändras ständigt. Ekonomi, teknik och politik används ofta för att förklara det som sker, men ingen av dessa krafter verkar direkt i landskapet. I praktiken är det beslut som fattas lokalt av enskilda brukare och markägare som sätter spår. Landskapet är där sammanvävt med den sociala miljön, och markanvändningen en integrerad del av den enskildes liv. Hur seFarmers and Landscape. Owners and farmers relations to their land, and the prospects for sustainable land use. In a transition towards sustainability, rural land use is of certain interest, owing to the environmental impact of modern farming and forestry, and also to its potential role in a recycling society. The prospects for sustainable land use depend on the farmers. Their conception of sustai
This article deals with multi-unit questioning turns used in different genres of institutional interactions. Analyzing in detail a corpus of about 400 multiunit questions from health care interactions, court trials, police interrogations, and social welfare office talks from Sweden and Finland (all in the Swedish language), a number of sequential patterns are established. Some of these sequential
As the complexity of social and political interaction becomes increasingly over-whelming it is only natural that the pragmatic, technocratic, and expert-driven character of contemporary policy-making is even further consolidated. Though making use of existing knowledge this approach may lead to a deprivation of the democratic debate as the time horizons are shortened and the number of significantl
In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no suc
Three adult volunteers (2 males and I female) have ingested radioactive caesium in two edible forms in order to compare the gastrointestinal uptake and the subsequent short-term and long-term biokinetics. Foodstuffs made of fresh-water fish or mushrooms from regions in Sweden of high Cs-137 deposition was ingested together with a (CsCl)-Cs-134-solution mixed with soft drinks. Whole-body countings
The effects of i.v. calcitonin gene-related peptide (CGRP) on regional blood flow, vascular resistance, heart rate and cardiac output in cats were studied using the microsphere method. Three series of experiments were performed. In the first there was no pre-treatment of the animals. In the second the animals were pre-treated with indomethacin (5 mg kg-1) in order to prevent the formation of prost
