Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. Currently, the absence of efficacious and safe methods to deliver nucleic acids to intracellular sites of action is the main impediment to th

The aim of this doctoral thesis is to contribute to the debate on the importance of diet and disease in explaining the mortality decline and the general literature of the long-term effects of early life conditions. Using individual-level data from Southern Sweden for 1813 to 1968, this work measures the impacts of grain prices during the foetal stage and infant mortality rates during the year of b

In the Tunisian semiarid area, water erosion processes have led to negative economic and environmental consequences in a context of limited water resources. To characterize and predict these degradation phenomena, a comprehensive high-resolution data base on erosive rainfall, together with siltation records for 28 small reservoirs were analyzed. The studied small reservoir network displays a gener

Developing useful biological isoscapes for areas of the world is a priority. This is the case for Mexico that hosts a large percentage of North America's Neotropical migrant birds. Here we investigated the use of House Sparrow (Passer domesticus) feathers to create a spatially explicit feather deuterium isoscape for that country using samples (n=461) that were collected across Mexico. Considerable

This paper introduces a model of the atrioventricular node function during atrial fibrillation (AF), and describes the related ECG-based estimation method. The proposed model is defined by parameters that characterize the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two atrioventricular nodal pathways, the refractory periods of these pathways, and the p

Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our re

Samples of compositionally (highly) asymmetric diblock copolymers and, also, mixtures of diblock and triblock copolymers (the latter obtained as end-coupling products of two diblock molecules of the mixture), composed of (a) monodisperse majority block(s) of poly(styrene) (PS) and a polydisperse minority block of poly(methacrylic acid) (PMAA), microphase separate into spherical PMAA microdomains,

Abstract. We consider a of the forest fire model on graph G, where eachvertex of a graph becomes occupied with rate one. A fixed vertex v0 is hit by lightning with the same rate, and when this occurs, the whole cluster of occupied vertices containing v0 is burnt out. We show that when G = Z+, the times between consecutive burnouts at vertex n, divided by log n, converge weakly as n → ∞ to a random

Atmospheric aerosol samples from a boreal forest (Hyytiala, April 2007), a rural site in Hungary (K-puszta, summer 2008), a polluted rural area in Italy (San Pietro Capofiume, Po Valley, April 2008), a moderately polluted rural site in Germany located on a meadow (Melpitz, May 2008), a natural park in Spain (Montseny, March 2009) and two urban background locations (Zurich, December 2008, and Barce

Broad public contention against nuclear energy can be observed as a new phenomenon in Japanese society after the 2011 Fukushima Daiichi nuclear power plant accident. This study aimed to identify a sufficient explanation about why the emergence of such a protest movement only occurred after the direct experience of a critical event and did not happen before. Discrediting a sole and simple grievance

Most bacteriophages are known to inject their double-stranded DNA into bacteria upon receptor binding in an essentially spontaneous way. This downhill thermodynamic process from the intact virion to the empty viral capsid plus released DNA is made possible by the energy stored during active packaging of the genome into the capsid. Only indirect measurements of this energy have been available until

This article examines how Colonialism — as a cosmologically informed process of profound existential and political implications — is understood, experienced and conceptualized by Aymara shaman activists. By contextualizing the term Colonialism this article reassesses not only the supposed postcolonial nature of the world, but also the distinctions between colonialism and coloniality.

The status of preservation of the historic brain specimen of C.H. Fuchs, C.F. Hermann, P.G. Lejeune Dirichlet, and C.F. Gauss from R. Wagner's collection from the 19th century has been investigated using modern magnetic resonance imaging (MRI) techniques. A brief report on their properties and current state of preservation is given.

This article assesses the potential and the limitations of Thailand's proposed policy which would have local governments buy back targeted waste electronic and electrical equipment (WEEE) from households at designated locations. The proposal relies on the premise that a monetary incentive at the time of disposal is needed to gain participation from households which would otherwise sell to private

In hot humid regions the high outdoor temperature has negative effects on the indoor temperature of buildings that are not designed to cope with the local climate. This leads to discomfort for the occupants. In Maputo City, the capital of Mozambique, electrical devices such as fans and air conditioners are used to obtain a comfortable indoor climate. The cost of electricity is a problem for consum

was spring and autumn for the sites characterized by summer droughts (southern sites) and (peak) summer for the Alpine and northern study sites. This general pattern was interrupted by grassland management practices, that is, mowing and grazing, when the variability in NEE explained by PPFD decreased in concert with the amount of aboveground biomass (BMag). Temperature was the abiotic influence fa

A lysimeter method was evaluated for its suitability in gas emission studies by studying the effect of temperature on CO2 emissions (dark respiration) from cultivated peat soils. The study was carried out with organic soils from two locations in Sweden, a typical cultivated fen peat with low pH and high organic matter content (Orke) and a more uncommon fen peat with high pH and low organic matter

Context. The astrometric solution for Gaia aims to determine at least five parameters for each star, representing its position, parallax, and proper motion, together with appropriate estimates of their uncertainties and correlations. This requires at least five distinct observations per star. In the early data reductions the number of observations may be insufficient for a five-parameter solution,