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Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of s
The social sciences have many different understandings of ‘normative power’, but in European Union (EU) studies normative power has three particular meanings. The first meaning of normative power is its emphasis on normative theory, that is, how we judge and justify truth claims in social science. The second meaning of normative power is as a form of power that is ideational rather than material o
Abstract in SpanishEn este artículo se propone un acercamiento didáctico a la enseñanza del Pretérito Perfecto Compuesto (PPC) en contextos de español como lengua extranjera. Se analizan algunos problemas de la visión tradicional sobre el tema y se plantea que el concepto de referencia genérica propuesto en Henderson (2010) da una respuesta más coherente a usos que la bibliografía suele adjudicar This article proposes a didactic approach to teaching the compound past tense that is known in English as “Present Perfect” (PPC for its initials in Spanish) in contexts of Spanish as a Foreign Language. It analyses some issues concerning the traditional view on the subject and suggests that the concept of generic reference proposed by Henderson (2010) provides a more coherent explanation for some
The idea of being civilian, military, and civilizing at the same time is undoubtedly very seductive to the armies of academics now writing on EU military force. It is tempting to think that the EU can have-its-cake-and-eat-it-too in militarizing its normative power. In contrast, in my reconsideration of normative power Europe I suggest that militarization of the EU need not necessarily lead to the
This paper presents an analysis of how library professionals in Sweden and Denmark perceive the democratic role of the library profession in the polarised political landscape of today. Relating to research on the democratic role of libraries, professional ethics and cultural policies, empirical data was gathered through seven group interviews with library professionals from eleven local libraries
The use of material extrusion (MEX) has increased rapidly due to the affordability of 3D printers. This has led to a growing demand for improved print quality, high fidelity, strength, or fast print times. In this study, a non-planar approach for better surface quality is investigated. The hardware of a 3-axis MEX printer was developed together with testing new software for non-planar slicing. The
BACKGROUND: Continuity of care is important for patients with chronic conditions. Assigning patients to a named GP may increase continuity.AIM: To examine if patients who were registered with a named GP at the onset of their first chronic disease had higher continuity at subsequent visits than patients who were only registered at a practice.DESIGN & SETTING: Registry-based observational study
Taza in Spanish refers to cups and mugs in English, whereas glass refers to different glass types in Spanish: copa and vaso. It is still unclear whether such categorical distinctions induce early perceptual differences in speakers of different languages. In this study, for the first time, we report symmetrical effects of terminology on preattentive indices of categorical perception across language
A workshop and gallery space that hosts artists and local in co-creative processes.
In this study we report on reactive Large Eddy Simulations (LES) of flow and combustion in the US Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques as well as numerically using hybrid RANS/LES. Here, we build on the existing
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study usin
In past human populations, atherosclerosis has been identified in mummies from different regions of the world, and from a range of chronological periods (for extensive reviews see Chapters 3 and 4). This current study from Sweden aims to contribute to the limited evidence for atherosclerosis associated with human skeletal remains by presenting examples of atherosclerosis in another part of the bod
In this paper, a factor-augmented version of the New Keynesian Phillips curve (NKPC) is assessed using a data set comprised of a large panel of European Union (EU) member countries. The factor-augmentation is natural given that country-level inflation rates are highly co-moving. The presence of unattended common factors is important because it raises the issue of omitted variables bias, as the rea
Addressing the need for modulated spin configurations is crucial, as they serve as the foundational building blocks for next-generation spintronics, particularly in atomically thin structures and at room temperature. In this work, we realize intrinsic ferromagnetism in monolayer flakes and tunable ferro-/antiferromagnetism in (Fe0.56Co0.44)5GeTe2 antiferromagnets. Remarkably, the ferromagnetic ord
Objective. Non-neuronal acetylcholine (ACh) has been suggested to be a mediator for the development of various types of cancer. We analyzed a possible role for this molecule in carcinogenesis and/or progression of human colon cancer, in patient biopsies harvested from the colon during surgery. We addressed whether ACh synthesis (by choline acetyltransferase) and/or degradation (by ACh esterase), a
We used immunochemistry to demonstrate expression of acetylcholine's nicotinic α7-receptor subtype in human colon cancer cell line HT-29. Moreover, RT-PCR and immunochemistry showed that choline acetyltransferase and acetylcholine esterase, the enzymes responsible for acetylcholine synthesis and degradation, respectively, localise in HT-29 cells. Bromoacetylcholine bromide, an inhibitor of choline
