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A general formulation for the distribution problem is presented, which is applicable to frequency distributions of subgrid-scale variables and hydrometeor size distributions, as well as to probability distributions characterizing data uncertainties. The general formulation is presented based upon two well-known basic principles: the maximum-entropy principle and the Liouville equation. The maximum

Global environmental challenges, coupled with growing material resource consumption, are exacerbated by an increasingly hostile geopolitical environment and the securitisation of politics. The circular economy (CE) proposes a solution to address these challenges by transforming production and consumption systems, which has sparked significant interest in the concept among scholars, policymakers, a

ObjectivesDespite regularly being found in blood cultures, there are few studies of bloodstream infection (BSI) with Citrobacter. In this population-based study, the aim was to explore patient characteristics, outcome, and incidence in a publicly funded single payer setting.MethodsPatients with growth of Citrobacter in blood culture were identified through the clinical microbiology laboratory in L

Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic and predictive information. Methods We analyzed α/β T-cell receptor (TCR) clonality using RNA-sequencing of bulk frozen tumor tissue from 182 patien

Self-care interventions for sexual and reproductive health (SRH), including HIV self-testing, self-injected contraception and self-managed abortion, offer promising pathways to advance universal health coverage, particularly in low- and middle-income countries. While often framed as cost-saving measures, this paper argues that self-care should be understood as a strategic investment in health syst

Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat

Genomgång av samtliga de tillfällen då Carl von Linné omnämns i Carl Tersmedens memoarer inklusive kommentarer, bland annat rörande kronologiska diskrepanser.

Trimethylolpropane (TMP) is an important industrial chemical used to produce various value-added chemicals and polymers. In this study, both biobased butyraldehyde and formaldehyde were produced by the incomplete oxidation of bio-1-butanol and biomethanol, respectively, and were then used to produce a biobased TMP. High selective incomplete oxidation of primary alcohol to aldehyde is a challenging

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Cytostatic pharmaceuticals are not completely removed in wastewater treatment plants (WWTPs) and may affect aquatic ecosystems. Their quantification is challenging due to variations in wastewater characteristics, which influence analytical performance. An analytical procedure has been developed, based on solid-phase extraction and liquid chromatography coupled with tandem mass spectrometry, for th

We study a network formation game where n players, identified with the nodes of a directed graph to be formed, choose where to wire their outgoing links in order to maximize their PageRank centrality. Specifically, the action of every player i consists in the wiring of a predetermined number di of directed out-links, and her utility is her own PageRank centrality in the network resulting from the

High-risk neuroblastoma (NB) is a rare, solid childhood cancer with poor prognosis due to treatment resistance and metastasis. Improved patient outcome is dependent on the understanding of the resistance mechanisms and subsequent development of novel treatment options.In Paper I, we established a clinically relevant in vivo treatment protocol using current standard-of-care chemotherapy (COJEC). We

Over the past fifteen years, Rwanda has made significant progress in formalizing mining rights and the production processes of 3Ts minerals in its artisanal and small-scale mining (ASM) sector. However, labour relations remain largely unregulated. This study analyses ASM activities through the production process observations, document reviews, and interviews with key informants involved in the sec

En historia om fyra framstående finsk-amerikanska musiker i början av 1900-talet: Einar Swan, Sylvester Ahola, Wäinö Kauppi och Emil Hurja.A history of four prominent Finnish-American musicians in the early 20th century: Einar Swan, Sylvester Ahola, Wäinö Kauppi and Emil Hurja.