Sialinsyra är ett samlingsnamn för enkla sockerarter som har en ryggrad bestående av 9 kol, med bland annat en karboxylsyra och en glycerolsvans. Sialinsyra förekommer naturligt i kroppen hos däggdjur. Hos människan är Neu5Ac den mest förekommande sialinsyran, och när man refererar ospecifikt till sialinsyra brukar det vara Neu5Ac som avses. Neu5Ac går att hitta i änden av de kolhydratkedjor som Sialic acids are a family of 9-carbon sugars which contain a carboxyl group and a glycerol chain. Neu5Ac is the most common sialic acid in humans and occurs at the terminal position of glycoconjugates covering the cell surface. Neu5Ac is involved in several different processes in the human body and plays an important role in several physiological conditions and pathogenic diseases. Sialic acid is

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

Power converters of DC-DC nature are pivotal to supplying power in electronics, charging equipment, and renewable energy integration along with AC-DC converters. They are frequently used in most of the power supplies of electronic devices as well as dedicated high-energy functionalities including charging battery cells, electroplating, and welding. Furthermore, DC-DC switching regulators not only

Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca

Objective To compare work loss after starting tumour necrosis factor inhibitors (TNFi), rituximab, abatacept or tocilizumab in patients with rheumatoid arthritis (RA). Methods We used data from the Swedish Rheumatology Quality Register to identify patients aged 19-62 years who were treated with TNFi (n=15 093), rituximab (n=2123), abatacept (n=1877) or tocilizumab (n=1720) between 2007 and 2020. D

Converters of AC-DC nature are pivotal to supplying power in electronics, charging equipment, and renewable energy integration. A closed-loop Cuk converter with switched capacitor network and PID controller was proposed in this paper to mitigate the limitations of open circuit Cuk converter topology to ensure improved power factor from input along with low distortion in output, making it ideal for

The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. Transhumanism was an attempt to unite a more traditional humanistic view of the human as containing some form of core essence or potential with an evolutionary point of view of humans as a work in progress. Before humans, natural selection had bee

With increasing environmental awareness, building materials and their impact on the environment are increasingly coming into focus. This study presents a framework for comparing Life Cycle Assessment (LCA) through A1 - A5 stages from the perspective of Global Warming Potential (GWP) to assess the climate change potential of three facade systems of different building types (villas, medium-sized bui

In 2022 the Serbian Orthodox Church managed to seal off two of its longstanding ecclesial conflicts in former Yugoslavia and put an end to open hostility. The end of the conflicts seems to have been prompted as a response to the War in Ukraine. This chapter explores the Orthodox diplomacy in Montenegro and Macedonia and how it relates to the geopolitical and ecclesial role of the Serbian Orthodox

Research on the rhythmic communication (RC) of nonhuman animals is undergoing a period of great effervescence and expansion. Here, we synthesize this rapidly growing literature with the aim of mapping RC forms and usage contexts in an unprecedented diversity of taxa, spanning insects, fish, frogs, birds and mammals. We see this as a first large-scale effort toward charting the functional and struc

Abstract in French:Cette recherche s'intéresse à la mobilisation transnationale de la diaspora autour du vote externe et à l'implication des organisations diasporiques dans le processus électoral du pays d'origine. Plusieurs approches expliquent la transnationalisation politique des groupes diasporiques ; cependant, elles ne parviennent pas à clarifier (1) comment certains moments historiques (parThis research is concerned with transnational diaspora mobilisation around external voting and diaspora organisations’ involvement in the homeland electoral process. There are several approaches that explain the political transnationalisation of the diasporic groups; yet, they fail to clarify (1) how some historical moments (e.g., extending the voting right to non-resident nationals) can generate

The catalytic conversion of carbon dioxide (CO2) to methanol over Cu/ZnO catalysts is expected to become valuable for recycling CO2. The nature of the Cu-Zn interplay remains a subject of intense debate due to many different Zn species encountered in Cu/ZnO catalysts. In this study, we designed a Cu-Zn catalyst by ion-exchanging Cu into CIT-6, a crystalline microporous zincosilicate with the BEA*

Introduction: Out-of-pocket health expenditures (OOPE) are an inefficient and inequitable means of health financing. Identifying the factors driving these expenditures is crucial to design effective prepayment schemes. This study uses Cambodia—a country with high OOPE and prevalent informal employment—as a case study to analyse the relative contributions of healthcare, health, and social factors t

Artificiell intelligens blir alltmer populärt och används idag från allt till datorseende och självkörande bilar till chatbot assistenter som OpenAI:s världskända ChatGPT. Kärnan bakom dagens stora boom i artificiell intelligens är neurala nätverk, som blev möjligt att använda på grund av en stor utveckling i uträkningskraft med grafikkort. Neurala nätverk behöver astronomiska summor med uträkningAs deep neural networks grow more powerful, they also require more computational resources, which becomes a challenge when deploying on edge devices with limited computational capacity. This thesis looks into knowledge distillation, a model compression technique where a large "teacher" network transfers its learned features to a smaller "student" network. Our goal is to maintai

Animals communicate with a staggering diversity of rhythmic signals, yet behind all this diversity lies a small number of ethological mechanisms. In this chapter, we provide a quick review of how animal produce rhythmic signals based on these mechanisms, which span tremulation, percussion, bodily displays, stridulation, tymbalation, aerodynamic sound production (including vocalisation), as well as