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Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial toxin-antitoxin systems that pyrophosphorylate the 3'-CCA end of transfer RNA (tRNA) to prevent aminoacylation. toxSAS are implicated in antiphage immunity: Phage detection triggers the toxSAS activity to shut down viral production. We show that the toxSAS FaRel2 inspects the tRNA acceptor stem to specifical

Background. Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current treatments have increased overall survival but can lead to devastating side effects and late complications in survivors, emphasizing the need for new, improved targeted therapies that specifically eliminate tumor cells while sparing the normally developing brain. Methods. Here, we used a sonic he

Aims Previous studies on disparities in healthcare and outcomes have shown conflicting results. The aim of this study was to assess differences in baseline characteristics, management, and outcomes in myocardial infarction (MI) patients, by country of birth. Met hods a nd results In total, 194 259 MI patients (64% male, 15% foreign-born) from the nationwide SWEDEHEART (The Swedish Web-system for E

Following the record company Blue Note’s publicity campaign for jazz pianist Thelonious Monk in 1948, the image of Monk commonly presented in Swedish as well as American media was one of an eccentric, mysterious, even weird musician, sometimes viewed as a genius. This article presents and discusses the development of the Swedish media image of Monk during the period 1948–63, from the first mention

The purpose of this paper is to describe and analyse the establishment of large-scale food philanthropy in Sweden. Food philanthropy is here understood as collaborations between civil society organisations and the food industry, through which food surplus is turned into food aid for people in food insecurity. The first examples of such philanthropy emerged less than ten years ago in Sweden, but it

This thesis covers a set of methods related to machine perception and localization, which are two important building blocks of artificial intelligence. In Paper I, we explore the concept of regression via classification (RvC), which is often used for perception tasks where the target variable is either ordinal or when the distance metric of the target space is not well-suited as an objective funct

The ability to accurately estimate room impulse responses (RIRs) is integral to many applications of spatial audio processing. Regrettably, estimating the RIR using ambient signals, such as speech or music, remains a challenging problem due to, e.g., low signal-to-noise ratios, finite sample lengths, and poor spectral excitation. Commonly, in order to improve the conditioning of the estimation pro

In this work, we introduce a spatio-temporal kernel for Gaussian process (GP) regression-based sound field estimation. Notably, GPs have the attractive property that the sound field is a linear function of the measurements, allowing the field to be estimated efficiently from distributed microphone measurements. However, to ensure analytical tractability, most existing kernels for sound field estim

We have developed a tool, the MAGIC library, which provides an acidification assessment for any given lake or stream in Sweden based on ten parameters describing lake geographical position, surface area, annual discharge and observed lake water chemistry. The MAGIC library consists of two key components: a library of the existing MAGIC model simulations for 2438 lakes and an analogue matching rout

Objective: To assess (i) the impact of self-reported fatigue on functioning in daily life, and (ii) the association with sociodemographics, physical capacity, and work ability among people with post-COVID-19. Design: A cross-sectional study. Subjects: Adults reporting post-COVID-19 symptoms for at least 2 months. Methods: Participants were recruited through social media and responded to an online

This paper introduces P-expo, a do-it-yourself open-source software solution for enhancing online lectures. P-expo seamlessly integrates text, images, videos, webcams, and audio, with support for text-based tools like git for collaboration. Additionally, the paper introduces affordable DIY hardware components to enrich online education seminars, and presents a curated selection of accessible open-

LU-PZE is an interactive tool for illustrating fundamental concepts related to control theory, covering the relation between transfer functions, pole-zero plots, step responses, Bode plots, and Nyquist diagram. The tool gamifies education with dynamic assignments and quizzes. The tool is straightforward to use since it is web-based. https://lu-pze.github.io

Identification of preferential flow-paths, such as fractures, is required for various issues in geosciences. When chemicals are injected into the subsurface, monitoring the resulting structural and chemical changes remains a challenge. The ability of geophysical tomography to tackle this problem is not fully explored due to the lack of numerical methods suitable for modeling narrow structures. We

This study investigates the knowledge transfer from interdisciplinary research on Circular Economy (CE) to classical academic disciplines (ADs) such as Engineering, Economics, Geography, and Management. Despite the prolific publication of CE research in interdisciplinary journals, there is a notable discrepancy in its integration into traditional AD journals. Utilizing a bibliometric analysis of 2