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In persons born with myelomeningocele (MMC) secondaryprevention measures are important to survive and to retainfunction. Swedish guidelines in MMC have been developedand a follow-up programme is linked to a quality of care reg-istry, internet-based since 2012. The rationale for creation ofthis registry were to avoid complications in MMC by provid-ing a medical and health overview, facilitate the c
The hybrid combination of two-dimensional (2D) transition metal dichalcogenides (TMDs) and plasmonic materials open up novel means of (ultrafast) optoelectronic applications and manipulation of nanoscale light-matter interaction. However, control of the plasmonic excitations by TMDs themselves has not been investigated. Here, we show that the ultrathin 2D WSe2 crystallites permit nanoscale spatial
We study systems containing oppositely charged colloidal particles under applied alternating current electric fields (AC fields) using overdamped Langevin dynamics simulations in three dimensions. We obtain jammed bands perpendicular to the field direction under intermediate frequencies and lanes parallel with the field under low frequencies. These structures also depend upon the particle charges.
The recent discovery that metal nanoparticles can generate hot carriers upon light excitation is seen as a breakthrough in the fields of plasmonics and photonics. However, the high expectations for a plasmonic revolution in applications have been dampened by the ultrafast energy dissipation of surface plasmon polariton modes. While research aimed at suppressing loss mechanisms is still pursued, an
The electrochemical potential difference (Δμ¯) is the driving force for the transfer of a charged species from one phase to another in a redox reaction. In Li-ion batteries (LIBs), Δμ¯ values for both electrons and Li-ions play an important role in the charge-transfer kinetics at the electrode/electrolyte interfaces. Because of the lack of suitable measurement techniques, little is known about how
Growth approaches that limit the interface area between layers to nanoscale regions are emerging as a promising pathway to limit the interface defect formation due to mismatching lattice parameters or thermal expansion coefficient. Interfacial defect mitigation is of great interest in photovoltaics as it opens up more material combinations for use in devices. Herein, an overview of the vapor-liqui
The physical origin of sub-band gap photoluminescence in Ruddlesden-Poppers two-dimensional (2D) lead halide perovskites (LHPs) is still under debate. In this paper, we studied the photoluminescence features from two different facets of 2D LHP single crystals: the in-plane facet (IF) containing the 2D inorganic layers and the facet perpendicular to the 2D layers (PF). At the IF, the free carriers
Kolinfosfolipider, en nyttig kostkomponent vid alkoholfettlever, NAFLD och NASH?Åke Nilsson, Rui-Dong DuanBakgrundKolin (trimetyletanolamin) ingår i fosfatidylkolin (PC) och sfingomyelin (SM) som finns i alla cellmembraner och i plasmalipoproteiner, och i acetylkolin. Även om levern bildar en del kolin klassas kolin som ett essentiellt näringsämne. Kolinbrist ger bl a fettlever, muskelsymptom och
Motivated by the relevance of Pt clusters in heterogeneous catalysis, ordered Pt cluster superlattices are templated by the moiré of monolayer hexagonal boron nitride (h-BN) with Ir(111). Using X-ray photoelectron spectroscopy, scanning tunneling microscopy, and scanning tunneling spectroscopy, we provide a comprehensive picture for the mechanism of cluster binding, the thermal stability of cluste
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
Low-dimensional hybrid organic-inorganic metal halides have received increased attention because of their outstanding optical and electronic properties. However, the most studied hybrid compounds contain lead and have long-term stability issues, which must be addressed for their use in practical applications. Here, we report a new zero-dimensional hybrid organic-inorganic halide, RInBr4, featuring
Most mineral-Associated organic matter (MAOM) is protected against microbial attack, thereby contributing to longterm carbon storage in soils. However, the extent to which reactive compounds released by plants and microbes may destabilize MAOM and so enhance microbial access, as well as the underlying mechanisms, remain unclear. Here, we tested the ability of functionally distinct model exudates-l
This paper presents a joint experimental and numerical study on premixed laminar ammonia/methane/air flames, aiming to characterize the flame structures and NO formation and determine the laminar flame speed under different pressure, equivalence ratio, and ammonia fraction in the fuel. The experiments were carried out in a lab-scale pressurized vessel with a Bunsen burner installed with a concentr
Although current LC-MS technology permits scientists to efficiently screen clinical samples in translational research, e.g., steroids, biogenic amines, and even plasma or serum proteomes, in a daily routine, maintaining the balance between throughput and analytical depth is still a limiting factor. A typical approach to enhance the proteome depth is employing offline two-dimensional (2D) fractiona
Background: Patients with CHD exhibit reduced isometric muscle strength and muscle mass; however, little is known how these parameters relate. Therefore, the aim was to investigate the relation between isometric limb muscle strength and muscle mass for patients in comparison to age- and sex-matched control subjects. Methods: Seventy-four patients (35.6 ± 14.3 years, women n = 22) and 74 matched co
Three species of the family Teloschistaceae (lichenized Ascomycota) are described as new to science from Southern and Eastern Siberia and the Far East. Corticolous Caloplaca saviczii belongs to the genus Caloplaca s. str.; it has C. cerina-like apothecia and green to grey-green, crateriform soralia with a white rim. Lendemeriella aureopruinosa is a saxicolous taxon with a thin grey thallus and sma
We here present a comparison of methods for the pretreatment of a batch of tree rings for high-precision measurement of radiocarbon at the Aarhus AMS Centre (AARAMS), Aarhus University, Denmark. The aim was to develop an efficient and high-Throughput method able to pretreat ca. 50 samples at a time. We tested two methods for extracting α-cellulose from wood to find the most optimal for our use. On
Background: Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with Alzheimer's disease tau pathology. We compared the diagnostic value of both biomarkers in cognitively unimpaired participants and patients with a clinical diagnosis of mild cognitive impairment, Alzheimer's disease syndromes, or frontotemporal lobar degene
