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The receptor-like protein tyrosine phosphatase RPTPmu contains three intracellular domains: the juxtamembrane (JM) and two phosphatase domains (D1 and D2). D1 is catalytically active in vitro. The functional roles of JM and D2 are still unclear. To find out whether and how they modulate the phosphatase activity of D1, we compared the enzymatic characteristics of two constructs, containing a trunca
Estrogen ( ER) and progesterone receptor (PgR) status was analysed in paraffin-embedded breast cancer material with immunohistochemical (IHC) technique and compared with corresponding analyses in cytosols ( CYT). ER showed the same status (positive/negative) with both methods in 88% of the samples (352/ 402). The concordance was also high for PgR status (81% [321/394]). Besides values near cut-off
Objective: To examine whether smoking is a risk factor for rheumatoid nodules in early rheumatoid arthritis, and if so to determine the quantitative effect of smoking. Methods: From a cohort (n = 1589) in a structured programme for follow up of newly diagnosed cases of rheumatoid arthritis ( symptoms of swollen joints ( 12 months), 112 individuals with rheumatoid nodules at inclusion were identifi
The overall aim of this thesis was to investigate QoL and Health-Related QoL (HRQoL) among people aged 75 years and over in relation to socio-demographic variables, need of ADL help, various degrees of present QoL, self-rated health (SRH), health complaints, everyday activities, social support and sense of coherence (SOC). A further aim was to test a QoL scale and to illuminate older people's expe
BACKGROUND: Anti-neutrophil cytoplasmic antibodies (ANCA), originally found to be associated with vasculitis, have been reported to be present in chronic inflammatory bowel disease. Most often the ANCA staining pattern is of the perinuclear type (p-ANCA), although nuclear and cytoplasmic stainings are seen. Single studies have shown some of the antibodies to react with lactoferrin or cathepsin G;
Many phytoplankton species produce resting cysts, forming 'seed banks' on lake sediments until they germinate and provide inocula (recruitment) for future pelagic populations. We have addressed the question of whether the littoral or the profundal zone provides the inoculum for planktonic populations in a eutrophic and dimictic lake (Lake Erken, Sweden). Our hypotheses were that high temperature,
Popular Abstract in Swedish Denna avhandling presenterar data från två olika geografiska områden, Dronning Maud land, Antarktis, och den Skandinaviska fjällkedjan som befinner sig på den Baltiska kontinentalplattan. Dessutom presenteras en jämförande studie mellan två metoder att datera bergarter. Berggrunden i Dronning Maud Land domineras dels av migmatiserade bergarter, dels av post-tektoniska This thesis presents data from two areas, Dronning Maud Land, Antarctica, and the Scandinavian Caledonides, Baltica. In addition, a comparative geochronological study is presented. The bedrock of Dronning Maud Land (DML) is dominated by migmatitic gneisses and post-tectonic intrusions. A migmatitic gneiss at Jutulsessen nunataks, Gjelsvikfjella, has a protolith age of 1163 ± 6 Ma and a migmatisati
Context: Childhood ketotic hypoglycemia ( KH) is a disease characterized by fasting hypoglycemia and increased levels of ketone bodies. The cause is unknown. Objective: The objective of the study was to study a pair of homozygotic twin boys, one of whom had severe KH from the age of 14 months, whereas the other boy was apparently healthy. Design and Results: At the age of 6 yr, the boys were thoro
Calcium-sensitivity of contraction, force-velocity relation and ATP hydrolysis rate at different pH (6.2-7.8) were investigated in skinned smooth muscle preparations from the guinea pig taenia coli. Varied free-calcium levels were buffered by 4 mM BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid) which has calcium binding properties little affected by pH. A small increase of calcium
This article presents a study of the metaphor as instrument for the direct perception of events. Its major hypothesis refers to the event structure embedded in the ground of a metaphor. Since the ground is implicit in the linguistic manifestation, an invariant representation of textual movement patterns is assumed to capture the event structure. Experimentally, it is demonstrated that an event is
Abstract in Norwegian Leukotriener syntetiseres fra arakidonsyre. De er potente proinflammatoriske mediatorer og bidrar til hyperreaktivitet i luftveiene. Antileukotriener er en ny gruppe medikamenter ved astma, og Zafirlukast, en leukotrienreseptorantagonist, er nå registrert for behandling av mild til moderat astma i Irland og Finland. Vi har foretatt en litteraturstudie vedrørende antileukotriLeucotrienes are synthesized from arachidonic acid. They are potent proinflammatory mediators that contribute to bronchial hyperreactivity. Antileukotrienes constitute a new group of antiasthmatic drugs. Zafirlucast, a leukotriene receptor antagonist, is now registered in Ireland and Finland for the treatment of mild to moderate asthma. We have studied the literature on antileukotrienes and have f
Objective: Interstitial laser coagulation (ILC) of the prostate is a minimally invasive method for treating symptomatic benign prostatic enlargement (BPE). We performed a prospective randomized study to compare the clinical outcomes of ILC and transurethral resection of the prostate (TURP). Material and Methods: Between December 1997 and February 2000, 38 patients with moderate-to-severe symptomat
The possible teratogenic effect of erythromycin therapy, noted previously, was studied. Women who had taken erythromycin or penicillin V in early pregnancy and their infants were studied, using the Swedish Medical Birth Register where information on drug use during pregnancy was recorded based on interviews in early pregnancy. The risk for any congenital malformation after erythromycin therapy (bu
The form factor of A(o)(b) baryons is estimated using 3.46 x 10(6) hadronic Z decays collected by the DELPM experiment between 1992 and 1995. Charmed A(c)(+) baryons fully reconstructed in the pK(-)pi(+), pK(o)(s), and Api(+)pi(+)pi(-) modes, are associated to a c S lepton with opposite charge in order to select A(o)(b) --> A(c)(+)l(-)v(l) decays. From a combined likelihood and event rate fit to t
1. Strips from the follicle wall of bovine ovaries were incubated in Krebs-Ringer solution containing 3H-noradrenaline for measurement of transmitter liberation during electrical field stimulation (5 Hz frequency, 1 ms pulse duration, 10 V between the electrodes). The effects of noradrenaline as well as selective alpha-adrenoreceptor agonists and antagonists were studied on the electrically induce
