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Regulation and Function of the Human Leukotriene D4 Receptor CysLT1 in Epithelial Cells and Colon Cancer

Popular Abstract in Swedish Betændelses reaktionen er kroppens svar på en skade eller en infektion. Betændelses reaktionen gør at immunforsvarets celler kaldes til det skadede område (kan ses som den røde varme hævelse omkring et sår) og at eventuelle sygdomsfremkaldende emner identificeres og bekæmpes. På lidt længere sigt, fjernes ødelagt væv og helingen af såret påbegyndes. Når det skadede områThe pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. Since leukotrienes have been shown in increased concentrations in stools of IBD patients we hypothesise that LTD4 can play a role in the deve

Characterization of Secondary Metabolites from Natural Sources

Natural products have contributed for many years to the development of new medicines for the treatment of diseases. Their structural diversity and complexity have inspired chemists to produce interesting compounds with pharmaceutical use. Although many pharmaceutical companies have eliminated or scaled down their natural products research, they still remain an important source of new drugs. This

Experience of Policy Instruments for Energy Efficiency in Buildings in the Nordic Countries

The Nordic countries have often been seen as “fore-runners” of energy efficiency in buildings in terms of both 1) the implementation of policy instruments and 2) the evaluation of actual effects. Since the 1970s, the Nordic countries have introduced a range of policy instruments for energy conservation in buildings. Interestingly, there are contrasting policy “styles” and experiences across the No

Improved MALDI-TOF-MS analysis of partially depolymerised methyl cellulose by reducing end derivatisation

The depolymerized methyl cellulose was analyzed, using improved MALDI-TOF-MS by reducing the end derivatization. The methyl cellulose was depolymerized to give methylated oligo-(1->4)-β-D-anhydroglucoses (M-oligo-AG). To reduce the errors during measurement of degree of substitution (DS), M-oligo-AG was derivatized with Girard's T reagent performed on an equimolar mixture of maltooligosaccharides.

Från klarhet till klarhet. Lysande texter för sociologisk forskning

Samhällsvetenskaplig forskning äger vanligen rum ytterst stillsamt, bland högar av papper och böcker, vid datorskärmar och på seminarier. Men ibland händer det något. En dag kan man få tag i en text som hjälper en att skärpa blicken, få ordning på intrycken och energi nog att börja argumentera. Materialet faller på plats och forskningen går faktiskt framåt. Det handlar om teoretiska händelser –

On the Biosynthesis and Processing of Cathepsin G, Leukocyte Elastase, and Azurocidin ­ neutrophil granule members of a hematopoietic serine protease superfamily

Popular Abstract in Swedish Som skydd mot infektioner och andra omgivningshot har högre organismer utvecklat olika försvarssystem, där det mest betydelsefulla brukar sammanfattas under begreppet immunsystem. I detta ingår olika typer av specialiserade celler med ursprung i kroppens blodbildande organ, benmärgen. Den av immunsystemets olika celltyper som är viktigast för att skydda mot bakterieinfeThe serine proteases cathepsin G, leukocyte elastase, proteinase 3, and the inactive protease homologue azurocidin, stored in the azurophil granules of neutrophils, belong to a hematopoietic serine protease superfamily with members in mature effector cells of bone marrow origin. Promonocytic U-937 cells were used for studying the biosynthesis of cathepsin G and leukocyte elastase by biosynthetic r

Anthropogenic Open Land in Boreal Landscapes : Investigations into the Creation and Maintenance of Arable Fields on Swedish Farms

Popular AbstractJordbruksmarken representerar i det beskogade boreala landskapet en aktiv åtgärd som håller skogstillväxten borta. I avhandlingen undersöks lantbrukares praktiska beslutsfattande i samband med den öppna marken på gårdar som i Sverige ofta består av både jordbruks- och skogsmark. Som teoretiska ramverk används begreppen tidrum, landskap, orientering och åtagande för att förstå lantbThe human-induced open land (cropland, pasture) in the predominantly forested boreal landscapes relies on arable land use; it thus represents an active intervention to hold back forest regrowth. The thesis investigates the practical management decisions by landholders on discrete farms, which in Sweden often comprise both forest and arable lands. The theoretical framework utilizes the concepts tim

Optical characterization of tissue for medical diagnostics

Popular Abstract in Swedish Sammanfattning på svenska Denna doktorsavhandling beskriver några olika optiska metoder för diagnostik av biologisk vävnad. Målet har främst varit att utvärdera och förbättra dessa metoder för att kunna skilja mellan olika typer av cancertumörer, eller förstadier till sådana, och frisk vävnad. Om uppmätta data behandlas på ett lämpligt sätt kan man få information om väThis thesis deals with the development and evaluation of some different optical techniques for tissue characterization. The main aim has been to improve and evaluate such investigative techniques in in vivo studies. In this attempt a key issue has been to gain understanding in the underlying mechanisms of laser-based diagnostics of premalignant and malignant lesions and to evaluate methods