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Background: The authors have identified and studied a large kindred in which frontotemporal dementia (FTD) is inherited as an autosomal dominant trait. The trait has been mapped to the pericentromeric region of chromosome 3. Methods: The authors report on the clinical, neuroimaging, neuropsychological, and pathologic features in this unique pedigree collected during 17 years of study. Results: Twe
I allt fler länder börjar en brandteknisk klassificering av byggnadsdelar tillåtas som bygger på en analytisk behandling i stället för på resultat ac ugnsprovningar enligt ISO 834. I Sverige godtas sedan lång tid en analytisk branteknisk dimensionering av bärande och avskiljande konstruktioner som ett alternativ till standardiserad termisk påverkan enligt ISO 834. En väsentlig förutsättning för en
We study the geodesic exponential maps corresponding to Sobolev type right-invariant (weak) Riemannian metrics mu((k)) (k >= 0) on the Virasoro group Vir and show that for k >= 2, but not for k = 0, 1, each of them defines a smooth Frechet chart of the unital element e is an element of Vir. In particular, the geodesic exponential map corresponding to the Korteweg - de Vries (KdV) equation ( k = 0)
Popular Abstract in Swedish Rättvisekriterier och andra etiska aspekter spelar en stor roll i svensk sjukvård. De ingår t ex i målformuleringen i hälso- och sjukvårdslagen ("Målet för hälso- och sjukvården är en god hälsa och en vård på lika villkor för hela befolkningen.", §2). Läkare och andra beslutsfattare påpekar regelbundet vikten av moraliska värderingar, och befolkningen i gemen torde delaEquality of access may be defined and operationalised in several ways. Paper I, 'Equality of access. Definitions and policy implications', proposes a theoretical outline of possible definitions of equal access, of the policy measures needed to attain equality and of their consequences. The health economic literature proposes two main definitions of equal access. Equal access prevails either when i
We present a detailed analysis of time-resolved optical spectra of the ZZ Ceti white dwarf, HS 0507+0434B. Using the wavelength dependence of observed mode amplitudes, we deduce the spherical degree, , of the modes, most of which have . The presence of a large number of combination frequencies (linear sums or differences of the real modes) enabled us not only to test theoretical predictions but al
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Histological types of lung carcinoma were examined in a case series of workers exposed to asbestos cement dust (n = 29) and matched controls (n = 87). The proportion of adenocarcinomas was 31% among the exposed subjects and 15% among the controls (mid-p = 0.05). Among workers with high exposure the proportion of adenocarcinoma was even higher (45%, 5/11; mid-p = 0.03). The proportion of peripheral
In dealing with inexplicable disaster, like the untimely death of a child in a hospital, we increasingly turn to the justice system for accountability and retribution. While seemingly sensible, criminalizing human error has a range of negative consequences. But it does offer "good" narratives of failure as the result of human fault-even at the cost of guilt. Such narratives allow us to pinpoint a
Objective: Although the use of appropriate coping strategies has been suggested to be a key factor in determining successful adjustment to severe physical illness/disability, little systematic support for this link has been found. We investigated relationships between spinal cord lesion-related coping strategies and health-related quality of life when studying for sociodemographic, disability-rela
Many small passerines are resident in forests with very cold winters. Considering their size and the adverse conditions, this is a remarkable feat that requires optimal energy management in several respects, for example regulation of body fat reserves, food hoarding and night-time hypothermia. Besides their beneficial effect on survival, these behaviours also entail various costs. The scenario is
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin sensitivity is unknown. We therefore explored P-cell function and insulin sensitivity in Gcgr(-/
The genomic region containing the genes encoding the first leukotriene B(4) receptor, BLTR, as well as the recently cloned second leukotriene B(4)-activated receptor, BLTR2, was mapped by (a) sequence analysis of a human bacterial artificial chromosome (BAC) library containing a 15-kb segment corresponding to chromosome 14q11. 2-12 where the BLTR/BLTR2 genes were previously shown to be located, to
This study evaluated the early phase of development of a model for quality improvement of habilitation and rehabilitation project processes. The focus of the methodologic support in habilitation and rehabilitation model was on cooperation between practice contexts and science. Habermas' theory about communicative action was a theoretical frame of reference. Three project coordinators and ten proje
Nizar Qabbani (1923-1998) är en av den moderna arabiska poesins främsta förnyare. Han är för närvarande både den mest läste och den mest kontroversielle, den mest älskade och den mest hatade av samtidens poeter i Arabvärlden.
Glioblastoma multiforme (GBM) and other high-grade brain tumours are typically characterized by complex chromosome abnormalities and extensive intratumour cytogenetic heterogeneity. The mechanisms behind this diversity have been little explored. In this study, we analysed the pattern of chromosome segregation at mitosis in 20 brain tumours. We found an abnormal segregation of chromatids at mitosis
Various factors influencing affinity partitioning in aqueous polymer two-phase systems are studied by model calculations using a self-consistent mean-field lattice theory. The latter is an extension of the theory of Scheutjens and Fleer, adapted to take affinity ligand binding into account. The dependence of partition coefficients on ligand concentration is studied for different binding strengths,
