Background: Prognostic factors in patients with localized primary cutaneous malignant melanoma (CMM) are well described. However, prognostic factors for recurrence are less documented. Objectives: The aim of this study was to identify prognostic risk factors for first recurrence in patients with localized stages I-II CMM using population-based data. Methods: This study included 1437 CMM patients r

Global demand for transportation biofuels has increased significantly stimulated by policy interventions seeking GHG emission reductions, improved security of supply and rural development opportunities. However the impact on an increasing use of biofuels on land use and cover has become a global concern. While policy interventions have led to increased use of biofuels, certification is often regar

In the search for viable pathways for transforming governance and institutions in the Rio+20 agenda,strengthening of public‐private governance networks has been emphasized. Important initiatives arefound in the expanding bioenergy sector where several certification schemes have been launched forensuring that bioenergy feedstock meet environmental and social requirements. These initiatives areencou

Mutation rates for X-linked recessive diseases have so far been estimated indirectly by postulating an equilibrium between the loss of defective genes caused by the low reproductive fitness of affected males and the gain resulting from new mutations. Here, for the first time, we directly estimate both the overall and sex-specific mutation rates for haemophilia B by detecting the gene defect of the

BACKGROUND CONTEXT: Proper patient selection is of outmost importance in surgical treatment of degenerative disc disease (DDD) with chronic low back pain (CLBP). Among other factors gender was previously found to influence lumbar fusion surgery outcome.PURPOSE: This study investigates whether gender affects clinical outcome after lumbar fusion.STUDY DESIGN: National registry cohort study PATIENT S

Background: General Practitioners (GPs) are responsible for primary prescribing decisions in most settings. Elderly patients living in Advanced Care Facilities (ACFs) often have significant co-morbidities to consider when selecting an appropriate drug therapy. Careful assessment is required when considering appropriate medication use in frail older patients as they have multiple diseases and thus

Background. Exposure to allergens plays a role in the development of atopic sensitization and influences allergic phenotype. House dust mites (HDM) are a common source of aeroallergens in many parts of the world. The relationship between indoor environment factors such as temperature, moisture/humidity, and ventilation and HDM allergen load is complex. Methods. Part of a larger study into the heal