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Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. Objective: To examine GWG, adverse perinatal outcomes, substrate change

The core of this Doctoral thesis is mainly based in the studies of one-dimensional initial-boundary value problems, which are given by a single non-linear hyperbolic partial differential equation (PDE) with non-convex flux function, or by a system of strongly degenerate parabolic PDEs, for the simulation of sedimentation processes of solid particles immersed in a fluid. Particular attention is pai

Background. Type 2 diabetes (T2D) is a complex heterogeneous disorder affecting multiple organs. Gene expression studies in organs central to T2D, such as pancreatic islets and skeletal muscle will help elucidate and disentangle molecular mechanisms underlying T2D. Deep phenotyping using commonly measured clinical variables allows for the identification of clinically relevant T2D subgroups, repres

Background: Concurrent chemoradiotherapy is standard treatment for limited stage small-cell lung cancer (SCLC). Twice-daily thoracic radiotherapy of 45 Gy in 30 fractions is considered to be the most effective schedule. The aim of this study was to investigate whether high-dose, twice-daily thoracic radiotherapy of 60 Gy in 40 fractions improves survival. Methods: This open-label, randomised, phas

Unicellular photosynthetic golden algae called diatoms are one of the most abundant silicifying organisms. Diatoms take up silicon and build their frustules, in the form of biogenic silica (BSi), which have high preservation potential, and thus are found in sediments. Around 27 % of the annual dissolved silicon (DSi) delivery from the land to the ocean is retained in lakes and reservoirs in the fo

Kraft black liquor (KBL) is a side-stream that is produced during the kraft pulping process, and mainly contains lignin, hemicelluloses, and cooking chemicals, namely sodium hydroxide and sodium sulphide. KBL is usually evaporated and burned in a recovery boiler in order to recover the cooking chemicals and generate energy. However, pulp mills are sometimes limited by the capacity of their recover

In the field of operations and supply chain management (OSCM), the customer order decoupling point (CODP) hasi been recognized as an important strategic parameter for roughly 30 years. It is the point in the value chain where forecast-driven material flows get separated from order -driven material flows. Despite its long history in the field, multiple calls for further consideration of the CODP inIn the field of operations and supply chain management (OSCM), the customer order decoupling point (CODP) hasbeen recognized as an important strategic parameter for roughly 30 years. It is the point in the value chain whereforecast-driven material flows get separated from order-driven material flows. Despite its long history in the field,multiple calls for further consideration of the CODP in OSCM

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the subclassification of ANCA-associated vasculitis is subject to continued debate. Here we aim to identify phenotypically distinct subgroups and develop a da

Dual-mobility cups in THA were designed to reduce prosthesis instability and the subsequent risk of revision surgery in high-risk patients, such as those with hip fractures. However, there are limited data from clinical studies reporting a revision benefit of dual-mobility over conventional THA. Collaboration between anthroplasty registries provides an opportunity to describe international practic

The intestinal flora and the bacteria found in the extraintestinal sites were studied in liver injury rats, with or without Lactobacillus plantarum 299v pre-treatment. The dominating intestinal flora and translocating bacteria were typed by RAPD and identified by 16S rDNA sequencing. It was proved that bacterial strains from the intestine could pass through the intestinal barrier to the extraintes

SummarySustainable sewage sludge management has been a heavily debated topic in Europe for more than a decade. Due to its content of pollutants such as heavy metals, pharmaceuticals and other organic micropollutants, the use of sewage sludge for farmland application is currently banned or restricted in most European countries. Therefore, alternative methods for sludge management are discussed. The

Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. The pancreatic beta-cell is controlled by ion channels. Voltage-gated

I samband med äktenskapsskillnad kan frågan om nyttjanderättsersättning aktualiseras om en av makarna tillsvidare bor kvar i en tidigare gemensam bostad. Då det i svensk rätt saknas lagstadgande om nyttjanderättsersättning syftar denna framställning till att klargöra rättsläget, genom att analysera framförallt praxis och doktrin. Avslutningsvis syftar framställningen till att diskutera om tillämpn

Bröstcancer är vanligt förekommande bland kvinnor, en av tio kvinnor får en bröstcancerdiagnos under sin livstid. Upplevelsen av bröstcancer är en komplex process, som innebär ett flertal sammanlänkade stressfulla händelser. Det är därför tydligt att sättet personen reagerar på sådana stressorer kan ha en betydande påverkan på både fysisk och psykisk hälsa. Resiliens är ett konstrukt som innefattaBreast cancer is a common event among women, one in ten women receiving a breast cancer diagnosis in their lifetime. The experience of breast cancer is a complex process that entails a multitude of interlinked potentially highly stressful events. It is thus evident that the manner in which one reacts to such stressors can have a substantial impact on both physical and mental health. Resilience is

Aims/hypothesis: Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, we assessed sex-specific associations between the validated proteins and pathophysiological pathways of type 2 diabetes. Methods: This cross-sectional study included Black So

Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. These are glucose-and lipo-toxicity, ER stress, pro-inflammatory cytokines, dysfunctio

Climate changes, tightly linked to anthropogenic activities, are significantly altering environments and ecosystems globally, such as by increasing marine and coastal deoxygenation or occurrences of extreme weather events. The significance of paleoenvironmental and -climate reconstructions, as well as monitoring of current conditions, for unravelling baseline natural variation, today’s changes and

Fear of falling (FOF) is common in persons with Parkinson’s disease (PD) and may have large consequences in daily life, causing a sedentary lifestyle, social isolation and reduced quality of life. FOF is therefore an important aspect to consider for researchers as well as clinicians and the rehabilitation team. Adequate and high quality rating scales are needed to be able to accurately assess FOF

Målet med detta projekt var att studera hur tre församlingar i tre kyrkliga miljöer – Odarslövskyrka (Torns församling), Ignaberga nya kyrka (Hässleholms församling), och Östra Nöbbelövs kyrka (Simrishamns församling) i Lunds stift – skulle kunna utveckla sina kyrkliga miljöer för egen del och i samverkan för att öka tillgängligheten till de kyrkliga miljöerna och utveckla dem till meningsfulla anThe objective of this project was to study how three congregations/parishes in three church environments – Odarslövs kyrka (Torn’s parish), Ignaberga nya kyrka (Hässleholm’s parish), and Östra Nöbbelövs kyrka (Simrishamn’s parish) in the Diocese of Lund – could develop the church environments under their auspices in order to increase their accessibility and forms of meaningful use for members of t