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Background: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer. Methods: We applied a recently described five-strata model, the Cambridge Prognostic Groups (CPGs 1-5), in two international cohorts and tested prognostic performance against the curren

Jordens plattektoniska rörelser leder till tektoniska skeenden vid plattgränserna, bland annat bergskedjebildning, då berggrunden utsätts för förändringar i tryck och temperatur. Vid ändrat tryck och ändrad temperatur förändras också bergarter: de ursprungliga mineralen konsumeras i kemiska reaktioner och i stället bildas nya mineral som är stabila vid de nya fysikaliska förhållandena - en processDating of metamorphic events is crucial for the understanding and reconstruction of large-scale geological processes such as orogenesis. Zircon is one of the most commonly used minerals for dating of igneous and metamorphic events. Zircon incorporates uranium and excludes lead during crystallization, and with time the uranium decays to lead. The diffusion rates of both elements are slow, making zi

Flyktingar, speciellt de som varit utsatta för tortyr och annan form av organiserat våld, upplever ofta en rad olika svårigheter, inklusive posttraumatiskt stressyndrom (PTSD), depression och somatiska symtom, särskilt smärta. Multidisciplinär behandling har utvecklats för att handskas med denna komorbiditet hos flyktingar, som har påvisat medelhöga effekter.Det huvudsakliga syftet med denna avhanRefugees, particularly those exposed to torture and other forms of organized violence, often experience a wide range of difficulties, including posttraumatic stress disorder (PTSD), depression, and somatic disturbances, particularly pain. Multimodal treatments have been developed to target this comorbidity in refugees, with evidence suggesting they are moderately effective.The overall aim of this

Although literature concerning chronic pain patients indicates that cognitive behavioural variables, specifically acceptance and fear of movement/(re)injury, are related to life impact, the relative roles of these factors in relation to pain characteristics (e.g. intensity and spreading) and emotional distress are unclear. Moreover, how these variables affect rehabilitation outcomes in different s

Importance To our knowledge, there is no consensus regarding when individuals who repeatedly self-harm and are at risk of suicide should be hospitalized. To evaluate a new alternative, we examined the effects of brief admission (BA) to hospital by self-referral.Objectives To determine the effects of BA on inpatient service use and on secondary outcomes of daily life functioning, nonsuicidal self-i

BACKGROUND: The New Public Management movement strove for transparency so that policy makers and citizens could gain insight into the work and performance of health care. As the use of the electronic health record (EHR) started to diffuse, a foundation was laid for enhanced transparency within and between health care organizations. Now we appear to be experiencing a new kind of transparency in the

Temperaturändringar och krympning påverkar betongkonstruktioners volym, och i konstruktioner som hindras från av röra sig kan sådana volymändringar leda till så kallade tvångseffekter, som i sin tur kan orsaka sprickbildning. När detta sker kan emellertid konstruktionen deformeras till viss del, vilket gör att tvångsspänningarna och därmed också sprickvidderna minskar. Uppsprickningsförloppet är sThermal actions and shrinkage cause volume changes in concrete structures. In structures which are restrained from movements, the restraint effects can cause cracking. However, when cracking occurs, the structure can deform to some extent, which reduces the restraint stresses and thus also the crack widths. As the exact crack development is hard to predict beforehand, the actual restraint and thus

Objectives: The correlation between subjective and objective outcomes of nasal obstruction is still a matter of controversy. The aim of this study was to determine the minimal level of side difference in nasal airway resistance (NAR measured by Broms' v2) between the two nasal cavities, which could be discerned subjectively by the patient on a visual analogue scale (VAS). Nasal airway resistance w

The rugged field and group of trees between housing estates or next to the railroad tracks, the left-over space of deserted industrial areas, the vacant demolition site of a central city block – they could all be termed ‘urban voids’. However, they are often anything but voids, in a literal sense, as they are not empty, or deserted. Yet they are ‘urban voids’, lacking an evident function, or a def

Thisthesis revisits and explores the relationship between verse and meaning bymeans of the notion of iconicity, i.e.,as signs primarily based on similarity. The aim of the thesis is to show howverse and its interaction with words and sentences create meaning and can be anintegrated part in the interpretation or understanding of the poem as a whole.Verse is discussed in relation to four other liter

Politisk komedi är en hybridgenre där politiska nyheter och analyser blandas med komedi och underhållning. Allt eftersom politisk komedi ökar i popularitet – i de flesta medieformer och nationella kontexter – arbetar forskare med att förstå dess roll i relation till medborgarskap, och det kan konstateras att genren utmanar den vetenskapliga förståelsen av politiska medier och medborgarskap. Denna Political comedy is a hybrid genre that mixes political news and analysis with comedy and entertainment. As it becomes more and more popular in most media forms and national contexts, researchers struggle to understand its role in relation to other types of political media, and of citizenship; in this sense, it challenges scholarly conceptualisation of political media and citizenship. Thus, this t

Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. Objective: To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) an

Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti

BackgroundPathogenic germline variants (PGVs) in certain genes are linked to higher lifetime risk of developing breast cancer and can influence preventive surgery decisions and therapy choices. Public health programs offer genetic screening based on criteria designed to assess personal risk and identify individuals more likely to carry PGVs, dividing patients into screened and non-screened groups.

BACKGROUND: Osteoarthritis is a leading cause of disability worldwide. Current treatment supports coping strategies to improve health-related quality of life (HRQoL). The need to predict response to treatment has been raised to personalise care. This study aims to examine change in HRQoL from baseline to three and nine months follow-up after participating in a Supported Osteoarthritis Self-Managem

Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was

Background: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We aimed to assess whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents aged 10−18 yea

Background: Speech impairments are an early feature of Alzheimer’s disease (AD) and consequently, analysing speech performance is a promising new digital biomarker for AD screening. Future clinical AD trials on disease modifying drugs will require a shift to very early identification of individuals at risk of dementia. Hence, digital markers of language and speech may offer a method for screening

Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p

BACKGROUND: Exposure to adverse childhood experiences (ACE) have been found to have profound negative consequences on an individuals' health. Non-suicidal self-injury (NSSI) is a clinically complex and serious global health issue and is closely related to suicide attempts. Previous research has found associations between ACE and NSSI and suicide attempts in clinical samples. However, this associat