Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated the therapeutic potential of MCC950, a specific, small-molecule inhibitor of

I Sverige kommer ungefär 2-3 % av befolkningen någon gång att drabbas av paniksyndrom med eller utan agorafobi (PS/A), ett tillstånd som består av plötsliga, oväntade panikattacker som följs av ihållande rädsla för nya attacker och/eller betydande livsstilsförändringar. PS/A debuterar oftast i slutet av tonåren eller i tidig vuxenålder och ger om den förblir obehandlad ofta kroniska psykiska besvä

To achieve significant improvements, there is a need for a systematic approach in Road Safety Management. The first step of such approach is to define the burden of road casualties in the country. Part of defining the burden is the monetary valuation of the prevention of a fatality accident. Such “values of statistical life” are derived in a number of countries, however, there is a large variation

En betydande del av Europas byggnadsbestånd behöver renoveras. De vanligaste anledningarna till att man genomför renoveringar är akuta tekniska problem eller en byggnads eller dess komponenters utgående livslängd. Andra vanliga skäl för byggherrar att genomföra renoveringar i sitt byggnadsbestånd är höga kostnader för underhåll och drift samt ett högt energibehov. Dessutom har bygg- och fastighetsA considerable amount of Europe’s building stock needs to be renovated. The most common reasons for carrying out renovations are acute technical issues or the expiring life span of a building or its components. Other common reason for building owners to carry out renovations in their building stock are high costs for maintenance and operation, and a high energy demand. Furthermore, the constructio

Faryngotonsillit, eller halsfluss, är en vanlig orsak till att patienter söker primär-vård och är även en vanlig orsak till antibiotikaförskrivning. Bakterien Grupp A-streptokocker (GAS) har sedan länge varit den viktigaste mikroorganismen vid halsfluss, inte minst på grund av dess koppling till följdsjukdomar som exempelvis reumatisk hjärtsjukdom, men det finns många andra bakterier och virus somPharyngotonsillitis, or acute sore throat, is a common reason for attending primary health care and a common reason for antibiotic prescription. Group A Streptococcus (GAS) has long been considered the most important pathogen in pharyngotonsillitis, but a wide array of other bacteria and viruses have also been associated with this condition. However, few studies have used modern approaches for aet

Combustion of fossil diesel is a major environmental problem for both the climate and human health. Renewable diesel fuels have been developed and introduced to the market to reduce the net CO2 emissions. Emission control strategies, such as aftertreatment systems, have been implemented to reduce the health hazardous particulate matter (PM) and nitrogen oxides (NOx) emissions. The overall aim of t

Negative health effects of exposure to particles of outdoor origin have been confirmed by epidemiological studies. In developed countries, we spend on average 65% of our time in our homes. Thus, the properties of airborne particles indoors need to be understood. The aim of this PhD thesis was to investigate the differences in physicochemical and toxicological characteristics of fine particles (PM2.5

The Covid-19 pandemic has fundamentally changed travel patterns to and in major urban regions. Destinations have seen a dramatic shift from overtourism to undertourism. This has led to new challenges for regional destination management organisations (DMOs) as tourists and residents seek green areas in cities and visit adjacent natural reserves. Therefore this research explores how the Covid-19 pan

Besvär från rörelseorganen, framför allt från rygg och nacke är en av de vanligaste anledningarna till sjukfrånvaro i västvärlden. Patienter med dessa besvär utgör en stor andel av de som söker primärvården där fysioterapi ofta är första linjens vård. Rygg och nacksmärta kan orsaka nedsatt funktion och aktivitetsförmåga vilket ofta innebär en betydande förlust av livskvaliteten samt ekonomiska konPatients with back and neck pain are frequently seen in primary care, where they are directed to physiotherapy as first-line treatment. The condition affects both the individual, by causing pain and disability, and society, because of high costs caused by work disability and health care consumption. Clinicians need tools to identify, at an early stage, patients at risk of poor outcome, in order to

My research engages with the varieties of relationship between verbal and non-verbal forms of language and communication. I approach the issue through three people who live or work with non-verbal people on the autistic spectrum: Phoebe Caldwell, Fernand Deligny and Iris Johansson. Their practices bring singular perspectives to my core question: How can we (re)conceive and engage with non-verbal f

Aim/hypothesis: Human enteroviral infections are suggested to be associated with type 1 diabetes. However, the mechanism by which enteroviruses can trigger disease remains unknown. The present study aims to investigate the impact of enterovirus on autophagy, a cellular process that regulates beta cell homeostasis, using the clonal beta cell line INS(832/13) and human islet cells as in vitro models

Representing an international, multi-institutional research team, the panel presents a theoretical framework for understanding what prompts academic staff/faculty to change towards sustained use of pedagogies that make a meaningful difference in student learning. The theory grows out of a synthesis of literature on: the role of leadership and resources in emerging changes to teaching practices (Gi

The district heating sector in Sweden is today facing several challenges due to competition from other heating alternativesas well as decreasing heat demand in buildings. To increase its competitiveness, the district heating companieshave to find ways to keep their production costs at a more or less constant level. One way of doing this is to increasethe efficiency of the district heating systems.

What can we learn by transmitting electrical currents through electrodes in the ground? Geophysical methods can help us to locate the bedrock, valuable mineral ores, remains of ancient buildings and many other secrets hiding below the surface. However, it is not only the universal interest for the unknown that drives the geophysical research forward. Knowledge of, for example, fractured bedrock, c

Diabetes is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular complications) as well as microvascular disorders leading to damage of the small vessels and the development of retinopathy, nephropathy and neuropathy. The underlying pathogenesis is not clear, but hyperglycemia has been identified as an important risk factor. Previous work fro

Vad står vi på – hur tar man reda på det? Kanske man kan titta på en geologisk karta, borra ett hål eller gräva en grop? Det kan gå bra, men ibland finns det inte tillräckligt detaljerade kartor och att gräva upp allt man är intresserad av är ingen lysande idé. Tänk om man kunde forska fram en metod som gör att man kan se rakt igenom marken, som röntgenundersökningar på sjukhus! På sätt och vis kaWhat would you find below your feet – how do you find out? Perhaps you could look at a geological map, drill, or dig? That could work, but sometimes the maps are not detailed enough, and digging everywhere to find out is impractical. Imagine if you could develop a method that allows you to see straight through the ground, as x–rays through the body! To some extent, such methods already exist; you

Older people with arrhythmias comprise a large group requiring complex care, posing many healthcare challenges. Rapid growth of the older population demands a better understanding of the needs of this patient group. The aim of this thesis was to investigate arrhythmia prevalence, incidence, survival, and experiences from the perspective of a geriatric population (aged 60+ years), and to examine th

Kapitalförsäkringar är idag en schablonbeskattad sparform. Tillgångar som innehas på en kapitalförsäkring som ges ut av ett svenskt livförsäkringsbolag ägs av och beskattas hos försäkringsbolaget. Försäkringstagaren, som antingen kan vara en fysisk eller en juridisk person, debiteras löpande för tillgångarna i försäkringen genom att en schablonberäknad intäkt beskattas med avkastningsskatt. En ann

Since the demand on ready-to-eat (RTE) and raw, minimally processed products is high and increasing in today´s market, the microbial quality is important. One of these products is RTE salads and salads mixes that are bagged and since it is supposed to be eaten raw without any step to reduce the microbial load, these types of products are considered to be risk foods and that the risk of foodborne oThe all year around available ready-to-eat salad are increasing in popularity, and parallel with this, vegetable-derived foodborne illness outbreaks as well. Can a too long shelf life for these products be part of the problem? During recent years the focus on healthy diets and lifestyles has increased. Vegetables and fruits are important to include in meals and are a part in many modern health die