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INTRODUCTION: Elevated levels of markers for thrombin activation are associated with plaque echogenicity and degree of stenosis in patients with carotid artery stenosis. The Activated Protein C-Protein C Inhibitor (APC-PCI) complex reflects activation of the Protein C system and is a measure of thrombin generation. The aim of the present study was to examine APC-PCI complex in patients undergoing
AIMS/HYPOTHESIS: The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. METHODS: A cohort of 24,799
Background Chronic immune stimulation appears to be associated with lymphoplasmacytic lymphoma (LPL)-Waldenström macroglobulinemia (WM); however, available information is sparse. We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM. Me
Background: Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large r
BackgroundMolecular subtypes of lung adenocarcinoma (LUAD) with varying prognosis and characteristics have been proposed based on one or two-dimensional studies but are not yet implemented into clinical routine. Epigenetic modifications in cancer cells are independent of sequence variants, directly linked to gene and genome regulation, and thus provide important information to guide subclassificat
BackgroundChronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are characterized by persistent airway inflammation and airflow limitation. Measuring airway inflammation may be of value both in research and clinical practice. Calprotectin, a protein associated with neutrophil activation, serves as a potential biomarker for airway inflammation. This study evaluates the performance o
BACKGROUND: Ageing is associated with circadian rhythm sleep disorders, poor sleep at night, less physical activity and more time spent indoors, affecting the wellbeing of older adults. Their sleep and mood could benefit from daytime outdoor physical activity, exposure to daylight, better indoor lighting and sleep routines. However, changes to routines can be challenging depending on individual be
Background: Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. Methods: We harmonized individual-level data from 2,078,948 participants across 133 cohorts, 39 countries, and 6 continents. Lifetime risk of car
BackgroundPrimary care is key to early identification and referral of patients with Alzheimer’s disease (AD). Assessing eligibility for new anti-amyloid treatment may guide appropriate referrals and prevent overburdening specialized care. In this study we determined eligibility for anti-amyloid treatment in patients undergoing cognitive evaluation in primary care.MethodPatients were selected from
Background: Procalcitonin (PCT) is a biomarker used to differentiate between viral and bacterial infections, though the underlying mechanisms are not yet fully understood. This study aimed to identify genetic variants associated with plasma PCT concentrations and explore the associations of genetically predicted PCT with a wide range of disease related traits in a PheWAS. Methods: We conducted GWA
Background: The need for complete staging surgery including hysterectomy for all age patients with borderline ovarian tumors (BOT) is debatable, considering fertility in younger patients and potential higher morbidity in older patients. We aimed to investigate the relapse risk and overall survival in a cohort including patients who underwent conservative surgery (organ-preserving procedures) to miBackground:The need for complete staging surgery including hysterectomy for all age patients with borderline ovarian tumors (BOT) is debatable, considering fertility in younger patients and potential higher morbidity in older patients. We aimed to investigate the relapse risk and overall survival in a cohort including patients who underwent conservative surgery (organ-preserving procedures) to min
Antibiotic resistance poses a global threat. Antibiotics are administered to 80-90% of terminally ill patients but evidence of their effectiveness in improving survival or symptom relief at the end of life (EOL) is scarce. To determine the proportion of deceased patients that continue antibiotic treatment after documented EOL discussion and the decision to prioritise symptom relief over active tre
ObjectivesAutoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.MethodsIncluded were 13,860 HLA-DQ-genotyped children at birth and previously invited to a screen
Importance The clinical utility of the comprehensive laboratory and medical investigations currently recommended for children with pediatric acute-onset neuropsychiatric syndrome (PANS) remains unclear. Notably, comparisons with relevant psychiatric control patients without suspected immunologic pathogenesis are lacking. Objective To evaluate whether currently recommended laboratory investigations
Background: This study evaluates deep learning (DL) using gene expression (GEX) and preoperatively available clinical data (PreopClinic) to predict sentinel lymph node macro-metastasis (SLNM), and explores their potential for guiding axillary surgery de-escalation and supporting prognostic assessment.Methods: We retrospectively included 6,836 clinically node-negative (cN0) T1-T2 patients with inva
Introduction: The contribution of aortopulmonary collateral (APC) flow to pleural effusion (PE) after total cavopulmonary connection (TCPC) remains unclear. Excessive APC flow may alter mesenteric perfusion and increase ventricular volume load. We evaluated echocardiographic and mesenteric flow parameters as predictors of PE duration and their association with magnetic resonance imaging (MRI)-deri
Östersjön har stora problem med övergödning, eutrofiering, vilket beror på en ökad transport av näringsämnen från omgivande länder. Näringen kommer främst i form av kväve och fosfor från jordbruket och transporteras ut i Östersjön via floder. Framförallt kväve har stor påverkan på övergödningen, som i sin tur leder till fiskdöd, algblomning och syrefria bottnar i sjöar. I den här studien ska läckEutrophication problems in the Baltic Sea have drawn attention to the contribution of nutrients from surrounding countries. The problems have attracted considerable attention to non-point source nitrogen pollution of rivers and lakes. The ability to predict nitrogen export from inland sources is essential in order to evaluate the effects of anthropogenic activities, of which the leakage from agric
SARS [Severe Acute Respiratory Syndrome] penetrated China in spring of 2003, created havoc in the social society, exposed weaknesses within the political system and pushed the nation towards a crisis of confidence. At the same time the crisis revitalised the Party's position, brought people from different social stratum together and had a beneficial impact on the populace's knowledge on he
