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Objective: To evaluate whether the duration of the active phase of labor is associated with maternal body mass index (BMI), in nulliparous women with spontaneous onset of labor. Study design: Historical prospective cohort study including 63,829 nulliparous women with a singleton pregnancy and a spontaneous onset of labor, who delivered between January 1, 1995 and December 31, 2009. Data were colle
To compare the efficacy and safety of weekly albiglutide with daily sitagliptin, daily glimepiride, and placebo.RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes receiving metformin were randomized to albiglutide (30 mg), sitagliptin (100 mg), glimepiride (2 mg), or placebo. Blinded dose titration for albiglutide (to 50 mg) and glimepiride (to 4 mg) was based on predefined hyperglycemia c
Genetic and epigenetic mechanisms may interact and together affect biological processes and disease development. However, most previous studies have investigated genetic and epigenetic mechanisms independently, and studies examining their interactions throughout the human genome are lacking. To identify genetic loci that interact with the epigenome, we performed the first genome-wide DNA methylati
Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinati
It is presently unclear whether free serum 25 hydroxyvitamin D (S 25(OH)D) better reflects bone health than total S 25(OH)D. We have previously shown that summer total S 25(OH)D values are more useful to predict bone mineral density (BMD) than winter values. Our objective was therefore to compare the relative importance of free and total S 25(OH)D for BMD by season. BMD was measured by dual energy
Introduction: The physical activity health paradox refers to the contrasting associations of leisure-time physical activity and occupational physical activity with cardiovascular disease, but whether this applies to Type 2 diabetes risk is unknown. This study aimed to investigate the physical activity health paradox and age-specific Type 2 diabetes. Methods: Working adults (N=5,866) in Denmark age
Introduction: Amphetamine use is an increasing problem, and studies suggest a connection between amphetamine use and cardiovascular and cerebrovascular pathology. However, few long-term studies examine amphetamine users' risk of cardiovascular and cerebrovascular pathology, in comparison to users of other drugs. In addition, in a criminal justice system, illicit drug use and psychiatric comorbidit
The increased prevalence of individuals with Autism Spectrum Disorders (ASD) challenges society to evaluate the quality and efficacy of community based psycho-pedagogical programmes in order to achieve progress and to attain an acceptable level of quality of life for its citizens. The overarching aim of this thesis was to gain knowledge about staff’s pedagogical work and to provide a method for as
Aims: We tested whether autoantibodies to all three ZnT8RWQ variants, GAD65, insulinoma-associated protein 2 (IA-2), insulin and autoantibodies to islet cell cytoplasm (ICA) in combination with human leukocyte antigen (HLA) would improve the diagnostic sensitivity of childhood type 1 diabetes by detecting the children who otherwise would have been autoantibody-negative. Methods: A total of 686 pat
Reconstructions of palaeomagnetic secular variation (PSV) in sediment cores can be compared to well-dated regional PSV master curves to infer deposition age. The existing PSV master curve for Fennoscandia, "Fennostack" (Snowball et al., 2007), is limited to the past 10 ka. In this study, we construct a deglacial (for the interval 14-11 ka) PSV master curve for Fennoscandia by including data from a
AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev
This thesis examines whether host-country geopolitical risk leads foreign subsidiaries of multinational enterprises (MNEs) to hold higher levels of cash. While the precautionary motive predicts that firms accumulate liquid reserves when uncertainty rises, the MNE setting introduces a competing force: parents can reallocate liquidity across affiliates through internal capital markets, and agency co
INTRODUCTION: Central venous catheters (CVCs) are essential in modern healthcare. Insertion of a CVC promotes a hypercoagulable environment, in part through activation of the intrinsic coagulation pathway. We have previously shown that blood obtained from newly inserted CVCs demonstrates immediate coagulation activation, with differences between samples collected directly after insertion and after
Locknekratern i Jämtland, centrala Sverige bildades för cirka 455 miljoner år sedan i ett grunt epicontinentalt hav när en meteorit med en diameter på 600 meter slog ner i den Baltiska skölden. Nedslaget skapade en 7.5 km bred inre krater i det proterozoiska kristallina urberget som överlagrades av skiffer och kalksten. Eftersom den ursprungliga morfologin hos nedslagskratrar snabbt eroderas på jo
The Copernicus High Resolution Vegetation Phenology and Productivity product (HR-VPP) has been operational for several years and has been used by various institutions to assess crop growth conditions and estimate crop yield. However, studies focusing on winter-growing crops, especially winter wheat, remain limited. HR-VPP is based on the Plant Phenology Index (PPI). In theory, PPI is expected to p
This licentiate thesis builds on an interest in scholarly communication and social networks within in library and information science, in particular in the area of information seeking and use. The specific purpose is to create a scientifically founded understanding of how the interaction of caring scientists in social networks contributes to the scientists sense-making in their research practice.
