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Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes treatment approaches challenging to personalize. A recent Scandinavian study proposed a novel classification of adult diabetes into five clusters based on disease pathophysiology and

Purpose: Twenty-first century crises reaffirm the need of faster mobilization of resources during crises. Without interorganizational collaboration and resource mobilization, organizing efficient response is not possible. Resource mobilization is an essential aspect of response. It ensures a faster and better response. Collaboration between teams of emergency responders may include commonly known

Femoroacetabular impingement (FAI) syndrome is often treated with hip arthroscopy (HA) with the goal of enabling return to sport. While the number of HAs has been rising, little is known about the rehabilitation process or about outcomes related to return to sport (RTS) following the procedure. The overarching aim of this thesis wasto describe the rehabilitation process following HA in Scandinavia

Background and Purpose: Clinicians will increasingly encounter adult patients who were born preterm and will need to understand their long-term sequelae. Adult survivors of preterm birth have been reported to have increased risks of hypertension and other stroke risk factors. However, their stroke risks have seldom been examined and the findings are discrepant, possibly due to small sample sizes,

Spy scandals in Western democracies can be seen as a power battle between three actors: investigative journalists, whistleblowers and the intelligence organizations at the center of the scandal. It is a conflict played out both within and outside of the court-house as the actors try to claim the label “hero” for themselves while actively trying to repudiate other labels, such as “traitor”, “spy” o

Small birds are hot creatures with an average body temperature of 40° Centigrade, and so must burn energy at a formidable rate to stay warm. This becomes quite the challenge in winter when birds are 40-50 degrees warmer than outside for extended periods, even in comparatively mild regions such as Scotland. Thus, the little bird in winter must spend most of the day either feeding or searching for

Background: The risk to develop memory impairment in has been widely investigated in type 2 diabetes (T2D). There are several mechanisms proposed for T2D-associated cognitive impairment, such as brain insulin resistance, synaptic dysfunction, inflammation, gliosis, or disruption of neuron-astrocyte interactions (Garcia-Serrano & Duarte, 2020). On the other hand, supplementation with the antiox

Background: Evolutionary processes can cause strong spatial genetic signatures, such as local loss of genetic diversity, or conflicting histories from mitochondrial versus nuclear markers. Investigating these genetic patterns is important, as they may reveal obscured processes and players. The maternally inherited bacterium Wolbachia is among the most widespread symbionts in insects. Wolbachia typ

Background: Radical prostatectomy reduces mortality among patients with localised prostate cancer. Evidence on whether different surgical techniques can affect mortality rates is lacking. Objective: To evaluate functional and oncological outcomes 8 yr after robot-assisted laparoscopic prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Design, setting, and participants: We enroll

The prognostic importance of tumor-specific nuclear insulin receptor (InsR) expression in breast cancer is unclear, while membrane and cytoplasmic localization of InsR is better characterized. The insulin signaling network is influenced by obesity and may interact with the estrogen receptor a (ERα) signaling. The purpose was to investigate the interplay between nuclear InsR, ER, body mass index (B

Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glyca

Den första januari 2012 sänkte den då sittande alliansregeringen momssatsen för restaurang- och cateringtjänster från 25 % till 12 %. Det övergripande målet med den lägre momssatsen är att stimulera efterfrågan på okvalificerad arbetskraft genom att skapa förutsättningar för lägre priser och därmed ökad efterfrågan på restaurangföretagens tjänster.Under tiden efter genomförandet av den sänkta momsA significant part of the labour market debate is devoted to issues concerning problematic youth. Expressions like “the lost generation” is coined to address the very core of the matter. It captures the difficulties for low-skilled young people to gain a sustainable work life in an education-oriented society. A strategy to increase employment opportunities specifically suited for the latter group

PurposeIn early breast cancer (BC), five conventional biomarkers—estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), Ki67, and Nottingham histologic grade (NHG)—are used to determine prognosis and treatment. We aimed to develop classifiers for these biomarkers that were based on tumor mRNA sequencing (RNA-seq), compare classification performance, a

Avhandlingen Naturliga medborgare undersöker hur frilfutsliv och lägerverksamhet använts som metoder för medborgarfostran i scoutrörelsen och Unga Örnar under perioden 1925–1960. Frågorna som undersökts innefattar hur organisationerna artikulerade ideal om medborgarskap, hur barn och ungdomar skulle fostras till goda medborgare samt mer specifikt hur natur och friluftsliv skulle bidra till att för

Modern wind turbines are designed to withstand approximately for a lifetime of 20 years [1]. However, a very long design life of 100 years or more can be expected for high-quality concrete foundations. Thus there is a big difference in lifetime between wind turbines and foundations. There is a significant economic benefit of replacing the out-of-date wind turbine with a new turbine of better power