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Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and
INTRODUCTION: With the implementation of early reperfusion therapy, the number of complications in patients with acute coronary syndrome (ACS) has diminished significantly. However, ACS patients are still routinely admitted to units with high-level monitoring such as the coronary or intensive care unit (CCU/ICU). The cost of these admissions is high and there is often a shortage of beds. The aim o
Background: The molecular pathways linking short and long sleep duration with incident diabetes mellitus (iDM) and incident coronary heart disease (iCHD) are not known. We aimed to identify circulating protein patterns associated with sleep duration and test their impact on incident cardiometabolic disease. Methods: We assessed sleep duration and measured 78 plasma proteins among 3336 participants
Background: Both caveolin-1 (CAV1) and insulin-like growth factor bindings protein 7 (IGFBP7) have been linked to angiogenesis, insulin-like growth factor (IGF) receptor 1 (IGF-1R) signaling, and the tumor microenvironment. However, CAV1 and IGFBP7 have not yet been adequately characterized and investigated as potential prognostic or treatment-predictive biomarkers at the genomic, transcriptomic,
Importance: Despite increased use of antibiotic-loaded bone cement (ALBC) in joint arthroplasty over recent decades, current evidence for prophylactic use of ALBC to reduce risk of periprosthetic joint infection (PJI) is insufficient. Objective: To compare the rate of revision attributed to PJI following primary total knee arthroplasty (TKA) using ALBC vs plain bone cement. Design, Setting, and Pa
BACKGROUND: Finding ways to prolong independence in daily life among older people would be beneficial for both individuals and society. Urban green spaces have been found to improve health, but only a few studies have evaluated the association between urban green spaces and independence in daily life. The aim of this study was to assess the long-term effect of urban green spaces on independence in
Aims/hypothesis: Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His293LeufsTer7 is significantly enriched in the Finnish population, with almost 1:250 individuals as a carrier. Importantly, the FinnGen study indicates a high predisposition for heterozygous carriers to develop type 2 and gestational diabetes. However, the precise
Learn with Lena Archives - Page 2 of 2 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of P
https://rwi.lu.se/blog-category/learn-with-lena/page/2/ - 2026-07-17
GROWTH. reconsiders the notion of growth in architecture, not as a process of continuous expansion, but as a cyclical condition of emergence, stabilization, decay, and regeneration observed in natural ecosystems. Positioned between regenerative agriculture, computational design, and material-driven architectural practice, the thesis investigates how the growth cycles of biotic materials can become
Milk protein compositions play a pivotal role in physicochemical and technological properties of milk, particularly in rennet coagulation in cheese production. Conventional analytical methods such as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography–high resolution mass spectrometry (LC-HRMS) provide detailed protein characterization but require long an
Denna uppsats prövar den enskildes rättsliga ställning i en automatiserad förvaltning genom att analysera hur myndighetsövergripande beslutsmodeller förhåller sig till dataskyddsförordningens krav på skydd mot automatiserat beslutsfattande. Analysen genomförs med utgångspunkt i ett rättssäkerhetsperspektiv och har särskilt fokus på hur automatiserad profilering i ett inledande led samverkar med efThis thesis examines the legal position of the individual in an automated public administration by analyzing to what extent fragmented decision-making models can be reconciled with the requirements of the General Data Protection Regulation (GDPR) regarding protection against automated decision-making. The analysis is conducted from a legal certainty perspective and focuses in particular on how aut
Environmental claims have become a familiar feature of fashion marketing. On social media, however, they are rarely communicated in isolation. A state ment about recycled materials may appear alongside personal styling, aesthetic imagery and an influencer's endorsement. The challenge for EU consumer law is that the environmental meaning of such content may not lie in the wording alone, but in
The European Union's Nature Restoration Law aims to protect and restore the EU's ecosystems, among which specific target goals were set for urban ecosystems. This requires local authorities to assess and monitor urban tree cover (UTC), supported by strategic urban vegetation planning. As urban trees provide various benefits, including microclimate regulation, incorporating urban microclima
When greenhouse gas emissions in the building sector are considered, the focus is often on new construction. However, this is not the whole picture. Existing commercial buildings, such as office buildings, also go through several changes during their lifetime, and these changes can have a relevant climate impact. In office buildings, such changes are often called tenant adaptations, where the inte
Background and Objectives – Pyruvate dehydrogenase complex (PDHc) deficiency is a potentially treatable neurodegenerative genetic disorder. It represents a common cause of mitochondrial disease. Most published reports are limited to single cases, and population-based data are lacking. The objective of this study was to investigate the prevalence, incidence, and life expectancy and to explore genot
Background – While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mislocalization leads to cryptic exon inclusion and loss of canonical protein function. While neuronal
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Type 1 Diabetes (T1D), but a subset of individuals remains free from macrovascular or renal complications despite decades of hyperglycaemia and a significant risk factor burden. We used a targeted proteomic approach (Olink Cardiovascular panel III, targeting 92 proteins) to characterize the proteomic profile of cardiov
BACKGROUND—: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. METHODS—: To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in five prospective studies comprising 18,919 individuals of Europea
The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. DHEAS is considered an inactive precursor, which is converted into androgens and estrogens via local metabolism in peripheral target tissues. The predictive value of serum DHEAS for fracture risk is unknown. The aim of this s
