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The wastewater sector provides water sanitation to populations in order to preserve humanhealth and the natural environment. In developed countries, due among others to increasingpressures coming from climate change and population growth, the wastewater treatment isaffected and needs to adapt to such changes. As a result, effluent requirements arebecoming more stringent, nutrients and organic remo
Tilläggsköpeskillingar har kommit att användas allt mer frekvent i förvärvssammanhang. Detta gäller framför allt i fråga om företagsförvärv men finansieringsmodellen används även i andra sammanhang såsom vid förvärv av fastigheter, patent, tjänster och så vidare. En tilläggsköpeskilling går ut på att säljaren får en fast del av ersättningen vid förvärvet medan möjlighet finns till en eller flera yEarn-outs have become more frequently used in acquisitions. This is particularly true in the case of acquisitions of companies. But the funding model is widely used even in other contexts such as the acquisition of property, patents, services and so on. An earn-out is a contract where the seller receives a fixed remuneration of the acquisition at the time of the contract while the possibility exis
The public library is an institution with multiple tasks and with different parts to play in the society. The aim of this Master’s essay is to illustrate one of the many activities that libraries utilise to reach their users and to keep up with the modern society - film screening. We have studied the phenomenon mainly through case studies at four different public libraries in the Region of Skåne i
BACKGROUND: Homologous recombination deficiency (HRD) originating from inactivation of genes like BRCA1/BRCA2 is a targetable abnormality common in triple-negative breast cancer (TNBC). In estrogen-receptor (ER)-positive HER2-negative (ERpHER2n) breast cancer (BC), HRD prevalence and clinical impact are unclear.METHODS: We analyzed 502 ERpHER2n tumors from patients recruited via the population-rep
Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic p
BackgroundUmbilical cord arterial pH (UApH) is the most objective measurement of the metabolic condition of the infant at birth. However, studies have identified changes in UApH with advancing gestational age, as there is limited data examining UApH changes with different modes of birth. The objective was to establish reference values for UApH according to mode of birth and to investigate the infl
Introduction: Implementing new treatment regimens entails a learning phase with a concomitant risk of suboptimal results. High caseload has generally been shown to improve results in complex surgical procedures. This study aimed to evaluate results of Cytoreductive Surgery (CRS) and Intraperitoneal Chemotherapy (IP), given as Early Postoperative Intraperitoneal Chemotherapy (EPIC) or Hyperthermic
BACKGROUND: Global longitudinal strain (GLS) and left atrial strain metrics, including reservoir (LAr), contraction (LAct), and conduit strain (LAcd), have emerged as key indicators of left ventricular (LV) function and filling pressures. However, the prognostic value of these markers for risk stratification in acute heart failure (HF) remains uncertain, particularly in identifying patients at ele
Background: In addition to impairing the lung function, chronic obstructive pulmonary disease (COPD) also affects phonatory characteristics. Recent research highlights the potential of voice as a digital biomarker to support clinical decision-making. While machine learning (ML) can detect disease patterns from acoustic features, clinical relevance requires understanding the relationship between th
People with intellectual disabilities have an increased risk of diabetes mellitus (DM). They tend to develop it at earlier ages than the general population, resulting in even higher risks in younger people. However, few studies have separated Type 1 and Type 2 DM. The aim of this study was to assess prevalence of different types of DM in different age groups in relation to the general population.
Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteomics dataset from the IMPOCT, RAMP and S3WP-T2D clinical trials in 98 participants before and after metformin e
BACKGROUND: n-3 (ω-3) long-chain polyunsaturated fatty acids (n-3 LCPUFAs) have anti-inflammatory effects that may influence immune-mediated diseases.OBJECTIVES: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower incidence of infection in young children.METHODS: We used data from 3 Nordic cohorts: the Norwegian Mother, Father and Child Cohort study (M
Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and without type 2 diabetes (T2D). Methods Bayesian network analyses and complementary two-sample Mendelian randomization were used to quantify causal pathways link
BACKGROUND: Several studies have sought to investigate gambling craving and its potential contribution to gambling problems. One aim of this line of research has been to further examine whether craving should be considered a separate diagnostic criterion for gambling disorder, which it currently is not. The present study aimed to investigate the relationship between craving and other risk factors—
Background: Heart diseases are among the leading causes of disease burden worldwide with often a large impact on the lives of the affected individuals. The association between heart disease and depression is well-known and elevated suicide risk has been demonstrated in several types of heart disease. The aim of this study was to investigate what health care contacts individuals with heart disease
HVAC systems have the purpose of improving indoor air quality in buildings to enhance appropriate occupants- comfort, health and good productivity. Window airing may be one measure to consider in the absence of occupant control of the ventilation and by that, we mean occupants opening windows and doors. Approximating the volume of air exchanged during window airing is important in understanding th
