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AbstractGiant Cell Arteritis (GCA) is the most common vasculitis in adults among people in the western world. The pathogenesis and etiology are not fully understood.In Study I, we investigated potential predictors for developing GCA, i.e. Body Mass Index (BMI), smoking and hormone-related factors, in a nested case control study. We identified cases and matched controls (4/case) who previously had
Background: Radiation Therapy (RT) is a common treatment after breast cancer surgery and a complex process using high energy X-rays to eradicate cancer cells, important in reducing the risk of local recurrence. The high-tech environment and unfamiliar nature of RT can affect the patient’s experience of the treatment. Misconceptions or lack of knowledge about RT processes can increase levels of anx
BACKGROUND: Bivalirudin was not superior to unfractionated heparin in patients with myocardial infarction (MI) treated with percutaneous coronary intervention and no planned use of GPI (glycoprotein IIb/IIIa inhibitors) in contemporary clinical practice of radial access and potent P2Y12-inhibitors in the VALIDATE-SWEDEHEART randomized clinical trial (Bivalirudin Versus Heparin in STEMI and NSTEMI
Background: Accurate information about chemotherapy drugs and regimens is needed to reduce chemotherapy errors. A national e-library, as a common knowledge source with standardized chemotherapy nomenclature and content, was developed. Since the information in the library is both complex and extensive, it is central that the users can use the resource as intended.Objective: The aim of this study waBackground:Accurate information about chemotherapy drugs and regimens is needed to reduce chemotherapy errors. A national e-library, as a common knowledge source with standardized chemotherapy nomenclature and content, was developed. Since the information in the library is both complex and extensive, it is central that the users can use the resource as intended.Objective:The aim of this study was
AIMS: Patients awaiting orthotopic heart transplantation (OHT) can be bridged utilizing a left ventricular assist device (LVAD) that reduces left ventricular filling pressures, decreases pulmonary artery wedge pressure, and maintains adequate cardiac output. This study set out to examine the poorly investigated area of if and how pre-treatment with LVAD impacts right ventricular (RV) function foll
The concept of institutional logics is key to those who investigate organizational change, especially those who seek to understand the tension and impact of combining the logics of market and mission. Such a combination of logics, being an espoused financial sustainability solution for the funding-scarce nonprofit sector, is an increasingly prominent phenomenon. While there are several studies on
PurposeThe purpose of this paper is to analyse the impact of six energy consumption factors (unsold products, product returns, packaging, freight transport, passenger transport and buildings) on the total energy consumption in three types of distribution channels for e-commerce and conventional trade.Design/methodology/approachThe study uses a quantitative calculation model where input data for th
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Studies of the immunopathogenesis in JIA has mainly focused on the adaptive immune system, while less is known of the role of the monocytes. JIA is considered a chronic disease, although only about 50% of participants in long-term follow-up studies have active disease as adults. The treatment arsenal for JIA has
Background: To pursue high quality research, successful participant recruitment is essential, but recruitment rates are often low. This is specifically true in target populations with impairments, for instance, among stroke survivors. Previous studies focusing on recruitment have mainly relied on information from professionals, and there is therefore a need to contribute with new methodological in
Breast cancer is the most common type of cancer globally. Early detection is important for reducing the morbidity and mortality of breast cancer. The aim of this study was to evaluate the performance of different machine learning models to classify malignant or benign lesions on breast ultrasound images. Three different convolutional neural network approaches were implemented: (a) Simple convoluti Breast cancer is the most common type of cancer globally. Early detection is important for reducing the morbidity and mortality of breast cancer. The aim of this study was to evaluate the performance of different machine learning models to classify malignant or benign lesions on breast ultrasound images. Three different convolutional neural network approaches were implemented: (a) Simple convolut
Background: Prophylactic lightweight mesh in the sublay position reduced the cumulative incidence of parastomal hernia (PSH) after cystectomy with ileal conduit diversion in a randomised controlled trial.Objective: To investigate whether the use of prophylactic mesh is cost-effective in comparison to no mesh from the health care provider perspective.Design setting and participants: Data on health
BACKGROUND: Prospective and detailed investigations of smoking and prostate cancer (PCa) risk and death are lacking.OBJECTIVE: To investigate prediagnosis smoking habit (status, intensity, duration, and cessation) as a risk factor, on its own and combined with body mass index (BMI), for PCa incidence and death.DESIGN, SETTING, AND PARTICIPANTS: We included 351448 men with smoking information from
BackgroundAdrenomedullin is a vasoactive hormone with potentially prognostic and therapeutic value, which mainly has been investigated in intensive care unit (ICU) settings. The triaging in the emergency department (ED) of patients to the right level of care is crucial for patient outcome.ObjectivesThe primary aim of this study was to investigate the association of bioactive adrenomedullin (bio-AD
Objectives The primary aim of the present study was to investigate the putative excess mortality by suicide in suicide attempters. As a secondary aim, we investigate excess mortality in specific, clinically relevant subgroups: individuals with repeated suicide attempts (RA); individuals who used violent method at the attempt (VA); and those who scored high on the Suicide Intent Scale (HS) at the t
RATIONALE: Vascular calcification is a prominent feature of late-stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a proteoglycan involved in bone mineralisation, associate with diabetes and CVD. We hypothesised that OMD could be implicated in these diseases via vascular calci
BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the effici
Disaster-induced and conflict-induced forced displacements areamong the biggest humanitarian and development challenges of the countriesaround the world in the 21st century. The increasing rate of the forced displacementputs significant pressure on the built environment which popularly includes thechallenges associated with delivering the essential goods and services, providingadequate and appropr
Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) are co-factors of serum response factor (SRF) that activate the smooth muscle cell (SMC) gene program and that play roles in cardiovascular development and mechanobiology. Gain and loss of function experiments have defined the SMC gene program under control of MRTFs, yet full understanding of their imp
Emotion regulation has been specifically linked to both non-suicidal self-injury (NSSI) and attempted suicide. It is also known that self-harm is disproportionally higher (30–68.4%) in forensic samples than in the general population, yet knowledge about the association between emotion regulation and self-harm in forensic settings is scarce. The purpose of this study was to describe emotion regulat
