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Background: Dose-dense (DD) adjuvant chemotherapy improves outcomes in early breast cancer (BC). However, there are no phase 3 randomized data to inform on its combination with trastuzumab for patients with human epidermal growth factor receptor 2 (HER2)–positive disease. Methods: This was a protocol-predefined secondary analysis of the randomized phase 3 Pan-European Tailored Chemotherapy (PANTHE

Autoantibodies of different specificites have been described in association with glomerulonephritis and therefore the aim of this thesis was to improve our knowledge of the different manifestations of autoimmune phenomena which are involved in the glomerulonephritides. Special reference is made to Wegener´s granulomatosis (WG) and microscopic polyangiitis (MP) which are frequently associated with

Den dokumentvillkorade garantin, som i praktiken vanligen betecknas som självständig, känneteck-nas av att villkoren i utfästelsen väsentligen endast innefattar villkor som refererar till att vissa angivna dokument presenteras för garanten. Dokumentvillkorade garantier förekommer vanligtvis i avtalsstrukturer som involverar ett flertal olika avtal och parter. De typer av avtal som omfattas av sådaDocumentary guarantees, in practice usually described as independent guarantees, are characterized by the fact that they essentially contain only conditions referring to whether or not certain specified documents are presented to the guarantor. A documentary guarantee is usually only one part of a contractual structure involving several contracts and parties. Such contracts give rise to special le

Metrical versions of the Passion form a significant part of the substantial body of devotional literature written in Europe during the 17th and 18th centuries. The aim underlying them was twofold: to meet the demand for works which could be used for purposes of educadon, edification, and private worship but also to show that the vanacul-ars could be used to produce distinguished works written in a

As the contribution of dispersed or distributed energy resources (DER) to the electric power production increases, the effects on the power system grow more important. As an example a critical situation may arise if protective relays trip a large part of the dispersed generation due to undervoltage at a short-circuit event. On the other hand it is crucial that the protection system acts correctly

Innovation has been regarded a crucial means by which organizations adapt to the changes in the environment. Previous studies have identified organizational culture as a key factor that influences innovation, suggesting that a culture with certain characteristics can lead to superior innovation performance. This culture is referred to as “innovation culture”, a notion which has recently enjoyed gr

In the discipline of archaeology death has always been a common subject. Graves and dead bodies in different states of decay are important sources of information. This dissertation investigates how our relation to death can be mirrored through some of the better-known individuals from prehistory in Scandinavia. Because of the character of the question at issue I start with three chapters in which

The sensation of dryness and irritation is essential in the sick building syndrome (SBS), and such symptoms are common in both office and hospital employees. In Scandinavia, the indoor relative humidity in well ventilated buildings is usually in the range 10-35% in winter. The aim of this study was to evaluate the effect of steam air humidification on SBS and perceived air quality during the heati

AIMS: People with Type 1 diabetes have smaller pancreases than healthy individuals. Several diseases causing pancreatic atrophy are associated with pancreatic steatosis, but pancreatic fat in Type 1 diabetes has not been measured. This cross-sectional study aimed to compare pancreas size and fat fraction in children with Type 1 diabetes and controls.METHODS: The volume and fat fraction of the panc

BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without