Sökresultat
Filtrera
Filtyp
Din sökning på "swedish" gav 92125 sökträffar
Identifying work ability promoting factors for home care aides and assistant nurses
Background: In workplace health promotion, all potential resources needs to be taken into consideration, not only factors relating to the absence of injury and the physical health of the workers, but also psychological aspects. A dynamic balance between the resources of the individual employees and the demands of work is an important prerequisite. In the home care services, there is a noticeable t
Dose and plasma concentration of galantamine in Alzheimer's disease - clinical application
Introduction: Patients with Alzheimer's disease (AD) are currently treated with cholinesterase inhibitors, such as galantamine, without actual knowledge of its concentration in plasma. Our objective was to analyse potential relationships between galantamine concentration, galantamine dose, socio-demographic characteristics, body weight, body mass index (BMI), and treatment response. Methods: Eight
Study of Functional Variants of the BANK1 Gene in Rheumatoid Arthritis
Objective. To investigate 1 functional (rs17266594) and 2 potentially functional (rs10516487 and rs3733197) BANK1 variants, which were previously identified as systemic lupus erythematosus (SLE) susceptibility markers, to test whether they are associated with rheumatoid arthritis (RA). Methods. Four different cohorts were included in the study: 1,080 RA patients and 1,368 healthy controls from Spa
Economic stress in childhood and adulthood, and self-rated health: a population based study concerning risk accumulation, critical period and social mobility
Background: Research in recent decades increasingly indicates the importance of conditions in early life for health in adulthood. Only few studies have investigated socioeconomic conditions in both childhood and adulthood in relation to health testing the risk accumulation, critical period, and social mobility hypotheses within the same setting. This study investigates the associations between eco
Evidence for Presence and Functional Effects of Kv1.1 Channels in beta-Cells: General Survey and Results from mceph/mceph Mice
Background: Voltage-dependent K+ channels (Kv) mediate repolarisation of beta-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K+ channel in this process is however unclear. We tested for presence of Kv1.1 in different species and tested for a functional role of Kv1.1 by assessing pancreatic islet function in BALB/cByJ (wild-type) and megencephaly (mceph/mceph)
Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
Background: Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored. Objective: The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk
Vårdkedja för ungdomar eller professionella? En processutvärdering av projektet ”Motverka våld och gäng”
Syftet med denna studie är att analysera hur de involverade aktörerna upplever, definierar och tolkar ett behandlingsprojekt, som involverade samhällsomhändertagna ungdomar. Projektet involverade olika myndigheter vars representanter skulle innefatta en vårdkedja och benämndes Motverka Våld och Gäng (MVG-projektet). I projektet var också ett antal samordnare anställda. Utöver redovisningen av våra
Brittle tectonothermal evolution in the Forsmark area, central Fennoscandian Shield, recorded by paragenesis, orientation and Ar-40/Ar-39 geochronology of fracture minerals
In this paper, we show how studies of fracture mineral paragenesis, their orientation and Ar-40/Ar-39 geochronology can be applied in order to recognise the brittle tectonothermal evolution in an area. Samples were selected from nearly 18 km of drill cores from the upper I km of the Fennoscandian Shield obtained during the site investigation for a repository of spent nuclear fuel in Forsmark, cent
Humor i romantisk text : om Jean Pauls estetik i svensk romantik: C.F. Dahlgrens Mollbergs epistlar (1820), C.J.L. Almqvists Amorina (1822) och C. Livijns Spader Dame (1825)
Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project
Background: Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC related to other metabolic risk factors. We aimed to examine the risk of EAC and ESCC in relation to metabolic risk factors, separately and combined in a prospective cohort study. Metho
One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor : A Randomized Trial
Context Adjuvant imatinib administered for 12 months after surgery has improved recurrence-free survival (RFS) of patients with operable gastrointestinal stromal tumor (GIST) compared with placebo. Objective To investigate the role of imatinib administration duration as adjuvant treatment of patients who have a high estimated risk for GIST recurrence after surgery. Design, Setting, and Patients Pa
Nt-proANP in plasma, a marker of salt sensitivity, is reduced in type 2 diabetes patients.
Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type
High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL
GenoMEL, comprising major familial melanoma research groups from North America, Europe, Asia, and Australia has created the largest familial melanoma sample yet available to characterize mutations in the high-risk melanoma susceptibility genes CDKN2A/alternate reading frames (ARF), which encodes p16 and p14ARF, and CDK4 and to evaluate their relationship with pancreatic cancer (PC), neural system
Konversion och konfession – om konversionsliknande övergångar hos Henric Schartau och F. G. Hedberg i relation till en andra konfessionaliseringsperiod
Conversion and Confession – Religious Transitions similar to Conversion in Henric Schartau and F. G. Hedberg, related to a Second Confessional Age The nineteenth century has often been called an Age of Secularisation. This has been criticized as blindness of religion. The »long» nineteenth century meant a mobilization of religion. German Historian Olaf Blaschke has interpreted the period as a sec
Professional's and older person's assessments of functional ability, health complaints and received care and service. A descriptive study.
OBJECTIVE: The aim of the study was to investigate the level of agreement between the needs assessment made by professional on the one hand, and the older person's views on the other. A further aim was to explore if the estimations made by the professional were systematically lower or higher compared to the views of the older person. PARTICIPANTS: The study included 152 individuals, 65+, who recei
Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase.
Parathyroid hormone (PTH) is secreted from the parathyroid glands in response to low plasma calcium levels. Besides its classical actions on bone and kidney, PTH may have other important effects, including metabolic effects, as suggested for instance by increased prevalence of insulin resistance and type 2 diabetes in patients with primary hyperparathyroidism. Moreover, secondary hyperparathyroidi
The epidemiology of Graves' disease: Evidence of a genetic and an environmental contribution.
Previous family and twin studies have indicated that Graves' disease has a heritable component. Family studies have also shown that some autoimmune disease cluster in families and genetic studies have been able to show shared susceptibility genes. In the present nation-wide study we describe familial risk for Graves' disease among parents and offspring, singleton siblings, twins and spouses with r
Common variation in PPARGC1A/B and progression to diabetes or change in metabolic traits following preventive interventions: the Diabetes Prevention Program.
AIMS/HYPOTHESIS: PPARGC1A and PPARGC1B encode transcriptional coactivators that regulate numerous type 2 diabetes-related metabolic processes. Common genetic variation across PPARGC1A/B was characterised by genotyping tagging variants. We then tested associations of these variants with diabetes incidence or change in quantifiable metabolic traits directly or via interactions (with metformin treatm