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OBJECTIVE Chronic subdural hematoma (CSDH) is a common cause of morbidity in the older population and the incidence of CSDH is likely to increase in upcoming years due to the increasing age of the population. Surgical intervention is the cornerstone of treatment, but trials have shown conflicting results regarding the optimal type of surgical drainage. The aim of this study was to compare outcomes

PURPOSE. Epithelial maturation is essential for the specificity and functionality of retinal pigment epithelial (RPE) cell models. This study investigates how different maturation conditions shape RPE characteristics and cellular complement biology in two commonly used in vitro models: ARPE-19 and induced pluripotent stem cell–derived RPE (iPSC-RPE). METHODS. ARPE-19 and iPSC-RPE cells were cultur

Purpose To evade immunosurveillance many cancers convert tryptophan (Trp) into kynurenine (Kyn), which induces immunotolerance and suppresses immune responses. Elevated Kyn amounts have been found in blood from patients with cutaneous melanoma. This study aimed to investigate whether higher Kyn abundance and lower Trp abundance can be detected on the surface of cutaneous melanoma lesions compared

Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14) has been detected in foam cell-rich regions of atherosclerotic plaques, but whether it has a role in plaque stability is not known. This study investigates the association betw

Objective: To evaluate the effectiveness of telemedicine-delivered diet and/or exercise interventions to prevent type 2 diabetes (T2D) in people at risk. Methods: Embase (via Ovid), Medline (via Ovid), Web of Science, CINAHL, Scopus and SciELO were searched from January 2010–December 2020 for intervention studies using a diet and/or exercise intervention delivered through telemedicine for T2D prev

Introduction: Infection remains the most common treatment-related toxicity of childhood ALL, emphasizing the need to identify patients at risk and to tailor treatment strategies accordingly. Aims: The primary aim was to compare infectious toxicity during early treatment for childhood ALL following the ALLTogether and NOPHO ALL-2008 (ALL-2008) protocols, and second, to identify risk factors for inf

Climate change has intensified the mobility of dissolved organic matter (DOM) from land into aquatic ecosystems leading to increased brownification and hypoxia. Constructed wetlands (CWs) offer a potential mitigation strategy, yet optimal wetland design and water residence time (WRT) with respect to DOM removal remains underexplored. This study evaluates the effects of shallow and deep CWs on the

En rad internetbaserade tjänster finansieras idag genom att samla in data om sina användare för att sedan sälja riktat reklamutrymme till andra aktörer. Konsumenter får ofta tillgång till tjänsterna inte genom att betala pengar, utan i stället genom att tillhandahålla sina personuppgifter och acceptera att dessa behandlas i marknadsföringssyfte. Genom EU-direktiv 2019/770 och dess implementation A number of internet-based services are in today’s digital economy financed by collecting data about their users in order to sell targeted advertising space to other actors. Consumers often gain access to these services not by paying money, but by providing their personal data and allowing for it to be process-sed for marketing purposes. Through EU Directive 2019/770 and its implementation in the

Introduction: The Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ. These proteins shuttle between the nucleus and cytoplasm in response to Hippo pathway activity, which, when active, leads to cytoplasmic sequestration and degradation of YAP/TAZ, preventing them from initiating gene transcription. Although ini

BACKGROUND: The involvement of the complement system in anti-glomerular basement membrane (GBM) disease is well known but incompletely characterized. The ability of autoantibodies to trigger the classical pathway is evident, while the lectin and alternative pathways also seem to be of importance. We studied complement activation in patients treated with imlifidase, which leads to rapid IgG depleti

Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children

Background: Transcatheter aortic valve replacement (TAVR) is increasingly used in patients with bicuspid aortic valve (BAV) stenosis, but there is limited comparative data on balloon-expandable (BEV) versus self-expanding valves (SEV) in this population. Aim: To compare clinical and hemodynamic outcomes between BEVs and SEVs in patients with BAV stenosis. Methods: This observational cohort include

Alkoholkonsumtion är vanligt förekommande bland vuxna, och över 80 procent i Sverige uppger att de dricker alkohol årligen. När alkoholkonsumtionen påverkar individens arbetsförmåga kan den medföra betydande risker för både säkerhet och arbetsmiljö. Höga krav ställs därför på arbetsgivaren. Via en rättsdogmatisk metod syftar uppsatsen till att analysera och jämföra arbetsgivarens ansvar vid alko

How travellers perceive the quality of public transport services has profound influence on their satisfaction and thus of their inclination to choose this mode of transport. Punctuality, which may be interpreted as timetable adherence or overall travel time predictability, is often pointed out as the most important constituent of overall service reliability of public transport systems. However, in

I ett aktiebolag har aktieägarna inte något personligt betalningsansvar för bolagets förpliktelser, vilket framgår av 1 kap. 3 § aktiebolagslagen (2005:551) (ABL). Ak- tieägarnas frihet från personligt betalningsansvar balanseras av lagregler som skyd- dar bolagets borgenärer. I doktrin och förarbeten har det även diskuterats om ak- tieägare eller andra trots huvudregeln i 1 kap. 3 § ABL, med stöd

Nästan hela Sveriges befolkning bor i städer, varav många är byggda utifrån tidigare klimatförhållanden där extrema skyfall, stigande havsnivåer och jordskred inte var lika vanligt förekommande som i dag. Detta kan leda till översvämmade bostäder, förstörda vägar och utslagen infrastruktur. För att vi ska kunna fortsätta leva i våra städer måste bebyggelsen anpassas till dagens och morgondagens kl

Introduction: The optimal timing for distal radial fracture fixation remains controversial. Most previous studies have dichotomized timing into early or delayed categories, potentially obscuring the true effect of delay. This study investigated surgical timing as a continuous variable to determine its influence on radiographic alignment. Methods: In a retrospective multicentre cohort study, we rev