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When developing products, engineering designers often face the problem that their candidate for a technical solution, ranging from a concept to a detailed design, needs to be analyzed by a design analyst before it is approved or rejected and the engineering designer can continue his/her activities within the product development process. If engineering designers have to send every solution candidat
Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland
Popular AbstractAvhandlingen undersöker relationen mellan individer och platser relaterat till livskriser och existentiell trygghet. Författaren analyserar olika copingstrategier hos gravida kvinnor och hur detta förändrar deras relation till olika platser i deras livshistoria. Anthony Giddens begrepp ontologisk trygghet granskas kritiskt i förhållande till existentiell välmående och används sedanThe study explores the importance of place attachment on individuals? sense of security during existential crises. Coping strategies of pregnant women are analysed, focusing on how the prospect of giving birth affects their relationship to place. Anthony Giddens? concept of ontological security is critically examined and used to investigate the connection between place and ontological security ? w
This dissertation argues that lower-level military leaders, commanding between a dozen and a few hundred troops, can have a major political and strategic impact. Furthermore, it is argued that the decisions made by these lower-level military leaders are shaped by subcultures, in particular under conditions of stress and uncertainty. The concept of tactical-level subcultures is defined, drawing on
The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and function, independently of their role in potentiating insulin secretion after a meal. Th
Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation and motile function. Binding of SRF to DNA is mediated by genetic elements called CArG boxes, found often but not exclusively in muscle and growth controlling genes. Studies aimed at defining the full spectrum of these CArG
Although bottom water hypoxia (O2 −1) is presently widespread in the Baltic Sea coastal zone, there is a lack of insight into past changes in bottom water oxygen in these areas on timescales of millennia, and the possible driving factors. Here, we present a sediment-based environmental reconstruction of surface water productivity, salinity and bottom water oxygen for the past 5400 years at Gåsfjär
Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee an
Objective: The aim of this study was to assess the mortality in hip fracture patients with regard to use of fall-risk-increasing drugs (FRIDs), by comparing survival in exposed and nonexposed individuals. Design: This was a general population-based cohort study. Settings: Data on hip fracture patients were retrieved from three national databases. Participants: All hip fracture patients aged 60 yea
Fuel cells produce low quantities of local emissions, if any, and are therefore one of the most promising alternatives to internal combustion engines as the main power source in future vehicles. It is likely that urban buses will be among the first commercial applications for fuel cells in vehicles. This is due to the fact that urban buses are highly visible for the public, they contribute signifi
In Parkinson's disease (PD), pathological microstructural changes occur and such changes might be detected using diffusion magnetic resonance imaging (dMRI). However, it is unclear whether dMRI improves PD diagnosis or helps differentiating between phenotypes, such as postural instability gait difficulty (PIGD) and tremor dominant (TD) PD. We included105 patients with PD and 44 healthy controls (H
Little is known about the extent to which interactions between genetics and epigenetics may affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We performed a genome-wide DNA methylation quantitative trait locus (mQTL) analysis in human adipose tissue of 119 men, where 592,794 single nucleotide polymorphisms (SNPs) were related to DNA methylation of 477,891 CpG site
Type 2 diabetes has become a leading health problem throughout the world. The escalating epidemic of type 2 diabetes is believed to result from a collision between inherent biological susceptibilities (genotypes) and a shift toward dietary habits and lifestyle that promote obesity over the past several decades; the transition from “traditional” to modern “obesogenic” lifestyles is characterized by
The emergent nature of the innovation process has always rendered it an elusive subject of study. Nonetheless, academics remained undeterred in their attempts to articulate the innovation process in academics terms as attested by the growing amount of research on the topic. Existing theories for explaining innovation (or the lack of innovation) center on empirical samples from large firms in the h
