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Increased PDGFRA signaling is an essential pathogenic factor in many subtypes of gliomas. In this context the cell surface expression of PDGFRA is an important determinant of ligand sensing in the glioma microenvironment. However, the regulation of spatial distribution of PDGFRA in glioma cells remains poorly characterized. Here, we report that cell surface PDGFRA expression in gliomas is negative
Background: The need for a mobile workforce inevitably means that the length of the total work day (working and traveling time) will increase, but the health effects of commuting have been surprisingly little studied apart from perceived stress and the benefits of physically active commuting. Methods: We used data from two cross-sectional population-based public health surveys performed in 2004 an
Mitochondrial dysfunction is implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity. Little is known about the influence of the TOMM40 gene on hippocampal (HC) volume and episodic memory (EM), particularly in healthy older adults. Thus, we sough
Five representative, and essentially dissimilar, novels by Ulla Isaksson are analysed in this book: the Christian novel Ytterst i havet (1950); the love story De två saliga ("The Blessed Ones" 1962); two novels dealing with feminine problems, Kvinnohuset (1952) and FödelseDagen (1988); and the historical novel Dit du icke vill (1956). The final chapter, on Dit du icke vill , also looks at the Chri
The main ambition of companies is to deliver products (or services) to customers successfully in order to remain competitive. This requires an efficient and effective product development process, as well as cost reductions and higher service levels through improved logistics performance in the supply chain. Traditionally, these two areas, i.e. product development and logistics, have been treated s
This chapter provides a synthesis of three earlier published studies (Garmy et al. 2012a; Garmy et al. 2012b; Garmy et al. 2013) (survey I) as well as previously unpublished results from a survey conducted in 2013 among students aged 16 (survey II). Objective: The aim was to investigate the effects of sleep, television use and texting and computer habits on overweight, enjoyment of school and fee
This intermediate report presents some of the important findings of the research work carried out during the first three years of the CHRISGAS project. The report is aimed at a broad technical-oriented audience such as: engineers with a general interest in the state-of-the-art and new developments in the biomass-to automotive fuel sector, and/or to teachers/lecturers/students in technical subjects
Atmospheric aerosol particles have substantial influence on climate and air quality. However, the anthropogenic influence on the atmospheric aerosol is still poorly known. This limits the understanding of past and future climate changes. Additionally, both epidemiological and toxicological studies indicate adverse health effects of inhaled aerosol particles. In order to study the effect of atmosph
On the basis of cross-sectional studies in elite athletes and longitudinal studies, physical activity in growing children has been suggested to enhance bone mineral acquisition and prevent osteoporosis later in life. The level of exercise in most of these studies is not applicable in a population on a day-to-day basis. The aim of this study was to determine whether moderate increased exercise with
The importance of different additional simplifications used when moving from single site applications to regional applications of the SAFE and MAKEDEP models was studied. The SAFE model is a dynamic soil chemistry model, which apart from physical and chemical soil parameters also needs the historic evolution of atmospheric deposition and nutrient uptake to simulate the effects of acidic deposition
OBJECTIVE: To investigate whether patients with severe radiographic osteoarthritis (OA) have a different outcome at one year after total hip replacement than patients with moderate radiographic OA. To investigate sex related differences in preoperative radiographic and self reported status and in postoperative outcome.METHODS: 184 patients (96 women) with a mean age at surgery of 71.4 years (50-92
Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?
