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Objective: Advanced glycation end products (AGE) have been implicated in diabetic vascular complications through activation of pro-inflammatory genes. AGE-modified proteins are also targeted by the immune system resulting in the generation of AGE-specific autoantibodies, but the association of these immune responses with diabetic vasculopathy remains to be fully elucidated. The aim of this study w
Background-Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. Methods and Results-To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinct met
Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in the western world. HUS is characterized by the triad of hemolytic anemia, thrombocytopenia and renal failure. There are two main subtypes of HUS; typical or D+ (D stands for diarrhea) HUS associated with enterohemorrhagic E. coli (EHEC) infection, which accounts for about 90% of all HUS cases, and atypic
OBJECTIVE-Mutations in the hepatocyte nuclear factor (HNF)-1 alpha, HNF-4 alpha, glucokinase (GCK), and HNF-1 beta genes cause maturity-onset diabetes of the young (MODY), but it is not known whether common variants in these genes predict future type 2 diabetes. RESEARCH DESIGN AND METHODS-We tested 14 previously associated polymorphisms in HNF-1 alpha, HNF-4 alpha, GCK, and HNF-1 beta for associa
Populärvetenskaplig sammanfattning Jorderosion är traditionellt sett kopplat till jordbruk i semiJorderosion är traditionellt sett kopplat till jordbruk i semi-arida och tropiska områden men har blivit ett omfattande problem världen över, såväl på storskalig och lokal nivå.Jordförluster leder till både minskad produktivitet på åkerfälten och till sedimentförluster med både minskad produktivitet påTraditionally, soil erosion has been mostly associated with agriculture in semi-arid and tropical areas. Still, soil erosion is a hazard over the whole globe, both on a broad and a small scale. The consequences of soil loss may be both lower productivity on the agricultural fields and also nutrient leaching that leads to a higher level of nitrogen and phosphorous in streams and water bodies. The h
Populärvetenskaplig sammanfattning: De skånska bokskogarna. Vad kan krypen säga? Det är mycket som påverkar våra skogar i dag. Vägar som delar upp dem i mindre delar och lantbruk och kvävenedfall som stör balansen för vad som ska växa i skogens utkanter med sin gödsling. Även trafiken påverkar genom att kväveoxiderna i avgaserna har en gödande effekt. Skogens hälsa påverkas självklart av detta, Abstract Deforestation, fragmentation and loss of biodiversity, all are elements that are common today. With this project I want to evaluate if there is a difference in functional diversity of evertebrates between beech stands of low herb and shrub type beech forest. I also want to test if there is a difference within tested areas between low herb and shrub type forests, but also if here is a dif
The purpose of this paper is to examine the reasons or motives for firms with enough capital investment, thus not financially incapacitated, but still utilizing some form of financial bootstrapping in their daily operations. This paper uses the empirical findings on techniques and motives for bootstrapping according to Winborg and Landström (2001) and Winborg (2009) as a basis for analysis to eval
Titel Försäljningskanalernas roll för varumärkeskapitalet – en kvantitativ studie om modeföretags val av försäljningskanaler Seminariedatum 2013-06-05 Ämne/Kurs FEKH29 Företagsekonomi: Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare Carolina Laurén, David Nilsson & Maria Rangin Handledare Clara Gustafsson Nyckelord Varumärkeskapital, Brand Resonance MoTitle The sales channels role of brand equity - a quantitative study of the fashion companies choice of sales channels Seminar date 2013-06-05 Course FEKH29 Business Administration: Degree Project in Marketing, Undergraduate Level, 15 University Credits Points (ECTS) Authors Carolina Laurén, David Nilsson, Maria Rangin Advisor Clara Gustafsson Key words Brand Equity, Brand Resonance Mo
The increasing trends of immigration in the affluent North nation-states from the global South has led to the growing awareness of the problem of immigrants' political integration and their resulting participation in the existing political systems of this nation.The importance of this subject is underscored by the challenges posed to the established understanding of nation and citizenship, on
Author: Hanna Hansson Title: A problem in alteration - A study of the construction of men's violence against women as a social problem [Translated title] Supervisor: Stig Linde Assessor: Ingrid Sahlin The purpose of this study was to examine the constrution of men’s violence against women. More specific, the aim was to look at the consequenses of these changes in the construction of victims a
Innovation is a dynamic process that has been extensively studied by researchers across different fields: a variety of frameworks and mental models have been produced as a result of efforts to measure and manage innovations. However, despite its obvious importance to the success of an innovation process, the “culture” of innovation remains an uninvestigated “black box”. Our thesis examines the com
Abstract Author: Sebastian Hallin Title: To speak, talk or chat: a study of social workers reflections on approaches to communication, parlance and expression. [translated title] Supervisor: Helena Hansson The purpose of this study was to investigate social workers that work with clients in substance abuse and addiction problems. The study aimed to visualize approaches to parlance, communication
Grooming är en systematisk process, som för det första kränker barn och för det andra möjliggör att barn kan utsättas för fysiska övergrepp. Barn blir lurade särskilt av gärningsmän då de inte har samma skyddsmekanismer och riskmedvetande som en vuxen person. Kommunikationsteknologins framväxt under 2000-talet har utökat möjligheterna för vuxna som vill ta kontakt med barn i sexuellt syfte. År 200Grooming is a systematic process, which firstly violates children, and secondly enables children to be subjected to physical forms of abuse. Children are deceived especially as they lack the same psychological safety mechanisms and risk awareness as that of an adult. The growth of communications technology during the 21st century has increased the possibilities for adults that seek contact with ch
Arsenik är ett mycket giftigt ämne som finns i berg, mark och grundvatten, och är känt för att orsaka allvarliga hälsoeffekter. Neurologiska skador hos människan inträffar vid koncentrationer så låga som 100 μg/L, medan 1–3 mg/kg kroppsvikt As är en dödlig dos. Exponering för As kan leda till bland annat cell- och DNA-skador, ett antal sjukdomar och störningar samt olika typer av cancer. Höga As-kArsenic is a very toxic element present in rocks, soils, and natural groundwater, and known to cause serious health effects. Neurological damage is known in humans to occur at concentrations as low as 100 μg/L, while 1–3 mg/kg of body weight As is a lethal dose. Exposure to As may lead to e.g. cellular injury and DNA damage, a number of diseases and disorders and several types of cancer. High conc
De senaste åren har en ny typ av avancerade robotar utvecklats som har en hög grad av teknisk autonomi. Tack vare artificiell intelligens kan de fatta självständiga beslut och självständigt verka i nya miljöer. För att skadeståndsansvar ska uppkomma då en sådan smart robot orsakar skada måste skadan kunna hänföras till en mänsklig aktör. Enligt Europaparlamentets resolution om civilrättsliga bestäThe past few years a new type of advanced robots have developed that possess a high degree of technical autonomy. Because of the developments in artificial intelligence they can make autonomous decisions and act independently in new environments. When that kind of smart robots cause damage, existing liability rules cover damage that can be traced back to a human agent. According to the European Pa
