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BACKGROUND & AIMS: Liver tight junctions (TJs) establish tissue barriers that isolate bile from the blood circulation. TJP2/ZO-2-inactivating mutations cause progressive cholestatic liver disease in humans. Since the underlying mechanisms remain elusive, we characterized mice with liver-specific inactivation of Tjp2.METHODS: Tjp2 was deleted in hepatocytes, cholangiocytes, or both. Effects on

Objective: Female childhood cancer survivors (CCS) are at risk of several late effects, such as metabolic syndrome (MetS) and premature ovarian insufficiency (POI). The objective is to study if POI is associated with risk of MetS and increased cardiovascular risk in CSS. Design: A cross-sectional study with a median time since the cancer diagnosis of 25 (12-41) years. Patients and controls were re

AbstractDe senaste årtiondena så har shoppingens geografiska manifestationer förändrats i grunden. Den förmodade ”döden” som har förutspåtts för shopping i stadskärnor har blivit alltmer angeläget. Vetenskapliga studier har undersökt de sociala, kulturella och ekonomiska orsakerna till shoppingens decentralisering och dess effekter på stadslivet. Få studier har dock hittills fokuserat på den föränDuring recent decades, shopping’s geographical manifestations have altered radically and the presumed ‘death’ of town centre retailing has become a public concern. The social, cultural, and economic backgrounds of this decentralisation of retail and its effects on city life have been studied comprehensively. However, to date, few studies have examined the changing dynamics of non-mainstream shoppi

Exposure to endocrine disrupting chemicals (EDCs) may impact early growth, although information is limited on exposure to combination of multiple EDCs. We aimed to evaluate the effect of prenatal exposure to EDC mixtures on birthweight z-scores and childhood weight trajectories. Twenty-six proven and suspected EDCs, were analyzed in prenatal urine and blood samples from 1118 mothers participating

Background and aims: Skin autofluorescence (AF), a measure of tissue accumulation of advanced glycation endproducts (AGEs), has been associated with diabetes and cardiovascular disease. However, the association of skinAF with subclinical coronary atherosclerosis in the general population is largely unknown. Our study aimed toexamine the associations between skin AF and subclinical atherosclerosis

Quantiferon-TB Gold Plus (QFT-Plus) is an interferon gamma release assay used to diagnose latent tuberculosis (LTB). A borderline range (0.20 to 0.99 IU/ml) around the cutoff (0.35 IU/ml) has been suggested for the earlier QFT version. Our aims were to evaluate the borderline range for QFT-Plus and the contribution of the new TB2 antigen tube. QFT-Plus results were collected from clinical laborato

BACKGROUND: Available evidence suggests that mitochondrial DNA copy number (mtDNA-CN) may differ among patients with mental disorders compared to the general population. However, whether mtDNA-CN is independently associated with the subsequent incidence of mental disorders remains unclear.MATERIAL AND METHODS: We used droplet digital PCR to measure the absolute mtDNA-CN in DNA samples obtained fro

This study aims to explore how physicians make sense of and give meaning to their decision-making during obstetric emergencies. Childbirth is considered safe in the wealthiest parts of the world. However, variations in both intervention rates and delivery outcomes have been found between countries and between maternity units of the same country. Interventions can prevent neonatal and maternal morb

Introduction There is controversy regarding the importance of air-transmitted infections for surgical site infections (SSIs) after orthopaedic surgery. Research has been hindered by both the inability in blinding the exposure, and by the need for recruiting large enough cohorts. The aim of this study is to investigate whether using a new form of air purifier using plasma air purification (PAP) in

Background and Purpose - Data regarding the association between blood pressure level and incidence of stroke subtype, especially primary intracerebral hemorrhage (PICH) subtypes, is sparse. This population- based study explored the relationship between blood pressure and the incidence of cerebral infarction, and PICH, with lobar and nonlobar location. Methods - Risk factors were assessed in 27 702

Introduction: Patients with pancreatic ductal adenocarcinoma (PDAC) have a dismal prognosis. The majority of patients are diagnosed at an advanced stage, and for these patients, the only possible treatment is palliative chemotherapy. There are increasing data from retrospective studies indicating that a subgroup of patients with liver-limited metastases may benefit from surgical treatment of liver

BACKGROUND: Few population studies have assessed the prevalence of various psychiatric disorders separately for sexual and gender minority groups, and none in an adolescent population. Given the increased mental health problems in sexual and gender minority groups combined, the present study aimed to estimate prevalence of mental disorders in separate sexual minority groups as well as gender disco

OBJECTIVES: Penicillin V (PcV) is considered the first-line treatment for community-acquired pneumonia in Scandinavian countries, although data supporting this recommendation are scarce. Thus, this study aimed to compare PcV and amoxicillin regarding the risk of treatment failures in children aged >5 years and adults treated for pneumonia in primary care.METHODS: In this retrospective study of hea

Att placeras på HVB är en av de mest ingripande insatserna inom socialt arbete. För ungdomar innebär den ofta att tillvaron blir präglad av förändring och en känsla av att framtiden är osäker. Licentiatuppsatsen fördjupar kunskapen kring existentiella utmaningar som kan uppstå i denna process. Studien har en teoretisk utgångspunkt i existentiell filosofi och fokuserar på hur grundläggande livsvillWhen young people are placed in residential care (HVB) it is one of the mostfar-reaching interventions in social work, often involving significantdisruptions to their everyday lives, future outlook, and sense of self. Whilesuch placements frequently raise questions about meaning and freedom thesechallenges remain largely unexplored from an existential perspective in bothresearch and practice. This

BACKGROUND: Catheterization of the vein is frequently a painful procedure. Assessing venous cannulation induced pain (VCP) before surgery have been used to predict the intensity of postoperative pain and postoperative opioid consumption. The aim of this study was to investigate the intra-individual variation in venous cannulation induced pain at three consecutive time points and factors influencin

Stored-product moths cause large economic damage in food-processing industries and storage facilities. Control of indoor pests is currently dealt with locally, and control strategies seldom include different mills or cooperative industries in joint efforts to reduce infestations. In colder climates where conditions hinder flight dispersal of stored-product moths, we hypothesize that human transpor