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Background and purpose: Severe acute pancreatitis (SAP) is characterized by trypsinogen activation, infiltration of leucocytes and tissue necrosis but the intracellular signalling mechanisms regulating organ injury in the pancreas remain elusive. Rho-kinase is a potent regulator of specific cellular processes effecting several pro-inflammatory activities. Herein, we examined the role of Rho-kinase

Objectives. Human leucocyte antigens (HLAs) are polymorphic molecules involved in antigen presentation. Associations between HLA type and autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis, are well established but the potential association of genetic variation affecting antigen presentation with cardiovascular disease has not been systematically investigated in large cohorts. T

Aims: Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where mus

Context: Effect of GH therapy in short non GH deficient children, especially idiopathic short stature (ISS) has not been clearly established owing to lack of controlled trials until final height (FH). Objective: To investigate the effect of two GH doses compared with untreated controls on growth to FH in short children mainly with ISS. Design and Setting: A randomized, controlled, long-term multic

Osteoporosis is a common complex disorder in postmenopausal women leading to changes in the micro-architecture of bone and increased risk of fracture. Members of the low-density lipoprotein receptor-related protein (LRP) gene family regulates the development and physiology of bone through the Wnt/β-catenin (Wnt) pathway that in turn cross-talks with the bone morphogenetic protein (BMP) pathway. In

Two hundred year's ago, Höganä's, a town situated in the north-west part of the county of Skåne, about 20 km north of the city of Helsingborg, had no local pottery tradition's. Höganä's wa's then a tiny fishing village that even lacked a harbour. Coal had now and then been quarried from an opencast mine and the local inhabitant's had collected it from the beach at low tide for their personal need'

The sensation of dryness and irritation is essential in the sick building syndrome (SBS), and such symptoms are common in both office and hospital employees. In Scandinavia, the indoor relative humidity in well ventilated buildings is usually in the range 10-35% in winter. The aim of this study was to evaluate the effect of steam air humidification on SBS and perceived air quality during the heati

Questions around school choice have attracted growing attention among educational scholars worldwide, and there is by now a burgeoning body of literature that links school choice to (i) the marketization and commercialization in education, (ii) new modes of governance in education, and (iii) individualized patterns of life-planning among families who see themselves increasingly exposed to global c

OBJECTIVE: Genome-wide association studies have begun to elucidate the genetic architecture of type 2 diabetes. We examined whether single nucleotide polymorphisms (SNPs) identified through targeted complementary approaches affect diabetes incidence in the at-risk population of the Diabetes Prevention Program (DPP) and whether they influence a response to preventive interventions. RESEARCH DESIGN

Electricity and gas prices are characterized by sharp increases or decreases in their price, followed a few days later by an equally large decreases or increases. These phenomena are called spikes or drops and are causing headaches for system developers and planners. One of the explanations for the spikes are sudden increases in demand (eg cold weather) and/or decreases in supply (eg emergency shu

Brottsligheten inom den kriminella miljön utförs idag oftare i offentliga miljöer. Den allvarliga brottsutvecklingen i Sverige har föranlett ett stort behov av brottspreventiva åtgärder. En åtgärd som vidtagits är lag (2024:7) om preventiva vistelseförbud som syftar till att förebygga brott med anknytning till kriminella nätverk och öka tryggheten på allmänna platser. Ett preventivt vistelseförb

Emotionsreglering (ER) innebär en förmåga att moderera varaktigheten och intensiteten av negativa känslomässiga upplevelser. Den aktuella studien utökar tidigare kunskap om ER i tonåren genom att anta en personcentrerad ansats för att undersöka profiler karaktäriserade av olika användning av följande ER-strategier: ruminering, socialt stöd, positiv omorientering, distraktion, kreativitet och aggreEmotion regulation (ER) refers to the ability to moderate duration and intensity of negative emotional experiences. The current study extends existing knowledge of ER in adolescence by adopting a person-centered approach to examine ER profiles characterized by different uses of the following ER strategies: rumination, social support, positive reorientation, distraction, creativity and aggression,

Uppsatsen syftar till att beskriva och analysera hur minoritetsaktier värderas i marknadsnoterade och ej marknadsnoterade bolag, i händelse av att ett tvångsinlösenförfarande påkallats enligt svensk aktiebolagsrätt. Uppsatsen redogör för lagstiftarens syfte med reglerna om tvångsinlösen, hur reglerna historiskt vuxit fram och hur rättsläget sett ut innan, och ser ut under, 2005 års aktiebolagslag.