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Background and aims: Heart transplantation is the preferred treatment for selected patients with end stage heart failure. Kidney function often declines after heart transplantation. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) slow the decline in eGFR in different populations. However, the effect of SGLT2i on kidney function in heart transplant recipients is unknown. Methods: The Dapaglifloz
Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was
Introduction: Alcohol use has significant health implications, yet the association between alcohol use and respiratory symptoms remains relatively understudied. This study examines the prevalence of hazardous alcohol use and its associations with breathlessness, chronic cough, and health-related quality of life (HRQoL) and whether these associations with chronic airway limitation (CAL) differ by a
BACKGROUND: Selective glomerular hypofiltration syndrome (SGHS), formerly shrunken pore syndrome, an emerging marker of glomerular dysfunction, is associated with worsened prognosis in cardiovascular disease, but its role in kidney failure remains underexplored. Osteopontin (OPN) is associated with worsening kidney function and prognosis in chronic kidney disease.PURPOSE: To explore if increased l
Purpose: The study aimed to investigate the associations between impaired spirometry such as obstructive pattern and preserved ratio impaired spirometry (PRISm) and occurrent cardiovascular events and deaths in patients with acute myocardial infarction. Patients and Methods: Cohort study of 517 patients with age ≥40 years and ≥10 pack-years of smoking, hospitalized for myocardial infarction at eig
Background: Polygenic risk scores (PRSs) strongly discriminate for prostate cancer risk at the population level. The role of these genetic scores in determining prostate cancer survival is unclear, potentially due to methodological issues. Methods: We included 19,607 men from the Malmö Diet and Cancer Study (MDCS) and the Health Professionals Follow-up Study (HPFS) and analyzed 20-year incidence a
Russia’s full-scale invasion of Ukraine in February 2022 produced one of the largest displacement movements in contemporary Europe, with millions of Ukrainians seeking protection across the European Union. While migration from Ukraine has often been understood through the lenses of safety, protection, and humanitarian need, wartime mobility can also become morally charged. Decisions to leave, stay
Pappers- och massatillverkning har sedan början av 1900-talet varit en ekonomiskt viktig industri för Sverige men har historiskt bidragit till stora föroreningsutsläpp, något som man försökt åtgärda genom såväl svensk lagstiftning som på EU-nivå. I denna uppsats har fokus lagts på två huvudsakliga typer av utsläpp, dessa är brunt vatten och fibrer. Brunt vatten orsakas av högt innehåll av chromoph
Thesis aim: This study examines how consumers of second-hand fashion navigate and sustain the tension between sustainability ideals and continued consumption, and what this reveals about how ideology operates in circular fashion markets. Theoretical Perspective: The study is grounded in critical Consumer Culture Theory and critical marketing, using Žižekian psychoanalytic ideology as the primary
BACKGROUND: The EAT-Lancet Commission introduced the planetary health diet to promote human health while reducing environmental impact. However, no study has yet examined how adherence to this diet is associated with risk of irritable bowel syndrome (IBS).OBJECTIVE: This study aimed to investigate the association between the planetary health diet index (PHDI) and the risk of developing IBS.METHODS
Co-creation is gaining popularity as a form of public participation, especially in urban environments, as a way to engage the public and private sectors more fully for increased solutions to complex challenges like climate change. However, co-creation can be expensive and take time and resources to implement. By conducting a literature review and interviewing co-creation participants from three Eu
PURPOSE – Patients with breast cancer in Ethiopia are generally diagnosed with late-stage disease, and there is a high proportion of young female and male patients. The role of genetic predisposition is yet unknown in this setting. To increase the knowledge about hereditary breast cancer in Ethiopia, this study investigated germline pathogenic variants (PVs) in breast cancer–predisposing genes in
Background: The prognostic significance of myocardial infarction with non-obstructive coronary arteries (MINOCA) in older adults remains uncertain, particularly in comparison with revascularized acute coronary syndromes (ACS) and other acute myocardial injury phenotypes. Methods: In the prospective population-based cohort of the Malmö Diet and Cancer Study (n = 30,466), 925 participants who exp
Aim: We aimed to investigate the prevalence of self-reported kinesiophobia seven months after out-of-hospital cardiac arrest (OHCA) and its relationship with self-reported and objectively assessed physical activity. Additionally, to explore the relationship between self-reported kinesiophobia and symptoms of anxiety and depression.Method: Cross-sectional sub-study conducted within the Targeted HypAim: We aimed to investigate the prevalence of self-reported kinesiophobia seven months after out-of-hospital cardiac arrest (OHCA) and its relationship with self-reported and objectively assessed physical activity. Additionally, to explore the relationship between self-reported kinesiophobia and symptoms of anxiety and depression.Method: Cross-sectional sub-study conducted within the Targeted Hyp
Background: – When decision makers use evidence from a randomized trial to inform population-level decisions, the target population they envision rarely aligns with the population of individuals who enrolled in the trial. Here, we extend inferences from the VALIDATE-SWEDEHEART randomized trial (hereafter, the index trial), which compared the effects of bivalirudin and heparin during percutaneous c
Det övergripande syftet med denna uppsats är att klargöra begreppet den demokratiska rättsstaten och de principer som upprätthåller den, samt att identifiera och analysera de samtida hot och utmaningar som den demokratiska rättsstaten står inför. I en osäker och turbulent omvärld, där geopolitiska maktbalanser skiftar, är forskning om rättsstatens innebörd och skyddsmekanismer av stor betydelse. FThe main aim of this essay is to clarify the concept of the democratic rule of law and the principles that uphold it, as well as to identify and analyze the contemporary threats and challenges it faces. In an uncertain world of shifting geopolitical balances of power, research on the meaning of the rule of law and its protective mechanisms is of significant importance. To fulfil this purpose, the
