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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), force

Selenoprotein P deficiency is associated with higher risk of incident heart failure

AbstractIntroductionSelenium deficiency has been associated with mortality, cardiovascular disease and worsened prognosis in heart failure (HF). In a recent population-based study, high selenium levels were shown to be associated with reduced mortality and reduced incidence of HF, but only in non-smokers. Here, we aimed to examine if selenoprotein P (SELENOP), a main selenium carrier protein, is a

Neurotensin Gene rs2234762 C>G Variant Associates with Reduced Circulating Pro-NT Levels and Predicts Lower Insulin Resistance in Overweight/Obese Children

Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. The circulating levels of its precursor, pro-NT, predicts the presence and development of metabolic and cardiovascular dise

The governmentalisation of risk in liberal democracies : Four processes both making and breaking the governing of risk on the societal level

Numerous risks threaten modern society. Some are new, while others have existed since the beginning of time, but none have been governed on a societal level since their inception. Despite the abundance of literature addressing the governance of various risks, the processes by which they become governable in the first place have gotten little attention. As a result, this paper aims to improve our k

Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder : A pilot randomised controlled trial with long-term follow-up

Objective Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format. Design A pilot, single-blind, parallel

Between Law and Safety : Licensed Aircraft Maintenance Engineers and the Socio-professional Construction of Legality in European Civil Aviation

Den undersökning och intervjubaserade mixed metods-forskningen som presenteras i denna sammanläggningsavhandling utforskar hur flygtekniker i Sverige, Norge och Portugal upplever att arbeta under den vertikala kedjan av hård och mjuk lagstiftning som utgör Europeiska Unionens reglering av denna sektor. Genom att fokusera på händelserapportering och certifiering av att flygplan kan tas i drift, som

Bacteraemia and infective endocarditis with Streptococcus bovis-Streptococcus equinus-complex: a retrospective cohort study

BACKGROUND: Streptococcus bovis/equinus complex (SBSEC) comprise several species and subspecies and is a common cause of infective endocarditis (IE). S. gallolyticus subsp. gallolyticus (Sg gallolyticus) accounts for a majority of SBSEC IE, but the risk of IE for other subspecies is largely unknown. We aimed to investigate the clinical presentation of bacteraemia, and proportion of patients with I

Birthweight, BMI in adulthood and latent autoimmune diabetes in adults : a Mendelian randomisation study

Aims/hypothesis: Observational studies have found an increased risk of latent autoimmune diabetes in adults (LADA) associated with low birthweight and adult overweight/obese status. We aimed to investigate whether these associations are causal, using a two-sample Mendelian randomisation (MR) design. In addition, we compared results for LADA and type 2 diabetes. Methods: We identified 43 SNPs actin

Collaborative housing as a socio-spatial system from a critical realism perspective. Can unintended consequences be understood as causal mechanisms?

Holism, abduction and causality are ways of reasoning that can complement each other to enable better understanding of contemporary wicked problems. Current social challenges include a global housing crisis, unwanted isolation and polarized societies. Systems thinking is instrumental to zoom out a specific phenomenon in an attempt to capture the complexity of reality. It also provides a holistic v

Malmö POTS symptom score : Assessing symptom burden in postural orthostatic tachycardia syndrome

BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate (HR) increase on standing and symptoms of orthostatic intolerance, posing significant limitations on functional capacity. No objective tool exists to classify symptom burden in POTS.METHODS: We conducted a case-control study in 62 POTS patients and 50 hea

Proteomic Profiles of Body Mass Index and Waist-to-Hip Ratio and Their Role in Incidence of Diabetes

Context: It is unclear to what extent the plasma proteome of abdominal fat distribution differs from that of body mass index, and whether the differences have clinical implications. Objective: To evaluate the difference between the plasma proteomic profiles of body mass index (BMI) and waist-to-hip ratio (WHR), and then examine the identified BMI- or WHR-specific proteins in relation to incidence

Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization

Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD

Noninvasive Assessment of Left Ventricular Pressure-Volume Relations : Inter- and Intraobserver Variability and Assessment Across Heart Failure Subtypes

A novel method to derive pressure-volume (PV) loops noninvasively from cardiac magnetic resonance images has recently been developed. The aim of this study was to evaluate inter- and intraobserver variability of hemodynamic parameters obtained from noninvasive PV loops in healthy controls, subclinical diastolic dysfunction (SDD), and patients with heart failure with preserved ejection fraction, mi

Protocolised reduction of non-resuscitation fluids versus usual care in patients with septic shock (REDUSE) : a protocol for a multicentre feasibility trial

INTRODUCTION: Administration of large volumes of fluids is associated with poor outcome in septic shock. Recent data suggest that non-resuscitation fluids are the major source of fluids in the intensive care unit (ICU) patients suffering from septic shock. The present trial is designed to test the hypothesis that a protocol targeting this source of fluids can reduce fluid administration compared w

Antibiotic prophylaxis and its effect on postprocedural adverse events in endoscopic retrograde cholangiopancreatography for primary sclerosing cholangitis

BACKGROUND AND AIM: Primary sclerosing cholangitis (PSC) is characterized by multiple strictures of the biliary tree. Patients with PSC frequently require repeated endoscopic retrograde cholangiopancreatography (ERCP) procedures. These procedures are encumbered by an increased incidence of infectious adverse events such as cholangitis. Evidence regarding whether antibiotic prophylaxis (AP) should

Virtual Tourism Staycation Revive (VTSr) to convey the Intangible through Augmented Reality

The increase in extreme weather confirms that in order to slow down climate change, unnecessary travel must be reduced. Consequently, tourism industry has an obligation to start launching more environmentally friendly travel concepts and replace destructive charter tourism until sufficient emission-free vehicles that run on electricity become norm. Developing Staycation into innovative and attract

Recruitment strategies and reach of a digital fall-prevention intervention for community-dwelling older adults

BACKGROUND: To have an impact on the population's health, preventive interventions have to reach a large proportion of the intended population. Digital solutions show potential for providing wider access to fall preventive exercise. However, there is a lack of knowledge about how to reach the target group. The aim of this study was to describe the recruitment process used in the Safe Step randomis