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Background: Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding metformin transporters has not been fully elucidated. We examined the DNA methylation of these genes in the li

Objectives: Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. Material and methods: Blood samples were collected prior to lung ca

Although it is generally anticipated that innovation as such leads to regional prosperity (Asheim et al. 2011) there is lack of empirical evidence that confirms the direct linkage between the innovation capabilities of regions and welfare increase. It is suggested that entrepreneurship can be seen as a missing link that helps to transfer innovations into business outcomes (Braun et al. 2012). The

Existing installations and energy systems in most commercial buildings could be used in a more efficient way to provide savings – both in terms of energy and load demand. The key for effective operation is a thorough and detailed analysis of energy use patterns that creates essential baseline for energy savings and the development of demand response (DR) strategies. The knowledge of energy deman

1.Among small animals dispersal parameters are mainly obtained by traditional methods using population studies of marked individuals. Dispersal studies may underestimate the rate and distance of dispersal, and be biased because of aggregated habitat patches and a small study area. The probability of observing long distance dispersal events decreases with distance travelled by the organisms. In thi

The radiation balance of urbanised catchments differs from their rural counterparts, with snowpacks experiencing either enhanced or decreased irradiance depending on snowpack location and condition. As snowmelt is largely driven by radiation inputs, changes to localised irradiance (and melt rates) have implications for urban runoff generation. Storm- and wastewater drainage systems in cold regions

Distributed Decision Making and Control is a mathematical treatment of relevant problems in distributed control, decision and multi-agent systems, The research reported was prompted by the recent rapid development in large-scale networked and embedded systems and communications. One of the main reasons for the growing complexity in such systems is the dynamics introduced by computation and communi

Popular Abstract in English The long-term stability of the global terrestrial carbon sink has been a matter of concern in that a weakening would have serious consequences for atmospheric CO2 concentrations and, hence, for further changes in climate. High northern latitudes are of special importance for the global carbon budget as they store large amounts of organic matter in the soil and are expecHigh northern latitudes are of special importance for the global carbon budget as they store large amounts of organic matter in the soil and are expected to be the most strongly affected by climate change. Here we investigate carbon exchange in the subarctic mountain birch forest growing on the limit where tree growth is possible. The study sites are located close to the Abisko village in norther

The aim of this study is to generate a quality-controlled sub-kilometer dataset of the fraction of absorbed photosynthetically active radiation (FAPAR) across Scandinavia from satellite. FAPAR is required for estimating the amount of PAR absorbed (APAR) by vegetation, which in turn allows for estimation of carbon uptake. In this study, FA-PAR was modeled from normalized difference vegetation index

The injury risk for bus passengers is low compared to car users. However, bus passengers also run the risk of sustaining injuries as vulnerable road users: as pedestrians or cyclists to and from the bus stop. Among vulnerable road users, seniors are a particularly important group. Hitherto, injury data have mainly been based on police-reported accidents. These accidents reveal bus occupant safety,

Scania, the dangerous peninsula. History, identity and ideology 1865 to 2000 This dissertation deals with the organized written history of Scania 1865 to 2000 and the intersection of history, identity and ideology. Under what circumstances were the history produced and circulated? What was its significance for identity and ideology alike? The theoretical and analytical inspiration is drawn from P

This report discusses the role of the program coordinator in a faculty where the organisation of connected and integrated courses in bachelor programmes is a fairly new phenomenon. In the Faculties of Humanities and Theology at Lund University there has been a strong tradition to design an individual bachelor exam by combining independent courses. During the last ten years an increasing number of

Introduction: Heterogeneity in cognitive outcomes and response to treatment has been described in Alzheimer’s disease (AD). Using the method of mixed models, higher resolution can be obtained to identify potential predictors of long-term outcomes. Aims: To analyse the impact of the APOE genotype, non-steroidal anti-inflammatory drug (NSAID) therapy and cholinesterase inhibitor treatment (ChEI) on

Whistle-blowing can serve as a powerful mechanism helping policy-makers and other stakeholders recognize ethical misconduct and other types of wrongdoing in autonomous public agencies. This mechanism is of particular importance in major public sector reforms, such as agency mergers, when it may be difficult to secure continuity in the quality of organizational processes. Yet, we know little of wha

As the saying goes, “a beloved child has many names”. So, too, is the case with the concept to be dealt with in this paper. Over the years various concepts have been used to denote education in a lifetime perspective, such as “education permanente”, recurrent education and lifelong learning. There are many who have disputed the correctness or appropriateness of one or the other concepts. Boudard (

Background: The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemod