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Update on intra-arterial thrombolysis in patients with lower limb ischemia.

Intra--arterial thrombolysis has become the most important minimal--invasive treatment option to treat acute lower limb ischemia. Although hemorrhagic stroke is a dreaded complication, it is considered beneficial to many fragile and elderly patients where vascular surgery is not an option. This review outlines current results after intra--arterial thrombolysis with low dose recombinant tissue plas

Uptake of atrial fibrillation screening aiming at stroke prevention: geo-mapping of target population and non-participation

Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants' profile. We intended to geo-map the target population and non-participation in an attempt to understand factors related to screening uptake and, thereby

Aspects of skin cancer diagnosis in clinical practice

Skin cancer incidence is increasing in fair-skinned populations. The three most common skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). A correct diagnosis is crucial for an efficient and tailored treatment for the skin cancer patient. The purpose of this thesis was to evaluate different aspects of the preoperative diagnosis of skin cancer. Th

Variations in Quality Indicators of Acute Stroke Care in 6 European Countries: The European Implementation Score (EIS) Collaboration.

BACKGROUND AND PURPOSE: Quality indicators serve as standards of care by which performance of individual hospitals is measured. Although several audits for monitoring quality of stroke care have been established in Europe, there is currently no consensus on quality indicators for acute stroke care or for methodology for collecting information on these measures. METHODS: An up-to-date inventory on

Ytterholmen revisited - implications for the Late Wenlock stratigraphy of Gotland and coeval extinctions

The latest Cyrtograptus lundgreni graptolite Chron (Late Wenlock, middle Silurian) is characterized globally by the Mulde Event faunal extinctions and glacio-eustatic sea-level change. Only in the last decade has it been recognized as one of the most severe extinction events of the Silurian Period. A section spanning the Slite Group-Halla Formation boundary on the islet Ytterholmen off main Gotlan

Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives

Background & Aims: Iron overload may be carcinogenic. Patients with hereditary hemochromatosis (HH) are reportedly at a 20-200-fold risk of intrahepatic cancer, but the reported risks for nonhepatobiliary cancers are conflicting. The risk of cancer in heterozygous individuals (estimated allele frequency, 1/10 to 1/20) is unknown. This study aimed to better assess these risks. Methods: We perfo

Does a long-term oscillation in nitrogen concentration reflect climate impact on submerged vegetation and vulnerability to state shifts in a shallow lake?

Various ecosystems, including shallow lakes, are suggested to possess alternative stable state dynamics. The response of such systems to environmental change is non-linear and not fully reversible, which calls for identification of feedback mechanisms and subtle changes connected to structural stability. Here, we used a 25-year data series on water chemistry to make inferences on processes prior t

Association of TNFSF15 polymorphism with irritable bowel syndrome

Background Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide. Although a genetic component is suspected, unambiguous susceptibility genes have so far not been identified. This study tested the hypothesis that genes contributing to epithelial barrier integrity, control of mucosal immune responses and interactions

Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations

BACKGROUND: Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES: This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to evaluate their suitability for assessing perina

The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

The myeloid translocation gene 16 product MTG16 is found in multiple transcription factor-containing complexes as a regulator of gene expression implicated in development and tumorigenesis. A stable Tet-On system for doxycycline-dependent expression of MTG16 was established in B-lymphoblastoid Raji cells to unravel its molecular functions in transformed cells. A noticeable finding was that express

Enantiomeric Specificity in a Pheromone-Kairomone System of Two Threatened Saproxylic Beetles, Osmoderma eremita and Elater ferrugineus

The scarab beetle Osmoderma eremita and its larval predator, the click beetle Elater ferrugineus, are threatened saproxylic beetles regarded as indicators of the species-richness of insect fauna of hollow deciduous trees. Male O. eremita produce the pheromone (R)-(+)-gamma-decalactone to attract conspecific females, and this compound is also utilized by E. ferrugineus as a kairomone, presumably fo

Field Abundance Patterns and Odor-Mediated Host Choice by Clover Seed Weevils, Apion fulvipes and Apion trifolii (Coleoptera: Apionidae)

The clover seed weevils Apion fulvipes Geoffroy, 1785 and Apion trifolii L., 1768 (Coleoptera: Apionidae) cause major losses to seed production of white clover (Trifolium repens L.) and red clover (Trifolium pratense L.), respectively. Clover is important as animal forage and an alternative to inorganic fertilizers. Because clover is mainly pollinated by bees, the use of insecticides in management