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Feasibility study of the internet-based intervention “Strategies for Empowering activities in Everyday life” (SEE 2.0) for use by people with chronic diseases and long-term disorders in healthcare: A study protocol.

Introduction: Proactive and easily accessible interventions are needed to support people with long-term health conditions who experience limitations in activities of everyday life. However, there is a lack of interventions that promote self-management skills that prevent deterioration and improve health. The internet-based programme 'Strategies for Empowering Activities in Everyday Life' (SEE) sup

Performance of individual audit filters in predicting opportunities for improvement in adult trauma patients

Background Trauma audit filters, based on standards of care, serve as quality indicators and screening tools for patient cases to be assessed at interdisciplinary morbidity and mortality conferences. These conferences aim to identify potential opportunities for improvement in the care of trauma patients. This study aimed to determine the performance of individual audit filters in predicting opport

Central Zika virus infection causes hypothalamic inflammation and persistent insulin resistance in adult mice

Zika virus (ZIKV) is a neurotropic flavivirus capable of infecting the adult brain, however its impact on hypothalamic function and metabolic regulation remains unclear. Here, we show that ZIKV invades the hypothalamus of immunocompetent adult mice, where it replicates and persists, leading to sustained insulin resistance. Following infection, ZIKV RNA and negative strand were detected in the hypo

Registerkvalitet och dess inverkan vid värdering av jordbruksmark

Syftet med detta examensarbete var att klargöra vilka statistikkällor innehållande arealuppgifter för jordbruksmark som finns åtkomliga samt att undersöka skillnaderna mellan de olika källorna. Intentionen var även att komma fram till förslag kring hur inhämtningen av taxeringsuppgifter vid fastighetstaxeringen kan förenklas respektive underlättas för fastighetsägare samt hur andra statistikkällor

Metabolic perturbations and ectopic fat deposition in men with low birth weight : Effects of a 4-week carbohydrate overfeeding challenge

Low birth weight (LBW) is a risk factor for type 2 diabetes (T2D). We hypothesized that 4 weeks of carbohydrate overfeeding (COF) with +25% energy would unmask key T2D perturbations among 22 nonobese LBW men, including five with screen-detected metabolic dysfunction-associated steatotic liver disease (MASLD), compared with 21 healthy control participants with normal birth weight (NBW). Body weight

Early Postreperfusion Proteomics Reveal Divergent Inflammatory Responses in Kidney Transplantation with Implications on Outcomes

BACKGROUND: Ischemia/reperfusion injury is an unavoidable consequence of kidney transplantation, yet the characteristics of the immediate immune response after reperfusion and its impact on transplant outcomes remain poorly characterized in the clinical setting.METHODS: We conducted a cohort study including 63 kidney transplant recipients (26 living-donor, 37 deceased-donor) with an extended 4-y f

Venous thromboembolism in live kidney donors--a prospective study

AIM: The aim of this study was to evaluate risk factors for venous thromboembolism (VTE) and deep vein thrombosis after living donor nephrectomy in a center using extensive preoperative screening and perioperative venous duplex scan.MATERIAL AND METHODS: Thrombophilia screening and pre- and postoperative ultrasonographies were performed in 130 consecutive living kidney donors (laparoscopic 105, op

Professionellas perspektiv på psykisk ohälsa: attributionsskillnader mellan läkare, psykologer och kuratorer kopplat till stigma mot psykiatriska diagnoser

Vårdgivares förståelse av psykiatriska tillstånd har föreslagits hänga samman med deras stigma gentemot personer med sådana tillstånd. Detta stigma kan yttra sig genom förminskande beteenden, uteslutning från beslutsprocesser och försämrade terapeutiska relationer. Denna uppsats undersöker huruvida det finns en relation mellan psykiatrisk profession, attributionella ramverk och stigma gentemot perMental health professionals’ understanding of psychiatric conditions has been proposed to relate to their stigma toward individuals with such diagnoses. Such stigma may manifest through dismissive behavior, exclusion from decision-making and weakened therapeutic relationships. This thesis investigates whether psychiatric profession, attributional frameworks, and stigma toward ADHD, anxiety disorde

Microbial associations and viruses on the risk of celiac disease (MAVRiC) : a longitudinal post-hoc case-cohort study

Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-

On demand-responsive transport configurations, traveller interaction and preferences : a survey from the perspective of older people

Over the years, demand-responsive transport (DRT) and similar concepts have been implemented and tested in different environments and in different configurations. However, many of these transport services have been abandoned, for various reasons. Previous research shows that some of the most important success factors for a DRT service to sustain over the years are low-cost solutions adjusted to a

It can spill out on to the street : Revitalization potential of an adaptive reuse project

The revitalization of existing neighborhoods has been a frequent topic of public and academic debate in post–industrial times. Yet, little is known about the potential of individual, commercial real estate development projects to revitalize neighborhoods. Adaptive reuse of existing buildings, especially when combined with collaborative spaces, have been linked to positive social impacts beyond cul

Psykologstudenters inställning till exponering som behandlingsmetod och syn på att integrera exponering inom psykodynamisk terapi

Exponering är en av de mest empiriskt validerade behandlingsmetoderna inom kognitiv beteendeterapi (KBT) och har visat sig vara effektiv vid flera ångestrelaterade tillstånd. Trots detta visar forskning att metoden ofta möter motstånd bland terapeuter, vilket kan bidra till en underanvändning i praktiken. Det är oklart i vilken utsträckning ett sådant motstånd finns bland psykologstudenter. SyftetExposure is one of the most empirically validated treatment methods within cognitive behavioural therapy (CBT) and is effective in treating several types of anxiety. Despite this, research shows that the method often faces resistance among therapists, contributing to underutilization in clinical practice. It is unclear to what extent this resistance exists among psychology students. This explorati

Real-world Cost per Responder Among Different Classes of Biologics for the Treatment of Psoriasis

Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both