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Combinations of genetic and environmental factors contribute to the pathogenesis of type 2 diabetes (T2D); however, our knowledge of the molecular mechanisms by which these factors trigger diabetes is still limited. While genome-wide association studies have identified and characterized more than 60 genomic loci associated with T2D, recent methylome charts and reference regulatory maps obtained fr

Digital research data is often advanced as a trouble-free concept and used to describe the material of research at all stages in a research process. However frequently such framing lacks understanding of the roles of disciplinary and organisational cultures, and of what the various practices, including those of funding policy and university administration, involved in shaping what research data ar

Objectives: To examine whether the mix of community and institutional long-term care (ILTC) for people with dementia (PwD) in Europe could be improved; assess the economic consequences of providing alternative services for particular groups of ILTC entrants and explore the transnational application of the ‘Balance of Care’ (BoC) approach. Method: A BoC study was undertaken in Estonia, Finland, Fra

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 diabetes, may also be associated with altered DNA methylation in visceral and subcutaneous adipose tissue. Furthermore, linking epigenetic variation in target tissues to similar changes in blood cells may identify n

Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of

Background More than half of cardiovascular mortality occurs outside the hospital, mainly due to consistently low survival rates from out-of-hospital cardiac arrest. Methods This is a prospective, nested, case-control study derived from the Västerbotten Intervention Programme and the World Health Organization's Multinational Monitoring of Trends and Determinants in Cardiovascular Disease study in

Nonverbal behaviour has an important function in team sports, but research is limited. Adopting a psychological momentum (PM) framework, this study explores the relationship between a team’s history of events, nonverbal post-shot celebrations in the form of gestures and touch shown by the shooter after scoring, and subsequent team performance during handball matches. A naturalistic design with sys

Type 2 diabetic patients suffer from insulin resistance and reduced insulin secretion. Osteopontin (OPN), a versatile protein expressed in several tissues throughout the body including the islets of Langerhans, has previously been implicated in the development of insulin resistance. Here we have investigated the role of OPN in insulin secretion using an OPN knock out mouse model (OPN-/-). Ultra-st

Advanced analytical techniques have revealed a high degree of complexity in the chemical makeup of dissolved organic matter (DOM). This has opened the door for a deeper understanding of the role of DOM in the aquatic environment. However, the expense, analytical cost, and challenges related to interpretation of the large datasets generated by these methods limit their widespread application. Optic

Psychological stress has been reported as a possible trigger of atrial fibrillation (AF). No studies have investigated whether any association between stress and AF could be modified by genetic susceptibility to AF (AF-genetic risk score (AF-GRS)). 8765 men and 13,543 women from the Malmö Diet Cancer Study, a population-based cohort, were included in the analyses. A variable representing stress wa

Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capability of echovirus strains to infect human exocrine and endocrine pancreatic cells.

Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contain multiple predicted microRNA (miRNA)-binding sites, and binding of different miRNAs may independently or coordinately regulate the expression of any given mRNA.

Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiogr

An improved understanding of the response of forest ecosystems to elevated levels of CO2 in the atmosphere is crucial because atmospheric CO2 concentration continues to increase at an accelerating rate and forests are an important sink in the global carbon cycle. Several CO2-enrichment experiments have now been running for more than 10 years, with highly variable short-term results after the first

Urban Squares suggests a specific and fresh take on agorology – the study of urban squares. The approach is one of recording everyday life and focusing on different ways to describe and investigate the public life and space of urban squares. The book comprises four empirical case studies of squares focusing especially on the urban material culture and spatio-temporal changes of these squares. The