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Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with G

Heart failure is a leading cause of morbidity and mortality1,2. Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion3–8. Recombinant natriuretic peptide infusions were deve

Cell death plays a pivotal role in many physiological processes, such as cell homeostasis, embryonic development, immune defence and in the pathophysiology of numerous diseases, such as cancer, infections and degenerative diseases. However, the lack of a comprehensive and up-to-date resource on cell death regulators poses a significant challenge to researchers in the field. Existing databases are of

Background: The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We describe our real-life approach of variant reassessment over time and we assess whether inconclusive variants are decreasing in monogenic obesity. Methods: We tested for monogenic obesity (genes: LEPR, POMC, ADCY3, PCSK1, CARTPT, SIM1, MRAP2, LEP, NTRK2, BDNF, KSR2, MAGEL2, SH2B1, MC

Objective: To describe healthcare professionals’ perception of current early rehabilitation practices and their preconditions, focusing on functional and cognitive stimulation facilitated by nurses and other healthcare professionals in Scandinavian intensive care units (ICUs). Design: Cross-sectional electronic survey administered to healthcare professionals. The survey was developed in Danish, tr

Denna avhandling undersöker (åter)uppbyggnaden av civilt försvar i Europa efter Rysslands annektering av Krim 2014. Mer specifikt analyserar den befintliga uppfattningar om civilt försvar och hur dessa formas i ett flernivåsammanhang, med fokus på samspelet mellan nationella, regionala och internationella institutioner. Genom ett diskursivt institutionellt perspektiv betonar avhandlingen den dynamThis dissertation examines the (re)emergence of civil defence in Europe in the aftermath of Russia's annexation of Crimea in 2014. More specifically, it investigates the existing conceptions of civil defence and how these are shaped in a multi-level institutional context, focusing on the interplay between national, regional, and international levels. Through the lens of discursive institutionalism

Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and t

The circular economy (CE) transformative model depends on policy design and implementation in multiple socio-economic contexts. Temporal priorities based on security concerns can stimulate risk-averse circular policies that compromise achieving Sustainable Development Goal 12 for responsible consumption and production. However, the CE literature lacks empirical evidence on how these concerns affec

Brain function requires continuous energy supply. Thus, unraveling brain metabolic regulation is critical not only for our basic understanding of overall brain function, but also for the cellular basis of functional neuroimaging techniques. While it is known that brain energy metabolism is exquisitely compartmentalized between astrocytes and neurons, the metabolic and neuro-energetic basis of brai

This study explored serious mental illness (SMI) in young adult offenders imprisoned for violent or sexual crimes, estimating the effects of neurodevelopmental disorders and early-life risk factors on the development of SMI, and its prospective long-term adverse outcomes. An all-male cohort of 266 violent offenders, assessed during imprisonment when aged 18–25 years (M = 21.8, SD = 1.9), was follo

Intresset för doping har varit stort sedan början av 1900-talet då idrotten professionaliserades. Idag finns en omfattande idrottslig reglering av doping. I Sverige är doping även ett brott som omfattas av lagstiftning. Regleringen av doping har varit, och är fortfarande, föremål för omfattande debatt. Ett stadgande som väckt stor uppmärksamhet är de idrottsliga reglernas princip om strikt ansvar.

The aim with this bachelor thesis is to to create an understanding for how people who primary do not define themselves as men experience the community in digital networks that is separatist for them, as well as examine what significance separatism has for people's perceived sense of community. The informants’ experiences of being a part of digital feminist communities that are free from men, a

Under den Svekonorvegiska orogenesen omkristalliserade stora delar av sydvästra Sverige och bildade metamorfa migmatitiska gnejser. I Idefjordenterrängen, väster om Mylonitzonen, har migmatiterna inte daterats och då kunskapen om de metamorfa processerna i området brister kan migmatiterna ge en bättre bild av när metamorfosen skedde. En migmatitisk gnejs från Delsjöområdet i östra Göteborg har dat

Göta älv är Sveriges största vattendrag som sträcker sig från Vänern ner till Kungälv där bifurkationen delar den i Nordre älv och Göta älv (Göteborgsgrenen). Vattendraget är ett riksintresse och används bland annat för fiske, rekreation, som recipient och framförallt råvattentäkt för många kringliggande vattenverk som försörjer cirka 700 000 invånare. Kungälv kommun bygger och planerar inför ett

Since digital games entered the market they have been classified as a problematic medium, something that makes people aggressive and isolated from their surroundings. A stereotype of a white, adult male, playing alone and killing virtual people started to spread in the public. During the summer and early autumn of 2016, a new game entered the public sphere, which made people all over the world lea

Begreppet genre är centralt inom musikvärlden och inom musikundervisning. Således är detta ett begrepp vi behöver förhålla oss till. Syftet med studien är att ta reda på vilken funktion genre har i sångundervisningen och hur begreppet kan behandlas. Genre har en tydlig plats i styrdokumenten för sång och instrumentalundervisningen på det estetiska programmet. Därför är detta en intervjustudie med Genre as an object of learning in vocal education - a study of vocal teachers’ view of genre and its function Musical genre as a concept is common and central in music and music education. Therefore, music teachers have to define and act to genre as a concept. The aim with this essay is to figure out which function genre has in the singing education and how genre can be managed. Since genre is a c

Uppsatsen behandlar Ombudsmannen mot Etnisk Diskriminering och Diskrimineringsombudsmannens bedömningskriterier vid handläggning av diskrimineringsärenden som berör etnisk diskriminering. Ombudsmännens bedömningar jämförs med Arbetsdomstolens beslut i 17 rättsfall som berör etnisk diskriminering. Syftet är att analysera om det finns en skillnad mellan ombudsmännens bedömningar och Arbetsdomstolens