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Background: Survival rates following a diagnosis of cancer vary between countries. The International Cancer Benchmarking Partnership (ICBP), a collaboration between six countries with primary care led health services, was set up in 2009 to investigate the causes of these differences. Module 3 of this collaboration hypothesised that an association exists between the readiness of primary care physic

Fasting glucose and insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association of a low-frequency nonsynonymous SNV in GLP1R (A316T; rs10305492; MAF=1.4%) with lower FG (β=-0.09±0.01

In timber housing constructions, vibrations can be a nuisance for inhabitants. Notably, the vibrational response of wooden floor systems is an issue in need of being dealt with more adequately in the designing of such buildings. Studies addressing human response to vibrations are needed in order to be able to better estimate what level of vibrations in dwellings can be seen as acceptable. In the p

The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the regulation of intracellular concentrations of cyclic nucleotides and cyclic nucleotide-dependent signaling pathways. Two PDE3 subfamilies, PDE3A and PDE3B, have been described. PDE3A and PDE3B hydrolyze cAMP and cGMP with high affinity in a mutu

Objective. Development of ascites in patients with liver cirrhosis is an ominous sign with a poor outcome. A liver transplantation must be considered, and it then becomes important to know if there are any factors indicating a worsened prognosis. Material and methods. We used official registers for a follow-up study of at least 5 years considering the prognosis of 155 prospectively recruited in-pa

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility when maternally inherited. By use of quantitative PCR and pyrosequencing of human adult islet and fetal

The aim of this study is to review recent data on dietary fiber (DF) and the glycemic index (GI), with special focus on studies from the Nordic countries regarding cardiometabolic risk factors, type 2 diabetes, cardiovascular disease, cancer, and total mortality. In this study, recent guidelines and scientific background papers or updates on older reports on DF and GI published between 2000 and 20

Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance. Global PTP1B deletion improves diet-induced obesity and glucose homeostasis via enhanced leptin signaling in the brain and increased insulin signaling in liver and muscle. However, the role of PTP1B in adipocytes is unclea

Review https://doi.org/10.1038/s41586-018-0087-1 New approaches for brain repair—from rescue to reprogramming Roger A. Barker1*, Magdalena Götz2,3* & Malin Parmar4* The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a sp

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/barker_nature.pdf - 2026-06-21

Tidskriften åter i tryck TEMA: MÄNSKLIGA RÄTTIGHETER HBTQ i fokus Val i Nepal Indien och Pakistan fyller 70 år Tidskrift om Indien, Pakistan, Sri Lanka, Bangladesh, Afghanistan, Nepal, Bhutan och Maldiverna #1 2018 Sydasien.se 2 3Nr 1 2018 Nr 1 2018 Utgivare: Tidskriftsföreningen SYDASIEN Ansvarig utgivare: Johan Mikaelsson Redaktör: Johanna Sommansson Redaktionsråd: Andreas Johansson, SASNET Admi

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/sydasien_2_2017_korrutskrift_7.pdf - 2026-06-21

https://www.historiska.lu.se/media/utbildning/dokument/kursplaner/SASH01.pdf - 2026-06-21

BACKGROUND: Animal and in vitro studies have indicated that human male reproductive disorders can arise as a result of disrupted androgen receptor (AR) signalling by persistent organic pollutants (POPs). Our aim in the present study was to compare serum xenoandrogenic activity between study groups with different POP exposures and to evaluate correlations to the POP proxy markers 2,2',4,4',5,5-hexa

Background: Therapy directed at the central nervous system (CNS) is an essential part of the treatment for childhood acute lymphoblastic leukemia (ALL). The current evaluation of CNS involvement based on cytomorphological examination of the cerebrospinal fluid (CSF) alone is not as sensitive with low cell counts as flow cytometric immunophenotyping (FCI) of the CSF. However, the importance of low

Fatal intoxications with opioids are known to be associated with an increased lung weight, as well as with brain and pulmonary edema and urinary retention. However, there is evidence to suggest that fatal intoxications with non-opioid substances are also associated with increased lung weight; however, the latter aspect has not been comprehensively analyzed. To determine to what extent opioid and n

The upcycling trend has received renewed attention in the past few years due to growing concerns for the environment related to increased resource consumption and waste volumes. Indeed, cities across the world are supporting resource upcycling initiatives by establishing do-it-yourself (DIY) repair cafes and makerspaces as a means to transform societies towards sustainable develop-ment. However, t